Ciprofloxacin-lnduced Toxic Epidermal Necrolysis: A Case Report

Abstract

Toxic epidermal necrolysis (TEN) is an uncommon fulminating mucocutaneous disease associated with marked morbidity and mortality. While sometimes idiopathic, TEN is frequently associated with drug administration. We report a well-documented fatal case of ciprofloxacin-induced TEN in a 50-year-old man treated for a bacterial infection of lower extremity venous stasis ulcers. To our knowledge, a total of 6 cases have been reported in the literature documenting an association between oral ciprofloxacin administration and TEN or Stevens-Johnson syndrome. The patient in this case had no prior medical conditions known to cause TEN, was not being treated with any medication other than ciprofloxacin (500 mg b.i.d.) and developed the clinical symptoms of TEN in a time course compatible with drug-induced TEN. This case provides strong evidence for the culpability of ciprofloxacin in the development of TEN.

Toxic epidermal necrolysis and agranulocytosis: Rare adverse effects of ciprofloxacin

“…There have been reports in the past regarding the fatal outcome of ciproß oxacin induced TEN. [8,9] We did not use corticosteroids or other immunosuppressive drugs and still the outcome was favorable.…”

Ciprofloxacin-Induced Toxic Epidermal Necrolysis in a Patient with Systemic Lupus Erythematosus

“…The patient had taken no other medication except hydrochloroquine, which she had already been taking for several months.There is one recent report that links hydroxychloroquine with toxic epidermiolyis [12]. However, the use of this drug for more than 1 month before onset of symptoms of toxic epidermiolysis makes it an unlikely candidate for the cause of this disease [8]. We report here the ninth case of TEN after administration of ciprofloxacin.…”

“…The mortality rate of TEN ranges from 20-70% [2]. TEN is often a drug-induced reaction and virtually any drug class appears capable of provoking it [1].To our knowledge, nine cases of ciprofloxacin-induced TEN have been reported before [3][4][5][6][7][8].…”

Oral Involvements of Hypersensitivity Reactions to ChemotherapyDrugs in Immunocompromised Child Patient: A Case Report

“…While sometimes idiopathic, TEN is frequently associated with drug administration (Table 1). 10 Intra-orally, there is widespread painful blistering and ulceration of all mucosal surfaces.…”