Ciprofloxacin-Loaded Silver Nanoparticles Efficacy on Chronic Toxoplasmosis Infected Mice

Abstract

Toxoplasmosis is one of the commonest health problems especially in immunocompromised patients. The study evaluated the effect of ciprofloxacin loaded on silver nanoparticles in treating mice experimentally infected toxoplasmosis treatment of. This study was conducted on mice infected with (ME 49 Toxoplasma gondii strain). Sixty mice were divided into: GI: 5 non infected non-treated mice (normal control). GII: 10 infected non-treated mice (infected control). GIII: 10 infected mice treated with Spiramycin 100mg/kg (drug controls). GIV: 10 infected mice treated with ciprofloxacin 100mg/kg. GV: 10 infected mice treated with ciprofloxacin loaded silver nano-particles (100mg/kg ciprofloxacin+2.5µg/kg silver nano). GVI: 10 infected mice treated with silver nanoparticles (2.5µg/kg). GVII: 5 non-infected mice treated with silver nanoparticles (2.5µg/kg). Mice were sacrificed 8 weeks (experimental end) and brain and liver from each group were processed for histopathological studies of the cysts numbers, and sizes.