Cinnamon free phenolic extract regulates glucose absorption in intestinal cells by inhibiting glucose transporters

Liu, Yaoyao; Pang, Daorui; Xing, Dongxu; Wang, Weifei; Li, Qian; Li, Erna; Zou, Yuxiao

doi:10.1016/j.fbio.2023.102405

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…A total of 145 phenolic compounds were identified in CP, with the main components being procyanidin B3 (3262.66 ± 176.82 µg/mL dry weight), procyanidin B2 (2592.68 ± 33.84 µg/mL dry weight), procyanidin A2 (417.47 ± 17.80 µg/mL dry weight), B1 (282.26 ± 12.44 µg/mL dry weight), procyanidin C1 (112.59 ± 10.78 µg/mL dry weight), (−)-epicatechin (795.53 ± 68.80 µg/mL dry weight), (−)-catechin (339.29 ± 35.01 µg/mL dry weight), quercitrin (182.81 ± 5.69 µg/mL dry weight), theaflavin (124.87 ± 4.97 µg/mL dry weight), kaempferitrin (106.45 ± 1.35 µg/mL dry weight), and avicularin (100.96 ± 5.84 µg/mL dry weight). The highest concentration was procyanidin B3, followed by procyanidin B2 and (−)-epicatechin [16]. Previous animal studies have suggested that procyanidin oligomers may be responsible for the antidiabetic activity of cinnamon [17].…”

Section: Discussionmentioning

confidence: 92%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

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The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose.

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Section: Discussionmentioning

confidence: 92%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

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“… Li et al, 2016 ) and procyanidins derivatives in cinnamon free phenolic extract (Y. Liu et al, 2023 ). These findings suggested that the suppressive effect of procyanidins on glucose transport was related to their structural characteristics, such as linkage type and degree of polymerization.…”

Section: Introductionmentioning

confidence: 99%

Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins inhibit intestinal glucose transport in human Caco-2 cells

Wang,

Mao,

et al. 2024

Front. Pharmacol.

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Background: The hypoglycemic effects of Chinese bayberry leaves proanthocyanidins (BLPs) have been demonstrated. It is unclear, nevertheless, whether BLPs reduced postprandial blood glucose levels by regulating glucose uptake and glucose transport.Method: This study investigated the effect of BLPs (25, 50, and 100 μg/mL) on glucose uptake and glucose transport in human intestinal epithelial cells (Caco-2 cells). The uptake of 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose (2-NBDG) and disaccharidases activity in Caco-2 cells were measured. The glucose transport ability across the cell membrane was determined using the established Caco-2 monolayer model. The transcript and protein levels of key glucose transporters were analyzed using real-time quantitative polymerase chain reaction (RT-qPCR) and western blotting, respectively.Results: The results showed that BLPs significantly decreased glucose uptake and disaccharidases activity (p < 0.05). Otherwise, BLPs treatment obviously inhibited glucose transport across the Caco-2 monolayer in both simulated-fast (5 mM glucose) and simulated-fed (25 mM glucose) conditions. It was attributed to the suppression of glucose transporter2 (GLUT2) and sodium-dependent glucose cotransporter 1 (SGLT1) by BLPs. BLPs were found to significantly downregulated the transcript level and protein expression of glucose transporters (p < 0.05). Meanwhile, the mRNA expression of phospholipase C (PLC) and protein kinase C (PKC) involved in the signaling pathway associated with glucose transport were decreased by BLPs.Conclusion: These results suggested that BLPs inhibited intestinal glucose transport via inhibiting the expression of glucose transporters. It indicated that BLPs could be potentially used as a functional food in the diet to modulate postprandial hyperglycemia.

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The synergistic lipogenesis inhibition and molecular mechanism of polyphenols and polysaccharides from mulberry leaf

Zou,

Shi,

Liu

et al. 2024

Food Bioscience

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Cinnamon free phenolic extract regulates glucose absorption in intestinal cells by inhibiting glucose transporters

Cited by 6 publications

References 33 publications

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins inhibit intestinal glucose transport in human Caco-2 cells

The synergistic lipogenesis inhibition and molecular mechanism of polyphenols and polysaccharides from mulberry leaf

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