This paper presents the results of the comparative analysis of safety statistics and performance of encryption, the Strumok stream symmetric cipher (proposed for the national encryption standard of Ukraine) with other known cryptographic transformation algorithms, such as SALSA20, SNOW2.0, HC, AES with usages in stream mode, etc. They are accepted as national, international standards or are presented by the New European Schemes for Signatures, Integrity, and Encryptions (NESSI), Cryptography Research and Evaluation Committees (CRYPTREC) and others. The result of safety statistics is an analysis of the cryptographic properties of the output sequences using statistical test sets developed by the National Institute of Standards and Technology (NIST STS) and the DIEHARD tests. The result of the study of performance is the evaluation of the use of central processing unit (CPU) time to convert one octet of data to 64-bit computing platforms, following the test profile used in the eSTREAM contest.