Ciprofloxacin-ResistantShigella sonneiAssociated with Travel to India

ShigellaAntimicrobial Drug Resistance Mechanisms, 2004–2014

“…Of the 18 patients for whom travel to India was documented, isolates from 55.6% were resistant to ciprofloxacin, a finding that supports previous reports of importation of ciprofloxacin-resistant Shigella from India to Europe and the United States ( 11 , 12 ) and emphasizes the need to obtain travel information from patients receiving treatment for shigellosis. Furthermore, therapeutic efficiency of fluoroquinolones may be decreased because of the presence of PMQR determinants in phenotypically susceptible strains.…”

Molecular characterization of antimicrobial resistance in clinical Shigella isolates during 2014 and 2015: trends in South India

“…S. sonnei is now emerging in regions that used to be dominated by S. flexneri. 13,[15][16][17] This shift has been documented in many regions in Asia, Latin America, and the Middle East. 17,18 S. flexneri was the most common serotype in the United States in the early 1960s but was replaced by S. sonnei during 1964-1968.…”

Snippets

“…An update on vaccine-derived polioviruses worldwide, January 2014-March 2015, has been published recently. 2 Four aVDPV 2 s were isolated from AFP patients from four different states in India during this period. In addition, two VDPV isolates that escaped detection by screening assay by The Global Polio Laboratory Network have been reported from Mumbai, India.…”

“…Combination therapy with third generation cephalosporins is under discussion. 2 Management of iNTS disease is as yet not fully determined, due to lack of adequate laboratory and clinical data. Third generation cephalosporins for at least 2 weeks is the conventional therapy.…”

“…In view of this, ciprofloxacin can no longer be recommended for empiric therapy of S. sonnei infections. 2…”