Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses

Singh, H. B.; Srivastava, Manoj; Singh, Alka; Srivastava, A. K.

doi:10.1111/j.1398-9995.1995.tb02515.x

Cited by 75 publications

(36 citation statements)

References 4 publications

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“…192 Polygodial-treated yeast cells showed a fragmentation of the cell membrane, formation of many vesicles in the cytoplasma, and changes of mitochondia and nucleus membrane. 193 A database substructure search resulted in the retrieval of a series of anticandidal compounds having a 5-dimethylhex-5-en-2-oyl (2O-DMH) substructure (a-terpineol (70), linalool (66), alphabisabolol (103), nerolidol (95), galanolactone (117), and trans-8b(17)epoxy-12-labdene-15,16-dial (120)), 194 wherein the increase of activity (lowest reported anticandidal MIC: 400, 225, 100, 25, 12,5 mg/mL) is correlated (r ¼ 0.91) to increase of molecular volume (174,179,258,342, 350 cubic angstrom, calculated with 195 ). The 2O-DMH side chain without the oxygen atom is found in zymosterol, a late and fungi specific intermediate in ergosterol biosynthesis.…”

Section: E Vapor Phase Activity Testsmentioning

confidence: 94%

“…However, several authors have also found the opposite effect, and therefore it was concluded that there is no clear predictability for the degree of hydroxylation and toxicity to microorganism. 121,201 To overview the structural similarities among flavonoids (174)(175)(176)(177)(178)(179)(180)(181)(182)(183)(184)(185)(186)(187)(188)(189)(190)(191)(192)(193), several compounds with a molecular weight higher than 350 Da were respected in Figure 7. The substitution pattern of compounds (186-193) followed rules, which point to a common mode of action, see Figure 8.…”

Section: E Vapor Phase Activity Testsmentioning

confidence: 99%

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Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Pauli

2005

Medicinal Research Reviews

104

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The most active low molecular weight compounds from higher plants against Candida species are compiled from a database of antimicrobials (Amicbase) to find out new hints on their mechanism of action. The selected compounds possess strong inhibitory activities in vitro against Candida species either in the agar diffusion test, bioautography, agar dilution test, serial dilution test, or activity in the vapour phase. The test conditions are listed thoroughly and aspects of the different methods and recent developments in the testing of anticandidal drugs are discussed. The anticandidal spectra of drugs, antiseptics, and disinfectants licensed on the major markets are given for comparison of activities with compounds from natural sources. So far known mechanisms of action are described and some new structure-activity relationships are deduced from relationships between biological activities and chemical and physical parameters. Main specific targets of natural anticandidals are the ergosterol pathway, respiratory chain, and chitin biosynthesis.

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Section: E Vapor Phase Activity Testsmentioning

confidence: 94%

Section: E Vapor Phase Activity Testsmentioning

confidence: 99%

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Pauli

2005

Medicinal Research Reviews

104

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“…Anticandidal and antidermatophytic activities of the essential oils from various Cinnamomum species have been demonstrated (Mastura et al, 1999). Cinnamaldehyde, isolated from Cinnamomum zeylanicum, has been identified as the major active fungitoxic component of the cinnamon bark oil against various yeasts, especially Candida albicans, which are involved in respiratory tract mycoses (Singh et al, 1995). The essential oil from Cinnamomum also exhibited strong antibacterial properties and its major constituent cinnamaldehyde possessed the strongest antibacterial activity compared with the other components (Chang et al, 2001).…”

Section: Introductionmentioning

confidence: 98%

Potentiation of antifungal activity of amphotericin B by essential oil fromCinnamomum cassia

Giordani

Régli²,

Kaloustian

et al. 2006

Phytother. Res.

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The antifungal activity of the essential oil from Cinnamomum cassia, alone or combined with amphotericin B, a drug widely used for most indications despite side-effects was investigated. The composition of the oil was analysed by GC/MS and characterized by its very high content of cinnamaldehyde (92.2%). The minimal inhibitory concentration (MIC 80%), used to evaluate the antifungal activity against Candida albicans, was determined by a macrobroth dilution method followed by a modelling of fungal growth. The essential oil of Cinnamomum cassia exhibited strong antifungal effect (MIC 80% = 0.169 microL/mL and K(aff) = 18,544 microL/mL). A decrease of the MIC 80% of amphotericin B was obtained when the culture medium contained essential oil concentrations ranging from 0.08 to 0.1 microL/mL. The strongest decrease (70%) was obtained when the medium contained 0.1 microL/mL of essential oil. This potentiation of amphotericin B obtained in vitro may show promise for the development of less toxic and more effective therapies especially for the treatment of HIV infection.

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“…Nevertheless, the excessive addition may be harmful due to allyl sulfide concentrations, which interfere in metabolism, resulting in low growth (LEE; GAO, 2012). The beneficial effects on health of cinnamon are related to the chemical compounds that compose it, such as the active ingredient cinnamaldehyde, which is responsible for the smell, as well as the antioxidant, antimicrobial, and antifungal activities (SINGH et al, 2007). Boudry and Perrier (2008) stated that cinnamaldehyde induced the discharge of HCO 3 -and CL -by intestinal epithelium cells, also having an effect in the adhesion of bacteria to the intestinal microbiota.…”

Section: Resultsmentioning

confidence: 99%

Performance and hematological variables of piavuçu whose diets were supplemented with phytobiotic and probiotic additives

Lima

Cipriano²,

Júnior³

et al. 2015

Sem. Ci. Agr.

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The performance and hematologic responses of juvenile piavuçu fish (Leporinus macrocephalus) that were fed with feeds containing garlic, cinnamon, and yeast before being submitted to stress from capture were evaluated. The experiment was conducted in the Fish Nutrition Laboratory (Laboratório de Alimentação e Nutrição de Peixes), where 192 piavuçu juveniles (3.09 ± 0.8 g) were distributed among 16 tanks (170 L), with a density of 12 fish per tank. The experiment consisted of four treatments and four repetitions. Treatments included the addition of 10 g Kg -1 garlic, 10 g Kg -1 cinnamon, and 9x10 5UFC g -1 of Saccharomyces cerevisiae yeast, in addition to a control diet that included no additives. The performance, body indices, and survival of the fish were evaluated. After the performance test, the fish were submitted to stress from capture, and the effect of the additives as a stress reducer was evaluated through hematologic analyses. Better weight gain and feed conversion ratios (P≤0.05) were observed in the fish fed with diets containing garlic and cinnamon; however, no alterations were noticed in the nutritional composition of fish carcasses, regardless of the treatment they were submitted to. A reduction in the number of leukocytes of the fish submitted to stress in all treatments was verified. It is possible to conclude that diets supplemented with garlic and cinnamon at the level of 10 g Kg -1 led to a better performance, while not influencing the hematologic standards after the stress from capture. canela e 9x10 5 UFC g -1 de levedura Saccharomyces cerevisiae e uma dieta controle, sem a inclusão de aditivo. Foram avaliados o desempenho, índices corporais e sobrevivência dos peixes. Após o ensaio de desempenho os peixes foram submetidos ao estresse de captura e o efeito dos aditivos como mitigador do estresse foi avaliado por meio de análises hematológicas. Observou-se melhor ganho de peso e conversão alimentar (P≤0,05) nos peixes alimentados com as dietas contendo alho e canela, porém não foram observadas alterações na composição bromatológica da carcaça em nenhum dos tratamentos. Verificou-se redução nos números de leucócitos dos peixes submetidos ao estresse em todos os tratamentos. Conclui-se que dietas suplementadas com alho e canela ao nível de 10 g Kg -1 apresentaram melhor desempenho, não influenciando nos parâmetros hematológicos após o estresse de captura.

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Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses

Cited by 75 publications

References 4 publications

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils

Potentiation of antifungal activity of amphotericin B by essential oil fromCinnamomum cassia

Performance and hematological variables of piavuçu whose diets were supplemented with phytobiotic and probiotic additives

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