Ciprofloxacin for 7 days versus 14 days in women with acute pyelonephritis: a randomised, open-label and double-blind, placebo-controlled, non-inferiority trial

Influences on the start, selection and duration of treatment with antibiotics in long-term care facilities

“…We selected a cut-off of more than 7 days of treatment based on evidence that most bacterial infections can be treated with a duration of 7 days or less of antibiotics. 6,[34][35][36][37][38] We considered consecutive prescriptions for the same antibiotic to be part of the same treatment course if the drug was prescribed by the same physician, to the same patient and there was no more than 3 days between prescriptions.…”

Addressing Concerns about Changing the Route of Antimicrobial Administration from Intravenous to Oral in Adult Inpatients

“…6 However, oral antimicrobials that are typically very well absorbed have been used as initial therapy in certain situations. 7,8 Unfortunately, no universally accepted definitions exist to describe the level of severity of an infection. Often, the degree of severity is defined according to the type of infection and may vary depending on who has established the definitions.…”

“…Although prescribers could administer a single IV dose at their discretion, this study emphasized that certain severe infections can be well managed with oral antimicrobials. 8 In a meta-analysis of randomized controlled trials, transition to oral antibiotics within 2 to 4 days appeared to be as effective as continuous IV therapy in hospitalized patients with moderate to severe community-acquired pneumonia. 18 Finally, a beforeand-after study assessed the impact of a printed checklist on general medical wards to encourage physicians to change IV antibiotics to oral formulations on day 3 of therapy.…”

“…43 Another study showed a clinical cure rate of 97% among women aged 23 to 62 years with uncomplicated pyelonephritis who were treated with oral ciprofloxacin for 7 days. 8 Approximately 22% of the patients had bacteremia. Although prescribers could administer a single IV dose at their discretion, this study emphasized that certain severe infections can be well managed with oral antimicrobials.…”

Antibiotic use in Departments of Internal Medicine of Lazio

“…19,20 Similarly, for patients with ventilator associated pneumonia, 8-10 days of treatment have been proposed in substitution of the usual two weeks course [21][22][23] and the same proposal has been made for patients with cellulitis, pyelonephritis and intra-abdominal infection. [24][25][26][27][28] Moreover, IDSA/SHEA guidelines suggest using inflammatory biomarker as PCT to shorten antimicrobial exposure, especially in intensive care units. Even if PCT was measured only in 26% of PUAT and therefore underutilized, the duration of antibiotic treatment in our center was not far from the numbers highlighted in the previous studies, with a mean length among various hospitals of 9.5±6.1 SD days ranging from 6.8±4.3 SD days to 11.4±7.8 SD (P<0.05).…”