Ciprofloxacin-mediated inhibition of tenocyte migration and down-regulation of focal adhesion kinase phosphorylation

Tsai, Wen–Chung; Hsu, Chih‐Chin; Chen, Huang‐Chung; Hsu, Yuan-Ming; Lin, Miao-Sui; Wu, Chin-Wen; Pang, Jong‐Hwei S.

doi:10.1016/j.ejphar.2009.02.006

Cited by 24 publications

(20 citation statements)

References 24 publications

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“…In addition, the evidence is from case reports rather than trials. However, since studies show that ciprofloxacin can effect tenocyte development ex vivo and in rats,12 16 it would seem to be a sensible precaution to avoid ciprofloxacin in elite athletes.…”

Section: Discussionmentioning

confidence: 99%

“…As a non-absorbed (<0.4%) agent,12 it has fewer side effects,18 though it may not be as effective as ciprofloxacin. One double-blind randomised controlled trial18 showed 72% protection against TD using rifaximin, whereas ciprofloxacin is quoted as being 90–95% protective 7.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, frequent hand washing, especially before eating, is advised 4 7. Ciprofloxacin is an appropriate antibiotic for prophylaxis against the likely pathogens in India, but it has a possible association with tendon disease8 9 10 11 12 and is therefore usually avoided in athletes. Most courses of TD are self-limiting and only require fluid and electrolyte replacement 4 6 7 13.…”

mentioning

confidence: 99%

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Setting standards for the prevention and management of travellers’ diarrhoea in elite athletes: an audit of one team during the Youth Commonwealth Games in India

Tillett

Loosemore

2009

Br J Sports Med

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The incidence of TD was less during the event than on the reconnaissance trip. The relative contribution to this reduction in strict hygiene guidelines as compared with potentially improved catering hygiene arrangements is unknown. Prophylactic ciprofloxacin also reduced the incidence of TD but it is probably not appropriate for use in elite athletes. Rifaximin may be an alternative for this group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Setting standards for the prevention and management of travellers’ diarrhoea in elite athletes: an audit of one team during the Youth Commonwealth Games in India

Tillett

Loosemore

2009

Br J Sports Med

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“…Ciprofloxacin causes cell-cycle arrest at G2/M phase by down-regulating protein and mRNA levels of cyclin B and cyclin dependent kinase-1 (CDK-1), and suppressing expression of check point kinase 1(CHK-1) protein (Tsai et al 2008). Ciprofloxacin also decreases tenocyte migration by inhibiting focal adhesion kinase phosphorylation (Tsai et al 2009). …”

Section: Ultrastructural Degenerative Changesmentioning

confidence: 99%

“…FQ associated ultrastructural and biochemical changes in tendon cells. Ciprofloxacin Inhibition of focal adhesion kinase phosphorylation Tsai et al 2009 natural or artificial ultraviolet, leading to formation and accumulation of intracellular reactive oxygen species (ROS) (Onoue et al 2009). The formation of ROS, especially singlet oxygen, was found to be responsible for FQ-induced DNA damage, which was guanine specific and FQ concentration-dependent (Hiraku and Kawanishi 2000).…”

Section: Role Of Oxidative Stress and Mitochondriamentioning

confidence: 99%

Fluoroquinolone-Induced Tendinopathy: Etiology and Preventive Measures

Kaleagasioglu

Olcay

2012

Tohoku J. Exp. Med.

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Tendinopathy is a serious health problem and its etiology is not fully elucidated. Among intrinsic and extrinsic predisposing factors of tendinopathy, the impact of therapeutic agents, especially fluoroquinolone (FQ) group antibiotics, is recently being recognized. FQs are potent bactericidal agents widely used in various infectious diseases, including community acquired pneumonia and bronchitis, chronic osteomyelitis, traveler's diarrhea, typhoid fever, shigellosis, chronic bacterial prostatitis, uncomplicated cervical and urethral gonorrhea and prophylaxis of anthrax. FQs have an acceptable tolerability range. However, many lines of evidence for developing tendinitis and tendon rupture during FQ use have resulted in the addition of a warning in patient information leaflets. FQ-induced tendinopathy presents a challenge for the clinician because healing response is poor due to low metabolic rate in mature tendon tissue and tendinopathy is more likely to develop in patients who are already at high risk, such as elderly, solid organ transplant recipients and concomitant corticosteroid users. FQs become photo-activated under exposure to ultraviolet light, and this process results in formation and accumulation of intracellular reactive oxygen species (ROS). The subsequent FQ-related oxidative stress disturbs mitochondrial functions, leading to apoptosis. ROS overproduction also has direct cytotoxic effects on extracellular matrix components. Understanding the mechanisms of the FQ-associated tendinopathy may enable designing safer therapeutic strategies, hence optimization of clinical response. In this review, we evaluate multi-factorial etiology of the FQ-induced tendinopathy and discuss proposed preventive measures such as antioxidant use and protection from natural sunlight and artificial ultraviolet exposure.

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Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice

et al. 2018

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Ciprofloxacin-mediated inhibition of tenocyte migration and down-regulation of focal adhesion kinase phosphorylation

Cited by 24 publications

References 24 publications

Setting standards for the prevention and management of travellers’ diarrhoea in elite athletes: an audit of one team during the Youth Commonwealth Games in India

Setting standards for the prevention and management of travellers’ diarrhoea in elite athletes: an audit of one team during the Youth Commonwealth Games in India

Fluoroquinolone-Induced Tendinopathy: Etiology and Preventive Measures

Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice

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