Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity

Egorov, Anton R.; Kurasova, Margarita N.; Khubiev, Omar; Богданов, Н. А.; Tskhovrebov, Alexander G.; Kirichuk, Analoly A.; Хрусталев, В. Н.; Рубаник, В. В.; Kritchenkov, Andreii S.

doi:10.1016/j.mencom.2022.11.022

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…These results are consistent with previous studies where the combination of chitosan even with toxic antimicrobials such as antimicrobial peptides, ciprofloxacin, and colistin resulted in significant overall lowering of toxicity of the conjugates. 13,31,32 The lower haemolytic activity gave higher selectivity of the conjugates towards all the bacterial strains in the planktonic state (Table 2).…”

Section: Rsc Applied Polymers Papermentioning

confidence: 99%

Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms

Sahariah,

Papi,

Merz

et al. 2024

RSC Appl. Polym.

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Section: Rsc Applied Polymers Papermentioning

confidence: 99%

Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms

Sahariah,

Papi,

Merz

et al. 2024

RSC Appl. Polym.

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“…The effectiveness of chitosan as a carrier for pulmonary particulate drugs depends on its mucoadhesive properties, ability to enhance biofilm permeation, and specific targeting to sites or cells. For nanocarriers, different systems like microencapsulation and micro-nano blending have been developed to give them suitable aerodynamic properties for efficacious pulmonary aerosolization and inhalation [75][76][77]. Moreover, chitosan nanocarriers, including solid nanoparticles and liquid nanoemulsions, have been studied for their potential to deliver anti-tubercular drugs to the lungs [78].…”

Section: Chitosan Loaded Nanoparticlesmentioning

confidence: 99%

Ciprofloxacin-Loaded Inhalable Formulations against Lower Respiratory Tract Infections: Challenges, Recent Advances, and Future Perspectives

Panthi,

Fairfull-Smith,

Islam

2024

Pharmaceutics

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Inhaled ciprofloxacin (CFX) has been investigated as a treatment for lower respiratory tract infections (LRTIs) associated with cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and bronchiectasis. The challenges in CFX effectiveness for LRTI treatment include poor aqueous solubility and therapy resistance. CFX dry powder for inhalation (DPI) formulations were well-tolerated, showing a remarkable decline in overall bacterial burden compared to a placebo in bronchiectasis patients. Recent research using an inhalable powder combining Pseudomonas phage PEV20 with CFX exhibited a substantial reduction in bacterial density in mouse lungs infected with clinical P. aeruginosa strains and reduced inflammation. Currently, studies suggest that elevated biosynthesis of fatty acids could serve as a potential biomarker for detecting CFX resistance in LRTIs. Furthermore, inhaled CFX has successfully addressed various challenges associated with traditional CFX, including the incapacity to eliminate the pathogen, the recurrence of colonization, and the development of resistance. However, further exploration is needed to address three key unresolved issues: identifying the right patient group, determining the optimal treatment duration, and accurately assessing the risk of antibiotic resistance, with additional multicenter randomized controlled trials suggested to tackle these challenges. Importantly, future investigations will focus on the effectiveness of CFX DPI in bronchiectasis and COPD, aiming to differentiate prognoses between these two conditions. This review underscores the importance of CFX inhalable formulations against LRTIs in preclinical and clinical sectors, their challenges, recent advancements, and future perspectives.

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“…By encapsulating the drug, these nanocapsules can shield it from premature degradation, thus improving its stability and bioavailability. For instance, chitosan nanocapsules loaded with ampicillin have shown improved antimicrobial action against both Gram-positive and Gram-negative bacteria [ 181 , 182 , 183 , 184 ].…”

Section: The Most Important Chitosan-based Antibacterial Materialsmentioning

confidence: 99%

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Egorov,

Kirichuk,

Rubanik

et al. 2023

Materials

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This comprehensive review illuminates the various methods of chitosan extraction, its antibacterial properties, and its multifarious applications in diverse sectors. We delve into chemical, physical, biological, hybrid, and green extraction techniques, each of which presents unique advantages and disadvantages. The choice of method is dictated by multiple variables, including the desired properties of chitosan, resource availability, cost, and environmental footprint. We explore the intricate relationship between chitosan’s antibacterial activity and its properties, such as cationic density, molecular weight, water solubility, and pH. Furthermore, we spotlight the burgeoning applications of chitosan-based materials like films, nanoparticles, nonwoven materials, and hydrogels across the food, biomedical, and agricultural sectors. The review concludes by highlighting the promising future of chitosan, underpinned by technological advancements and growing sustainability consciousness. However, the critical challenges of optimizing chitosan’s production for sustainability and efficiency remain to be tackled.

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Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity

Cited by 6 publications

References 18 publications

Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms

Chitosan–saccharide conjugates for eradication of Pseudomonas aeruginosa biofilms

Ciprofloxacin-Loaded Inhalable Formulations against Lower Respiratory Tract Infections: Challenges, Recent Advances, and Future Perspectives

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

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