Cinnarizine as an alternative recommendation for migraine prophylaxis: a narrative review

Comparison of the Effect of Propranolol Combination with Cinnarizine and Propranolol in the Prevention of Acute Migraine Attacks

“…In the review study Togha at al. ( 2020) it has been shown that cinnarizine drug is effective in reducing migraine attacks and the severity of headaches, which is consistent with the results of the present study (20).…”

“…Examining the average headache duration per month showed that this average was 15.45 ± 17.85 in the cinnarizine and propranolol treatment group and 16.14 ± 18.68 in the propranolol and placebo treatment group, which did not have a statistically significant difference. Examining the duration of migraine attacks in terms of hours in two treatment groups, there is a statistically significant difference (P ≤ 0.001) that the average duration of attacks in the propranolol and placebo treatment groups with values of 15.4 (4-22), is more than the cinnarizine and propranolol treatment group with values of 14.2 (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Examining the severity of headache attacks in terms of (VAS) showed that this value was 8.5 (4)(5)(6)(7)(8)(9)(10)(11) for the cinnarizine and propranolol treatment group and 9.1 (5)(6)(7)(8)(9)(10)(11) for the propranolol treatment group that this variable has a significant difference in the two groups (P ≤ 0.001).…”

Good response to rectal diazepam in refractory cases of cyclic vomiting: A case‐series and review of the literature

“…As stated, antihistamines, mainly diphenhydramine, are among the suggested prophylactic medications for CVS. 21 Cinnarizine has been reported for use as a prophylactic medication for migraine headache 22,23 and migraine associated vertigo. 24 In both of our cases, medications such as nortriptyline, amitriptyline, propranolol, and sodium valproate were ineffective and did not considerably decrease the severity, frequency, or duration of the vomiting episodes, but cinnarizine could significantly improve the symptoms.…”

Фармакотерапія Вертиго: Сучасні Дані Доказової Медицини

“…Нещодавно представлені доказові дані, що розкривають доцільність лікування вертиго за допомогою фіксованої комбінації (ФК) цинаризин/дименгідринат у зв'язку з її ефективністю та безпекою [14,15]. Результативність цієї ФК зумовлена поєднанням властивостей кожного засобу.…”