Ciprofloxacin-Associated Pancytopenia: A Rare Side Effect of a Commonly Prescribed Medication

Rabbi, Fazal; Qayum, Ihtisham; Humayun, Omama; Khan, M. Ijaz; Khan, Uzma; Abdullah, Hafez M

doi:10.1097/mjt.0000000000001406

Cited by 2 publications

(1 citation statement)

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“…In addition, CIP is also used to prevent and treat certain travelers' diarrhea and anthrax exposure [6, 7]. However, excessive use of CIP may cause various side effects, such as nausea, diarrhea, headache, rash, central nervous system damage, peripheral neuropathy, cardiac arrhythmia, tendonitis, and tendon rupture [8, 9]. Therefore, the accurate detection of CIP is important to help identify patients' tolerance to drugs, study the metabolic pathway and pharmacokinetics of CIP, ensure environmental and food safety, and inspect drug quality compliance.…”

Section: Introductionmentioning

confidence: 99%

A ternary nucleotide–lanthanide coordination nanoprobe for ratiometric fluorescence detection of ciprofloxacin

Weng,

Li,

Liu

et al. 2024

Luminescence

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Ciprofloxacin (CIP) is a widely used broad‐spectrum antibiotic and has been associated with various side effects, making its accurate detection crucial for patient safety, drug quality compliance, and environmental and food safety. This study presents the development of a ternary nucleotide–lanthanide coordination nanoprobe, GMP‐Tb‐BDC (GMP: guanosine 5′‐monophosphate, BDC: 2‐amino‐1,4‐benzenedicarboxylic acid), for the sensitive and ratiometric detection of CIP. The GMP‐Tb‐BDC nanoprobe was constructed by incorporating the blue‐emissive ligand BDC into the Tb/GMP coordination polymers. Upon the addition of CIP, the fluorescence of terbium ion (Tb3+) was significantly enhanced due to the coordination and fluorescence sensitization properties of CIP, while the emission of the BDC ligand remained unchanged. The nanoprobe demonstrated good linearity in the concentration range of 0–10 μM CIP. By leveraging mobile phone software to analyze the color signals, rapid on‐site analysis of CIP was achieved. Furthermore, the nanoprobe exhibited accurate analysis of CIP in actual drug and milk samples. This study showcases the potential of the GMP‐Tb‐BDC nanoprobe for practical applications in CIP detection.

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Section: Introductionmentioning

confidence: 99%