2023
DOI: 10.1002/adhm.202301747
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Ciprofloxacin‐Loaded, pH‐Responsive PAMAM‐Megamers Functionalized with S‐Nitrosylated Hyaluronic Acid Support Infected Wound Healing in Mice without Inducing Antibiotic Resistance

Guimei Jiang,
Renfei Wu,
Sidi Liu
et al.

Abstract: Antimicrobial‐resistant bacterial infections threaten to become the number one cause of death by the year 2050. Since the speed at which antimicrobial‐resistance develops is exceeding the pace at which new antimicrobials come to the market, this threat cannot be countered by making more, new and stronger antimicrobials. Promising new antimicrobials should not only kill antimicrobial‐resistant bacteria, but also prevent development of new bacterial resistance mechanisms in strains still susceptible. Here, PAMAM… Show more

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Cited by 4 publications
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“…The physiological importance of carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H 2 S) has been demonstrated in the benefits they offer in managing bacterial infections. Among them, NO, an endogenous gas molecule, exhibits bactericidal properties while maintaining normal tissue integrity .…”
mentioning
confidence: 99%
“…The physiological importance of carbon monoxide (CO), nitric oxide (NO), and hydrogen sulfide (H 2 S) has been demonstrated in the benefits they offer in managing bacterial infections. Among them, NO, an endogenous gas molecule, exhibits bactericidal properties while maintaining normal tissue integrity .…”
mentioning
confidence: 99%