Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement

Dey, Rajen; Bishayi, Biswadev

doi:10.1016/j.intimp.2021.107695

Cited by 9 publications

(2 citation statements)

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“…Mounting clinical evidence has revealed that S. aureus infection was closely related to anxiety (Andersson et al., 2016 ; Mursaloğlu et al., 2021 ). Dey and Bishayi ( 2021 ) have found that 2.0×10 8 CFU of S. aureus (AG‐789) could cause a series of anxiety‐ and depression‐like behaviors in a brain abscess model of Swiss albino mice. In addition, male albino mice were given 5 × 10 6 CFU of S. aureus (ATCC‐6538) intraperitoneal injection and exhibited obvious anxiety‐and depression‐like behaviors (Shal et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…In a clinical trial, increased anxiety was noted in children with atopic dermatitis, which is usually associated with S. aureus infection (Huang et al., 2021 ). A recent study has reported that S. aureus could cause a series of anxiety‐like behaviors in brain abscess mice, and these abnormal behaviors were improved by the treatment of bactericidal agent ciprofloxacin, sensitive to the S. aureus strain (Dey & Bishayi, 2021 ). However, the potential role of S. aureus infection in the development of anxiety‐like behaviors is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

et al. 2022

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Introduction:Staphylococcus aureus (S. aureus) is considered as one of the major causative agents of serious hospital-and community-acquired infections. Recent studies have reported that S. aureus infection induced neuroinflammation and was linked with some mental disorders. To evaluate the effects of S. aureus infection on abnormal behaviors, we conducted the present study.Methods: A S. aureus USA300-infected mouse model was established using bacterial suspension injection into tail vein. A series of behavioral tests were performed after USA300 infection. The expression of cytokines was detected in serum and mPFC.The number and some morphological parameters of microglia were also evaluated by immunofluorescence staining.Results: Anxiety-like behaviors, instead of locomotor activity impairment or depression-like behaviors, were observed in mice infected with S. aureus USA300 compared with control. S. aureus USA300 infection caused overexpression of IL-6, TNF-α, and IL-1β in serum, resulted in microglial over-activation and excessive release of proinflammatory cytokines in the mPFC. In addition, overexpression of TLR2 accompanied by increased GLS1 and p-STAT3 was observed in the mPFC of mice infected with S. aureus USA300. Conclusion:This study provides evidence that S. aureus USA300 infection can lead to neuroinflammation in the mPFC of mice, which may contribute to the development of anxiety.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

et al. 2022

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Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

Noor

2024

Chemistry & Biodiversity

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This review focus on the terpenoids as potential therapeutic agents for depression and anxiety disorders, which naturally found in a variety of plants and exhibit a wide range of biological activities. Among the terpenoids discussed in this review are α‐pinene, β‐caryophyllene, α‐phellandrene, limonene, β‐linalool, 1, 8‐cineole, β‐pinene, caryophyllene oxide, p‐cymene, and eugenol. All of these compounds have been studied extensively regarding their pharmacological properties, such as neuroprotective effect, anti‐inflammation, antibacterial, regulation of neurotransmitters and antioxidant effect. Preclinical evidence are reviewed to highlight their diverse mechanisms of action and therapeutic potential to support antidepressant and anxiolytic properties. Additionally, challenges and future directions are also discussed to emphasize therapeutic utility of terpenoids for mental health disorders. Overall, this review provides a promising role of terpenoids as novel therapeutic agents for depression and anxiety, with potential implications for the development of more effective and well‐tolerated treatments in the field of psychopharmacology.

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Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

Dey,

Bishayi

2023

Cell Mol Neurobiol

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Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement

Cited by 9 publications

References 87 publications

Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

Microglia activation in the mPFC mediates anxiety‐like behaviors caused by Staphylococcus aureus strain USA300

Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

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