Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression

Shi, Chenchen; Zhang, Haoyue; Wang, Xiaoyu; Jin, Bingliang; Jia, Qi; Li, Yiming; Yang, Ye

doi:10.1016/j.phrs.2019.104513

Cited by 24 publications

(10 citation statements)

References 42 publications

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“…IL-17 is highly expressed in synovial tissues and the synovial fluid of RA patients. IL-17 expression is closely associated with the degree of RA joint damage 12 .…”

Section: Introductionmentioning

confidence: 99%

IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

Lei

Gao

et al. 2021

Sci Rep

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by proliferation and insufficient apoptosis of fibroblast-like synoviocytes (FLSs).The biology and functions of interleukin (IL)-34 are only beginning to be uncovered. We previously demonstrated IL-34 could upregulate the expression of IL-17 in RA patients. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry of Annexin V and PI staining were performed to assess cell proliferation and apoptosis progression in RA-FLSs after stimulated with increasing concentrations of IL-34, respectively. Inflammatory cytokines and angiogenic factors were measured using quantitative real-time PCR, Western blotting and ELISA. We explored the association between IL-34 and RA-FLS proliferation and apoptosis in the context of RA. Stimulating RA-FLSs with different concentrations of IL-34 significantly promoted the proliferation and inhibited the apoptosis of RA-FLSs in a concentration-dependent manner. Neutralization of IL-17 with the IL-17 inhibitor plumbagin (PB) reduced the effects of IL-34. Proinflammatory cytokine (IL-17A IL-6 and tumor necrosis factor-α, TNF-α) and angiogenic factor (vascular endothelial growth factor, VEGF and hypoxia-inducible factor-1α, HIF-1α) expression was markedly upregulated in RA-FLSs stimulated by IL-34. PB-mediated inhibition of IL-17A also decreased the expression of IL-6, TNF-α, HIF-1α and VEGF in RA-FLSs. Taken together, these findings suggest that targeting IL-34 production in RA-FLSs may be a therapeutic strategy for RA.

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“…IL-17 is highly expressed in synovial tissues and the synovial fluid of RA patients. IL-17 expression is closely associated with the degree of RA joint damage 12 .…”

Section: Introductionmentioning

confidence: 99%

IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

Lei

Gao

et al. 2021

Sci Rep

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“…In addition, Shi et al. ( 216 ) found through experimental research that cinnamon tannin D1 downregulated inflammatory cytokines IL-17, IL-6, and IL-1β in the serum of CIA mice and upregulated IL-10 and TGF-β. ROR-γt and IL-17 mRNA levels in Th17 cells were downregulated, and Foxp3, IL-10, and TGF-β mRNA in Tregs were upregulated.…”

Section: Immunotherapy For Rheumatoid Arthritis and Postmenopausal Os...mentioning

confidence: 99%

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Wang,

Sun,

Wang

et al. 2024

Front. Immunol.

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Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) produced during differentiation of CD4+ T cells plays a key regulatory role in bone remodelling disorders in RA and PMOP. However, the specific regulatory mechanism of this imbalance in bone remodelling in RA and PMOP has not been clarified. Identifying the regulatory mechanism underlying the Th17/Treg imbalance in RA and PMOP during bone remodelling represents a key factor in the research and development of new drugs for bone immune diseases. In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which probiotics, traditional Chinese medicine compounds, and monomers maintain bone remodelling by regulating the Th17/Treg balance are expounded. The maintenance of Th17/Treg balance could be considered as an therapeutic alternative for the treatment of RA and PMOP. This study also summarizes the advantages and disadvantages of conventional treatments and the quality of life and rehabilitation of patients with RA and PMOP. The findings presented her will provide a better understanding of the close relationship between bone immunity and bone remodelling in chronic bone diseases and new ideas for future research, prevention, and treatment of bone immune diseases.

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“…Theaflavin-3,3 -digallate administrated at 10 mg/kg three times per week for 9 continuous weeks also showed the capability of reducing the expression of IL-1β, TNF-α, and IL-6, as well as MMP-1, MMP-2, and MMP-3 amounts in the synovium of a collagen-induced arthritis mouse model, chiefly by inhibiting the activation of NF-κB and the phosphorylation of P38, JNK2, and ERK [230]. Moreover, 50 mg/kg cinnamtannin D1, a polyphenolic compound isolated from Cinnamomum tamala, alleviates the severity of RA, affording reduced clinical scores and paw swelling; reduces inflammatory cell infiltration, cartilage damage in the joints, and IL-17, IL-6, and IL-1β; enhances TGF-β and IL-10 levels; reduces the frequency of Th17 cells; and enhances the frequency of Treg cells, namely by its potential to inhibit aryl hydrocarbon receptor expression and phospho-STAT3/RORγt [350]. On the other hand, 200 mg/kg cinnamon barks reduce paw volume, weight loss, and, IL-2, IL-4 and IFNγ in RA mice model [351].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Potential Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

Gonçalves,

Rodrigues,

Fonseca

et al. 2024

Pharmaceuticals

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Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental components. Globally, in 2019, 18 million people had RA. RA is characterized by persistent inflammation of the synovial membrane that lines the joints, cartilage loss, and bone erosion. Phenolic molecules are the most prevalent secondary metabolites in plants, with a diverse spectrum of biological actions that benefit functional meals and nutraceuticals. These compounds have received a lot of attention recently because they have antioxidant, anti-inflammatory, immunomodulatory, and anti-rheumatoid activity by modulating tumor necrosis factor, mitogen-activated protein kinase, nuclear factor kappa-light-chain-enhancer of activated B cells, and c-Jun N-terminal kinases, as well as other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, and innovative delivery technologies for the treatment of RA, with a focus on their possible biological activities. Nonetheless, commercialization of polyphenols may be achievable only after confirming their safety profile and completing successful clinical trials.

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Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression

Cited by 24 publications

References 42 publications

IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

IL-34 affects fibroblast-like synoviocyte proliferation, apoptosis and function by regulating IL-17

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Potential Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

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