Ciprofloxacin-imprinted hydrogels for drug sustained release in aqueous media

Kioomars, Sajedeh; Heidari, Somaye; Malaekeh‐Nikouei, Bizhan; Rad, Maryam Shayani; Khameneh, Bahman; Mohajeri, Seyed Ahmad

doi:10.1080/10837450.2016.1230131

Cited by 28 publications

(13 citation statements)

References 31 publications

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“…MI technology has been successfully investigated by researchers to increase the drug loading and the drug release time from hydrogel matrices [59,[62][63][64]. There are several factors that can cause the increase in partitioning due to imprinting, including but not limited to temperature, pressure, polarity of polymerisation solvent, initiator concentration and degree of crosslinking [65,66].…”

Section: Molecular Imprintingmentioning

confidence: 99%

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Nguyen

Dowling²,

Ryan

et al. 2021

Contact Lens and Anterior Eye

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Therapeutic contact lenses for ocular drug delivery have received considerable interest as they can potentially enhance ocular bioavailability, increase patient compliance, and reduce side effects. Along with the successful in vitro and in vivo studies on sustained drug delivery through contact lenses, lens critical properties such as water content, optical transparency and modulus have also been investigated. Aside from issues such as drug stability or burst release, the potential for the commercialization of pharmaceutical-loaded lenses can be limited by the alteration of lens physical and chemical properties upon the incorporation of therapeutic or non-therapeutic components.This review outlines advances in the use of pharmaceutical-loaded contact lenses and their relevant characterization methodologies as a potential ocular drug delivery system from 2010 to 2020, while summarizing current gaps and challenges in this field. A key reference point for this review is the relevant ISO standards on contact lenses, relating to the associated characterization methodologies. The content of this review is categorized based on the chemical, physical and mechanical properties of the loaded lens with the shortcomings of such analytical technologies examined.

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Section: Molecular Imprintingmentioning

confidence: 99%

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Nguyen

Dowling²,

Ryan

et al. 2021

Contact Lens and Anterior Eye

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show abstract

“…The cumulative release amount was also higher in the end, which might be related to the weak binding effect. That's because MAA could be combined with CFX through hydrogen bonding and this kind of combination can reach an equilibrium state [49] . C. Alvarez‐Lorenzo et al .…”

Section: New Cls Hydrogels Via Rational Copolymer Designmentioning

confidence: 99%

Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

Cheng

et al. 2021

ChemNanoMat

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Pharmaceuticals delivery to the eye sites of interest via the means of contact lenses (CLs) has attracted significant research attention in recent years. Compared with the conventional formulation in eye treatment such as eye drops, CLs administration has shown remarkable advantages in overcoming the challenges involved in ocular drug delivery such as higher bioavailability, longer drug residence and better medication compliance. This review will first detail each of the material components which have been used in the context of CLs, including HEMA, MAA, DMA, NVP, EGDMA, TRIS and PDMS. The pros and cons of each material in tailoring drug release rates of different encapsulated payloads will be discussed, with special focus on their impact on the therapeutic efficiency. In addition, the advancement of recent emerging copolymer CLs hydrogels, originated from these sophisticated monomers with distinct functions, are further summarized into several synthetic strategies in the means of copolymer architecture design and function‐performance relationship in ophthalmic applications. Finally, the possible considerations for future design of multifunctional CLs hydrogels by combing material selection rationales with biological interface science are proposed.

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“…These include tissue engineering and regenerative medicine, diagnostics, cellular immobilization and the separation of biomolecules etc. [ 30 , 31 , 32 ]. Some researchers reported hydrogels designed for the delivery of antimalarials.…”

Section: Polymer-based Nanocarriers For Drug Deliverymentioning

confidence: 99%

Polymeric Nanocarriers for the Delivery of Antimalarials

Mhlwatika

Aderibigbe

2018

Molecules

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Malaria is an infectious disease caused by a protozoan parasite which is transmitted by female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world’s population is at risk of being infected by malaria. This mainly includes children, pregnant women and people living with chronic diseases. The main factor that has contributed to the spread of this disease is the increase in the number of drug-resistant parasites. To overcome drug resistance, researchers have developed drug delivery systems from biodegradable polymers for the loading of antimalarials. The drug delivery systems were characterized by distinct features such as good biocompatibility, high percentage drug encapsulation, reduced drug toxicity and targeted drug delivery. In this review article, we highlight the various types of drug delivery systems developed from polymeric nanocarriers used for the delivery of antimalarials.

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Ciprofloxacin-imprinted hydrogels for drug sustained release in aqueous media

Cited by 28 publications

References 31 publications

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Pharmaceutical-loaded contact lenses as an ocular drug delivery system: A review of critical lens characterization methodologies with reference to ISO standards

Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

Polymeric Nanocarriers for the Delivery of Antimalarials

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