Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway

Wang, Dan; Zhang, Zikun; Si, Zekun

doi:10.1590/fst.39520

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…It plays an important role in maintaining intestinal homeostasis (Wang et al, 2022;Bauer et al, 2010,). Studies have shown that NLRP3 inflammasome is closely related to the occurrence and development of IBD, especially UC, and plays an important role in inflammatory response and intestinal immune barrier function (Zhang et al, 2021a;Wang et al, 2022;Bauer et al, 2010;Wu et al, 2021). Our study determined that HACE1 suppressed Nrf2/NLRP3 signaling pathway in model of colitis.…”

Section: Discussionmentioning

confidence: 54%

“…NLRP3 inflammasome is mainly composed of NLRP3, ASC and caspase-1 (Pu et al, 2021;Lv et al, 2021). It plays an important role in maintaining intestinal homeostasis (Wang et al, 2022;Bauer et al, 2010,). Studies have shown that NLRP3 inflammasome is closely related to the occurrence and development of IBD, especially UC, and plays an important role in inflammatory response and intestinal immune barrier function (Zhang et al, 2021a;Wang et al, 2022;Bauer et al, 2010;Wu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

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The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway

QIU

NIU

et al. 2023

Food Sci. Technol

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This study was intended to elucidate the effects of HACE1 in Citrobacter rodentium-Induced Murine Colitis. Male C57BL/6 mice orally administered with 100 µLof Citrobacter rodentium DBS-100 (109 CFU mL −1 ) for 14 days. The expression of HACE1 in Citrobacter rodentium-Induced Murine Colitis was increased. HACE1 promoted inflammation and ROS levels in macrophage through the inactivation of Nrf2/NLRP3 signaling pathway. Meanwhile, si-HACE1 reduced inflammation and ROS levels in macrophage via the inhibition of Nrf2/NLRP3 signaling pathway. Sh-HACE1 reduced inflammatory responses in Citrobacter rodentium-Induced Murine Colitis through the promotion of Nrf2/NLRP3 signaling pathway. IP showed that HACE1 protein catenated with Nrf2 protein to suppress ROS-induced NLRP3 in macrophage through the promotion of Nrf2 Ubiquitination. Altogether, our data demonstrate that the inhibition of HACE1 ameliorates inflammatory responses in Citrobacter rodentium-induced Murine Colitis through the inhibition of ROS-induced mitochondrial damage by Nrf2/NLRP3. m6A promoted HACE1 stability by METTL3. Our study revealed the m6A methyltransferase METTL3 promoted HACE1 stability to promote NLRP3 activity in Citrobacter rodentium-Induced Murine Colitis by the inhibition of Nrf2.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway

QIU

NIU

et al. 2023

Food Sci. Technol

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“…One of the many organ dysfunctions brought on by sepsis is cognitive impairment, which has a major impact on the prognosis and survival of sepsis patients. The open field test and the Morris water maze tests were utilized in this experiment to measure the mice's capacity for movement and exploration and learning (Wang et al, 2022a). It was discovered that while clove might boost the activity, exploration ability, learning capacity, and cognitive ability of sick mice, these traits were all impaired in the septic mice.…”

Section: Discussionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

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Clove is a kind of food spice, which can be used as food flavoring additive. In this work, we looked at clove's impact and underlying mechanism on cognitive impairment in infected mice. By using the open field test, Morris water maze, ELISA technique, kit method, and qPCR method, the biochemical and molecular biological indices of mice were identified. Clove component composition was established using HPLC. The findings demonstrated that clove might enhance mouse survival rates in comparison to the model group and could also lengthen driving distances, standing and combing periods, target quadrant duration, and crossing periods. In the hippocampus of infected mice, clove can lower levels of TNF-α, IL-6, IL-1β, and MDA while increasing SOD and CAT activity. In the hippocampus of infected animals, clove additionally increased the mRNA expression of SIRT1 and FOXO1 and decreased the mRNA expression of NF-B and p53. Animal studies revealed that clove's impact was comparable to dexamethasone in that it might help septic mice with cognitive impairment. The analysis revealed that rutin, isoquercitrin, ferulic acid, dihydroquercetin, and quercitrin were all present in clove. It is clear that clove can help septic mice with cognitive impairment by triggering SIRT1 through its active components.

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“…According to estimates by the World Health Organization, there are approximately 422 million diabetic patients in the world, of which more than 90% have type 2 diabetes (T2DM) (Cho et al, 2018;World Health Organization, 2015). As we all know, DN is the main cause of chronic kidney disease and endstage renal disease, and it is closely related to T2DM (Ritz et al, 1999;Wang et al, 2021). In China, there are approximately 114 million people with diabetes, which greatly harms public health (Zhen et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

Zhang

Yang²,

Yu³

et al. 2022

Food Sci. Technol

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Current evidence showed that parthenolide (PN) has strong anti-inflammatory activity, but its effect on diabetic nephropathy (DN) is still unclear. In this research, high glucose (HG)-induced MPC5 cells were incubated with 5, 10 or 20 μM PN, and we found that PN incubation improved HG-induced MPC5 cells viability and apoptosis, ROS level, LDH activity and the secretion of inflammatory factors (IL-6, TNF-α and IL-1β), and inhibited the expression of DNMT1 protein, and promoted the expression of VDR, p-AKT, nephrin and podocin proteins. Lentivirus-mediated VDR overexpression vector (LV-VDR) transfection had the same effect, and LV-DNMT1 or si-VDR transfection or 100 nM AKT inhibitor MK2206 incubation reversed the effect of PN on cell functions. Research on the mechanism found that PN reduced the level of VDR methylation by reducing the enrichment of DNTM1 in the VDR promoter region under high glucose condition. In vivo, C57BL/6 mice were injected with streptozotocin (STZ) intraperitoneally to construct a DN mouse model, and 5mg/kg PN was administered intraperitoneally every other day. The results showed that PN treatment improved glomerular hypertrophy and renal fibrosis in STZ-induced mice. In general, PN regulated DNTM1-mediated VDR methylation, activated AKT, and alleviated DN.

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Circ 0006282/miR-155 reduced inflammation in diabetic nephropathy via expression of SIRT1/NLRP3 signaling pathway

Cited by 4 publications

References 28 publications

The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway

The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

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