Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

Attieh, Hanadi; Lafi, Saleh Abu; Jaber, Suhair; Abu-Remeleh, Qassem; Lutgen, Pierre; Akkawi, Mutaz

doi:10.5897/jmpr2015.5931

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…Absorbance of the concentration series was measured at 310 nm. A graph of absorbance at 310 nm vs concentration of cinnamon extract was plotted (Akkawi et al, 2015). Absorbance of the supernatants which remained after the separation of the product containing pellets, were measured at 310 nm.…”

Section: Characterization Of Microparticlesmentioning

confidence: 99%

Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties

Wanniarachchi,

Sathsarani,

Jayawardena

et al. 2023

BIOMEDNATPROCH

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Conventional medicine that is being used to treat diabetes exert adverse side effects and therefore scientists have focused on natural hypoglycemic agents. “Sri Wijaya” (CCSW) is an accession of Cinnamomum zeylanicum, which shows higher hypoglycemic activity. Pressured water extract of its dried quills can be used as an antidiabetic nutraceutical. Higher stability, ease of storage and transportation, make powder form nutraceuticals more preferred. The objective of this study was to develop cinnamon encapsulated microparticles as a powder form nutraceutical with higher hypoglycemic activity. Four different products were synthesized. Two of them were synthesized using bovine serum albumin (BSA) (8.8 % (w/v), pH=5) in the presence of citric acid and ascorbic acid as cross-linking agents separately. The other products were synthesized using BSA (20 mg/ mL, pH=9) in the presence of same cross-linking agents. Antidiabetic activity of the products was determined using alpha-amylase and alpha glucosidase inhibition assays and compared with that of crude cinnamon extract and positive control acarbose. Since the product synthesized using BSA (20 mg/ mL, pH=9) and citric acid showed the highest alpha amylase inhibition activity, solubility, cinnamon loading percentage and cinnamon entrapment efficiency those conditions were concluded as the optimum conditions required to synthesize microparticles with higher hypoglycemic activity. Particle size, polydispersity index, and zeta potential of that product were 1.281 ± (0.004) µm, 0.460 ± (0.018) and -1.09 ± (0.03) mV respectively. According to the SEM image, microparticles have a spherical morphology. The UV-visible spectrum and the FT-IR spectrum confirm the entrapment of cinnamon compounds.

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Section: Characterization Of Microparticlesmentioning

confidence: 99%

Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties

Wanniarachchi,

Sathsarani,

Jayawardena

et al. 2023

BIOMEDNATPROCH

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“…20,21 Previous studies have shown that cinnamic acid affects the in vitro growth of Plasmodium falciparum and the permeability of the membrane of malaria-infected erythrocytes. 22 The administration of quercetin to animals undergoing acute stress suppressed activation of the hypothalamic-pituitary-adrenal (HPA) axis, which was a significant component of the stress response and played a major role in the aetiology of stress-related pathologies.…”

Section: Hplc Analysismentioning

confidence: 99%

HPLC-MS Analysis and evaluation of Antioxidant and Anti-Inflammatory Potential of Cinnamomum cassia Extract

2023

TJNPR

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IntroductionRecently, a new concept has invaded the biological and medical sciences, "oxidative stress", where the cell no longer controls the excessive presence of toxic oxygen radicals. 1 The overproduction of the latter beyond the antioxidant capacities of biological systems gives rise to oxidative stress, which is implicated in the appearance of several diseases such as arteriosclerosis, cancer, inflammatory diseases, ischemia and ageing. Inflammation is usually a beneficial process: its purpose is to eliminate the pathogen and repair tissue damage. However, synthetic anti-inflammatory or antioxidant chemical substances are always accompanied by undesirable side effects, while phytochemicals are beneficial and without side effects. 2 Utilizing various medicinal plant parts (such as roots, leaves, seeds, bark, fruits, or flowers) offers a solution. Medicinal and aromatic plants and even cultivated or spontaneous spice plants have exciting biological properties which find application in various fields, including medicine, pharmacy, cosmetology and agriculture. 3 Plant extracts from the Cinnamomum cassia species, used in Chinese medicine, are among the available natural resources.

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“…Study done by Attieh A. Hanadi et. al set up that, cinnamon's crude watersoluble extracts capacity to suppress β-hematin configuration ( malaria pigment/ hemozoin) in vitro [7].…”

Section: Study Done By Yeti Nurhayati and Tresiamentioning

confidence: 99%

Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite

Hamad

Noor

Kashif

et al. 2021

JPRI

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Medicinal plants, recognized and employed in conventional medicine practices since prehistoric era. Plants produce thousands of chemical substances for functions counting defence against insects, fungi, bacterial and parasitic diseases. Malaria is most widespread parasitic infection , it caused by coccidian protozoa of the genus plasmodium , four species are mostly infect human, P. falciparum, P. vivax, P. malriae and P. ovale, Majority of malaria cases resulted from P. falciparum and P. vivax. Uric acid regarded as one of the damaging molecular patterns of malaria parasite infection, and in this review we discussed the potential role of medicinal plants used as antimalarial to diminish the level of uric acid in gout patients. These may suggest that most of the complication associated with malaria, may attributed to amplified level of uric acid . Experimental studies recommended.

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Cinnamon bark water-infusion as an in-vitro inhibitor of -hematin formation

Cited by 8 publications

References 16 publications

Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties

Synthesis and Characterization of Cinnamon Loaded BSA Microparticles with Antidiabetic Properties

HPLC-MS Analysis and evaluation of Antioxidant and Anti-Inflammatory Potential of Cinnamomum cassia Extract

Medicinal Plants Explain the Significant Role of Uric Acid for Malaria Parasite

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