Ciprofloxacin in hospital effluent: Degradation by ozone and photoprocesses

Vasconcelos, Tibiriçá G.; Kümmerer, Klaus; Henriques, Danielle M.; Martins, Ayrton F.

doi:10.1016/j.jhazmat.2009.03.143

Cited by 107 publications

(40 citation statements)

References 38 publications

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“…It is used to fight against human and veterinary diseases as well as to treat different types of bacterial infections (Vasconcelos et al, 2009;Jiang et al, 2012;Jiang et al, 2013a;Rakshit et al, 2013;Zaviska et al, 2013;Zhou and Jiang, 2015). This antibiotic acts by inhibiting essential enzyme function for DNA production (Le-Minh et al, 2010); it has been identified among the top ten of high priority pharmaceuticals associated to the water cycle in general and as a key priority substance for an EU project on the elimination of pharmaceutical residues from point sources in the healthcare sector (Jiang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…CIPRO was found in wastewater treatment plant effluents at concentrations of 313-568 ng l -1 and up to 124.5 µg l -1 in hospital sewage water (De Witte et al, 2009). Although, the presence of trace levels (ng l -1 ) of CIPRO in wastewater effluents, receiving waters and drinking water sources led to negative impacts on ecological and human health (Comerton et al, 2008;Vasconcelos et al, 2009;Wu et al, 2013), effective removal of this compound from discharge streams to the environment becomes an important issue (Sun et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

2016

Global NEST Journal

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This study investigated the removal of ciprofloxacin (CIPRO) from aqueous solution at a concentration of 10 mg l -1 and the permeate flux behavior during dead-end stirred-cell filtration system using six type of commercially available loose and tight NF membranes (NP010, NP030, NF90, NF270, CK3001 and DS-5DK). The rejection of CIPRO and permeate flux value were evaluated according to the effects of different parameters such as volume reduction factor (VRF), membrane type, transmembrane pressure (TMP) and pH. Contact angle and SEM measurements were also performed for the analysis of the pollution occurring in the pores and on the surfaces of the membranes. Filtration experiments for all membranes used indicated that the flux reached the steady state at VRF 3. CIPRO rejection was found to vary especially with both pH and membrane tightness. Despite the fact that, the loose NF membranes showed poor and variable CIPRO removal, the highest rejection was obtained with NF90 tight membrane at the original pH value (pH 5.65) and 10 bar of applied pressure. NF90 membrane achieved 98.3% TOC, 98.9% COD, 96.9% TDS and 95.7% Ec rejections at 24.39 l m -2 h -1 permeate flux at the predefined operating conditions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

2016

Global NEST Journal

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“…Dada a baixa eficiência dos métodos convencionais e devido ao longo tempo de exposição à radiação ultravioleta necessário para a degradação de quinolonas, 11,14,58,59,[63][64][65][66][67][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86] conforme apresentado na Tabela 4, torna-se importante o estudo e a avaliação de tratamentos avançados.…”

Section: -69unclassified

“…31,67,72,82,108,127 Rivas et al 113 concluíram que, mesmo que o processo de ozonização tenha sido capaz de degradar rapidamente 90% da norfloxacina presente no efluente, 70% do teor de carbono orgânico total inicial continuou presente na solução, devido aos intermediários formados, os quais poderiam contribuir para a atividade antimicrobiana residual da solução.…”

Section: Ozôniounclassified

Occurrence and Degradation of Quinolones by Advanced Oxidation Processes

Rodrigues-Silva¹,

Maniero²,

Peres³

et al. 2014

Química Nova

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OCCURRENCE AND DEGRADATION OF QUINOLONES BY ADVANCED OXIDATION PROCESSES. In this review, the presence of quinolones in the environment, their risks and the available processes for water decontamination were addressed. Their occurrence in surface waters and also in soil raises concerns about the risk of the development of resistant bacteria and other potential chronic effects. AOPs (UV/H 2 O 2 , Fenton, photo-Fenton, and UV/TiO 2 ) and ozonation proved effective for degrading these emerging contaminants due to hydroxyl radical formation, surpassing the efficacy of conventional methods. In addition, the main degradation mechanisms of these drugs as well as data on residual biological activity were analyzed.Keywords: antimicrobials; degradation mechanisms; toxicity. INTRODUÇÃOAntimicrobianos são definidos como compostos naturais, sinté-ticos ou semi-sintéticos, cuja finalidade é prevenir ou tratar doenças infecciosas causadas por micro-organismos patogênicos, 1 tanto nos seres humanos como na medicina veterinária. Visto que não são totalmente metabolizados durante o uso terapêutico, os antimicrobianos estão presentes no esgoto doméstico principalmente como resultado da excreção humana. O uso de antimicrobianos na atividade pecuária contribui, também, para a sua introdução no meio ambiente, como resultado de processos de manufatura, disposição irregular ou excreção metabólica.2 Dessa forma, esses compostos são continuamente lançados no ambiente e, considerando sua característica recalcitrante de difícil remoção/degradação, são considerados pseudopersistentes.Existem aproximadamente onze diferentes classes de antimicrobianos, 3 que se diferenciam por sua estrutura química ou mecanismos de ação no tratamento específico de determinado patógeno. As quinolonas, antimicrobianos sintéticos, são eficientes no tratamento de infecções por bactérias Gram-positivas e Gram-negativas e são largamente empregadas tanto na medicina humana como veteriná-ria. Bactérias Gram-negativas são aquelas que possuem uma parede celular com poucas camadas de peptideoglicana e uma segunda membrana de lipopolissacarídeo. No processo de coloração, a lavagem com álcool rompe a camada externa de lipopolissacarídeo e o corante é removido por meio da camada de peptideoglicana. Consequentemente, as células Gram-negativas permanecem incolores até serem coradas com a safranina (segundo corante), adquirindo tonalidade rosa-avermelhada. Como exemplo, pode-se citar: Pseudomonas aeruginosa (causadora de infecções no aparelho pulmonar, urinário e respiratório), Escherichia coli (causadora de infecções urinárias) e Salmonella (causadora de intoxicações alimentares). As bactérias Gram-positivas, como por exemplo, a Streptococcus pneumoniae, possuem uma parede com mais camadas de peptideoglicana que as bactérias Gram-negativas. Empregando-se a coloração de Gram, apresentam-se com coloração púrpura quando fixadas com cristal violeta (primeiro corante), uma vez que essas bactérias retêm esse corante mesmo quando expostas ao álcool. 4,5 Dentre os principais riscos ...

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“…As previously described, the HWW flow rate was estimated to be 190 m 3 per day. 34 A worst case scenario was assumed for the PEC calculations. 35,36 Other important RA parameter is the risk quotient (RQ), which is estimated by the PEC/PNEC and MEC/PNEC ratios.…”

Section: First Attempt At a Risk Assessmentmentioning

confidence: 99%

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater

Wilde¹,

Kümmerer²,

Martins³

2012

J. Braz. Chem. Soc.

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O presente estudo avalia, preliminarmente, o risco da exposição ambiental a β-bloqueadores em efluente de um hospital universitário (Hospital Universitário de Santa Maria (HUSM), Rio Grande do Sul). Propranolol mostrou o maior quociente de risco (0,56). A ocorrência de β-bloqueadores foi avaliada com auxílio de metodologia de SPE-HPLC-FLD (extração por fase sólida-cromatografia líquida de alta eficiência com detecção por fluorescência) otimizando-se multivariadamente as variáveis pH da amostra, pH da água e a razão entre metanol:acetonitrila:ácido fórmico. As concentrações médias de atenolol, metoprolol e propranolol medidas durante o período de uma semana foram de 2,45 ± 1,14, 4,67 ± 1,63 e 0,70 ± 0,88 μg L -1 no efluente do pronto atendimento, 0,95 ± 0,68, 0,70 ± 0,33 e 0,315 ± 0,62 μg L -1 no efluente geral do hospital e 1,26 ± 0,47, 1,27 ± 0,35 e 0,56 ± 0,47 μg L -1 no córrego receptor, respectivamente. Propranolol mostrou razão MEC/PNEC > 1 (MEC: concentração ambiental mensurada e PNEC: concentração predita que não causa efeito), exigindo maior atenção em termos de toxicidade. A ocorrência de β-bloqueadores e o risco ambiental associado demonstram a necessidade de um sistema mais eficiente de tratamento do efluente hospitalar.This preliminary study evaluated an assessment of the risks arising from environmental exposure to β-blockers from wastewater of an university hospital (University Hospital of Santa Maria (HUSM), Rio Grande do Sul State, Brazil). Propranolol showed the highest risk quotient (0.56). The occurrence of β-blockers was evaluated using an analytical procedure SPE-HPLC-FLD (solid phase extraction-high performance liquid chromatography with fluorescence detection), optimizing the variables sample pH, water pH, and methanol:acetonitrile:formic acid ratio of the elution stage. The average concentrations of atenolol, metoprolol and propranolol for a sampling period of one week were 2.45 ± 1.14, 4.67 ± 1.63 and 0.70 ± 0.88 μg L -1 in the 'Emergence' sewage; 0.95 ± 0.68, 0.70 ± 0.33 and 0.315 ± 0.62 μg L -1 in the 'HUSM general' sewage and 1.26 ± 0.47, 1.27 ± 0.35 and 0.56 ± 0.47 μg L -1 in the 'Receiving waters', the receptor stream of the effluents, respectively. Propranolol showed an MEC/PNEC ratio > 1, and thus requires more attention in terms of toxicity. The occurrence of β-blockers and the associated environmental risks demonstrate the need of a more efficient treatment system for the hospital wastewater.

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Ciprofloxacin in hospital effluent: Degradation by ozone and photoprocesses

Cited by 107 publications

References 38 publications

Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

Occurrence and Degradation of Quinolones by Advanced Oxidation Processes

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater

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Ciprofloxacin in hospital effluent: Degradation by ozone and photoprocesses

Cited by 107 publications

References 38 publications

Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

Investigation of ciprofloxacin removal from aqueous solution by nanofiltration process

Occurrence and Degradation of Quinolones by Advanced Oxidation Processes

Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of &#946;-blockers in hospital wastewater

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Multivariate optimization of analytical methodology and a first attempt to an environmental risk assessment of β-blockers in hospital wastewater