Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52

Shi, Qi; Ma, Yuanyuan; Zhang, Xiaojie; Yin, Chao

doi:10.1111/aji.13586

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Among the family members (TPD52, TPD53, TPD54, and TPD55), TPD52 has been extensively studied due to its involvement in the malignancy of different cancer cells 50 . Numerous studies have demonstrated the upregulation of TPD52 at both the mRNA and protein levels in several cancers, including lung cancer 31 , 51 , 52 . In our study, we confirmed that TPD52 indeed acts as an oncogene and is regulated by the AR/circ-SLCO1B7/miR-139-5p signaling pathway, promoting lung cancer progression.…”

Section: Discussionmentioning

confidence: 99%

Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression

Liu¹,

Li²,

Zhou³

et al. 2023

Int. J. Biol. Sci.

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Lung cancer, as the most commonly diagnosed malignancy, still accounts for the leading cause of cancer-related deaths worldwide. The high rate of mortality and tumor recurrence has prompted clinicians and scientists to urgently explore new targets for improved treatment. Previous studies have indicated a potential role of the androgen receptor (AR) in the progression of non-small cell lung cancer (NSCLC). However, the precise mechanisms underlying this association, particularly its relation to TPD52-mediated cell invasion and cisplatin (DDP) response, have not been fully elucidated. Therefore, further investigation is necessary to gain a better understanding of these mechanisms and their potential implications for lung cancer treatment. In this study, we discovered that AR can suppress NSCLC cell invasion and increase cisplatin response by downregulating the expression of circular RNA (circRNA), specifically circ-SLCO1B7. This suppression is achieved through the direct binding of AR to the 5' promoter region of the host gene SLCO1B7. The decreased expression of circ-SLCO1B7, mediated by AR, released miR-139-5p back to the RISC (RNA induced silencing complex), where it bonds to the 3' untranslated region (3'UTR) of Tumor Protein D52 (TPD52) messenger RNA, resulting in TPD52 reduction. The in vivo data also validated the functional contribution of AR/circ-SLCO1B7/miR-139-5p/TPD52 axis to lung cancer progression. Furthermore, analysis of human NSCLC databases and clinical specimens confirmed the association of the AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway with NSCLC progression. Collectively, the results from our study suggest that AR can suppress lung cancer cell invasion and increase DDP response by modulating the circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway. Targeting this novel signaling pathway may be a new therapeutic strategy to effectively constrain NSCLC development.

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Section: Discussionmentioning

confidence: 99%

Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression

Liu¹,

Li²,

Zhou³

et al. 2023

Int. J. Biol. Sci.

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Emerging role of miR-520a in human diseases

Ahmadi,

Morshedzadeh,

Ghaderian

et al. 2024

Pathology - Research and Practice

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TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis

Miao,

Jing,

Chen

et al. 2024

CMM

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Background: Some tumors have a poor prognosis regarding TPD52 (tumor protein D52). This study aims to explore TPD52's role in the cancer process from a pan-cancer perspective. Methods: A pan-cancer analysis was conducted to investigate how TPD52 may be involved in cancer as well as its association with prognosis. Results: A variety of human cancers express TPD52 abnormally and correlate with clinical stage. There was a significant association between low expression of TPD52 and poor survival in BRCA, KIRP, LAML, LIHC, UCEC, and UVM. TPD52 alterations were most frequently amplified in pan-cancer. The co-occurrence of 10 genes alterations was found in the TPD52 altered group. There was a significant association between TPD52 expression and MSI in four cancer types and TMB in twelve cancer types. There was a significant correlation between TPD52 expression and immunerelated cell infiltration. A significant correlation was found between TPD52 expression in many tumor types and 8 immune checkpoint genes. There were signaling pathways involved in pan-cancer caused by TPD52, including endocytosis, Fc gamma Rmediated phagocytosis, and so on. TPD52 may be involved in chemotherapy and chemoresistance. Conclusion: The TPD52 gene may be important for human cancer treatment.

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Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52

Cited by 3 publications

References 44 publications

Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression

Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression

Emerging role of miR-520a in human diseases

TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis

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