Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor

López, José J.; Jardín, Isaac; Salido, Ginés M.; Rosado, Juan A.

doi:10.1016/j.lfs.2008.03.009

Cited by 30 publications

(25 citation statements)

References 59 publications

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“…Cinnamtannin B1 has great antioxidant activity, including a scavenging capacity with respect to DPPH free radicals, as well as inhibition of lipid peroxidation and nitric oxide . In addition, cinnamtannin B1 shows antithrombotic actions via inhibition of endogenous reactive oxygen species generation in platelets, which may reduce cardiovascular complications in type 2 diabetes . Compared with the above‐mentioned studies, CoTE contained cinnamtannin B1 and parameritannin A1 and may have the potential for in vivo antihyperglycemic and antioxidant activities.…”

Section: Resultsmentioning

confidence: 99%

Structural characterization and bioactivity of proanthocyanidins from indigenous cinnamon (Cinnamomum osmophloeum)

Lin

Hsu

et al. 2016

J Sci Food Agric

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Section: Resultsmentioning

confidence: 99%

Structural characterization and bioactivity of proanthocyanidins from indigenous cinnamon (Cinnamomum osmophloeum)

Lin

Hsu

et al. 2016

J Sci Food Agric

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“…Since excessive inflammation in the surface of the wound and the disturbance of the skin layer structure of wound tissues were also not observed in the treatment of cinnamtannin B-1, we assumed it may be attributed to the anti-inflammatory effect of MSCs. Cinnamtannin B-1 has been reported to exhibit antioxidant and antimicrobial activities, as well as antiplatelet aggregation [ 17 – 19 ]. These activities may have protective effects on damaged tissues and the microenvironment of wounds.…”

Section: Discussionmentioning

confidence: 99%

“…We reported that EMPB contained protocatechuic and salicylic acids, as well as cinnamtannin B-1, which we demonstrated, could be responsible for the main in vitro chemotactic activity of the extract among these other compounds. Cinnamtannin B-1 possesses several phenolic hydroxyl groups and is reported to exhibit antioxidant property, antimicrobial activities, and anti-platelet aggregation [ 17 – 19 ] that may protect damaged tissues in wounds [ 20 ]. However, the effects of cinnamtannin B-1 on the migration activity of MSCs in vivo and wound healing in mice remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice

et al. 2015

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Substances that enhance the migration of mesenchymal stem cells to damaged sites have the potential to improve the effectiveness of tissue repair. We previously found that ethanol extracts of Mallotus philippinensis bark promoted migration of mesenchymal stem cells and improved wound healing in a mouse model. We also demonstrated that bark extracts contain cinnamtannin B-1, a flavonoid with in vitro migratory activity against mesenchymal stem cells. However, the in vivo effects of cinnamtannin B-1 on the migration of mesenchymal stem cells and underlying mechanism of this action remain unknown. Therefore, we examined the effects of cinnamtannin B-1 on in vivo migration of mesenchymal stem cells and wound healing in mice. In addition, we characterized cinnamtannin B-1-induced migration of mesenchymal stem cells pharmacologically and structurally. The mobilization of endogenous mesenchymal stem cells into the blood circulation was enhanced in cinnamtannin B-1-treated mice as shown by flow cytometric analysis of peripheral blood cells. Whole animal imaging analysis using luciferase-expressing mesenchymal stem cells as a tracer revealed that cinnamtannin B-1 increased the homing of mesenchymal stem cells to wounds and accelerated healing in a diabetic mouse model. Additionally, the cinnamtannin B-1-induced migration of mesenchymal stem cells was pharmacologically susceptible to inhibitors of phosphatidylinositol 3-kinase, phospholipase C, lipoxygenase, and purines. Furthermore, biflavonoids with similar structural features to cinnamtannin B-1 also augmented the migration of mesenchymal stem cells by similar pharmacological mechanisms. These results demonstrate that cinnamtannin B-1 promoted mesenchymal stem cell migration in vivo and improved wound healing in mice. Furthermore, the results reveal that cinnamtannin B-1-induced migration of mesenchymal stem cells may be mediated by specific signaling pathways, and the flavonoid skeleton may be relevant to its effects on mesenchymal stem cell migration.

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“…Recent studies have reported that cinnamtannin B-1 reduces endogenous ROS production stimulated by thrombin, modulates Ca 2+ mobilization in human platelets, 21 and significantly reduces the oxidant action of H 2 O 2 by the decrease in the oxidation of the redox sensitive dye CM-H 2 DCFDA on CCK-8-evoked responses in mouse pancreatic acinar cells. 22 In addition, our previous study have determined that cinnamatannin B-1 (10) is a major compound of O. japonica.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Constituents from the Rhizomes ofOsmunda japonicaThunb and Their Anti-oxidant Activity

et al. 2017

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− Eleven compounds (1-11) were isolated from the rhizomes of Osmunda japonica, and their structures were elucidated based on 1 H, 13C-NMR and LC-IT-TOF MS data. Of these compounds, all compounds (1 -11) have been previously reported, although five (6 -9, 11) have not previously been isolated from this plant. The antioxidant activities of isolated compounds (1 -11) were measured by DPPH and ABTS assays, and compound 10 showed the high antioxidant activity.

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Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor

Cited by 30 publications

References 59 publications

Structural characterization and bioactivity of proanthocyanidins from indigenous cinnamon (Cinnamomum osmophloeum)

Structural characterization and bioactivity of proanthocyanidins from indigenous cinnamon (Cinnamomum osmophloeum)

Cinnamtannin B-1 Promotes Migration of Mesenchymal Stem Cells and Accelerates Wound Healing in Mice

Phytochemical Constituents from the Rhizomes ofOsmunda japonicaThunb and Their Anti-oxidant Activity

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