circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis

Liu, Dong; Chen, Lingyun; Bai, Bin; Qi, Xiaofen; Liu, Jingnan; Qin, Shuang

doi:10.4149/neo_2021_210608n771

Cited by 17 publications

(14 citation statements)

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“…The mechanism of these differences has not been clarified yet. Secondly, the expression levels of miR-1301 in hepatocellular carcinoma ( 23 , 41 , 42 ), prostate cancer ( 20 , 21 , 43 ) and gastric cancer ( 22 , 30 ) tumors are inconsistent. The complex regulation mechanism needs to be further explored in these three cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that miR-1301 is down-regulated in 11 cancers. These tumors include esophageal cancer ( 12 , 38 , 39 ), oral squamous cell carcinoma (OSCC) ( 13 ), colorectal cancer (CRC) ( 6 , 17 , 18 , 40 ), laryngeal squamous cell carcinoma (LSCC) ( 41 ), papillary thyroid carcinoma (PTC) ( 7 , 23 , 42 ), clear cell renal cell carcinoma (ccRCC) ( 27 ), bladder cancer ( 28 ), cervical cancer ( 33 ), glioma ( 4 , 24 , 29 ), osteosarcoma ( 8 , 9 , 43 ), and CML ( 10 ). In these tumors, miR-1301 is regulated by at least 12 ncRNAs, including 3 circRNAs (MYLK, circ_0004370 and circ_0067934) and 9 lncRNAs (LINC01433, MIAT, LINC01207, RNCR3, VPS9D1-AS1, ABHD11-AS1, SNHG16, NNT-AS1, PVT1).…”

Section: The Aberrant Expression Of Mir-1301 In Cancermentioning

confidence: 99%

“…All these ceRNAs can cause the down-regulation of miR-1301 expression ( Figure 3 ). The miR-1301-related ceRNA network exists in 11 cancers, including cervical cancer ( 33 ), esophageal cancer ( 12 , 38 , 39 ), LSCC ( 41 ),CRC ( 17 , 18 ), gastric cancer ( 1 ), OSCC ( 13 ), PTC ( 23 , 26 ), bladder cancer ( 28 ), ccRCC ( 27 ), osteosarcoma ( 43 ), and glioblastoma multiforme (GBM) ( 29 ).…”

Section: The Mir-1301-related Cerna Networkmentioning

confidence: 99%

“…In OSCC, LINC01207 can also up-regulate the expression of LDHA by inhibiting miR-1301-3p, thereby promoting the growth and metastasis of OSCC cells ( 13 ). In PTC, circ_0067934 upregulates the expression of HMGB1 through sponging miR-1301-3p, thereby promoting the occurrence and development of PTC ( 23 ). In addition, STAT3 is the upstream transcription factor of lncRNA ABHD11-AS1.…”

Section: The Mir-1301-related Cerna Networkmentioning

confidence: 99%

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Aberrant Expression of miR-1301 in Human Cancer

et al. 2022

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miR-1301 is a newly discovered miRNA, which is abnormally expressed in 14 types of tumors. miR-1301 inhibits 23 target genes, forms a ceRNA network with 2 circRNAs and 8 lncRNAs, and participates in 6 signaling pathways, thereby affecting tumor cell proliferation, invasion, metastasis, apoptosis, angiogenesis, etc. Abnormal expression of miR-1301 is often associated with poor prognosis of cancer patients. In addition, miR-1301 is related to the anti-tumor effect of epirubicin on osteosarcoma and imatinib on chronic myeloid leukemia(CML) and can enhance the cisplatin sensitivity of ovarian cancer. This work systematically summarizes the abnormal expression and prognostic value of miR-1301 in a variety of cancers, depicts the miR-1301-related signaling pathways and ceRNA network, and provides potential clues for future miR-1301 research.

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Section: Discussionmentioning

confidence: 99%

Section: The Aberrant Expression Of Mir-1301 In Cancermentioning

confidence: 99%

Section: The Mir-1301-related Cerna Networkmentioning

confidence: 99%

Section: The Mir-1301-related Cerna Networkmentioning

confidence: 99%

See 2 more Smart Citations

Aberrant Expression of miR-1301 in Human Cancer

et al. 2022

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“…In addition, a few circRNAs may indirectly activate or inactivate several vital signaling pathways by suppressing miRNAs, such as the NOTCH3/GATAD2A (Yao et al, 2019), JAK/STAT/AMPK (Cui and Xue, 2020), PI3K/AKT/mTOR (Long et al, 2020), and Wnt/β-catenin signalling pathways (Bi et al, 2018;Chen et al, 2018;Long et al, 2020;Zeng et al, 2021) For instance, Cui et al observed that hsa_circ_100,721 (circDOCK1) serves as a ceRNA for miR-124, leading to dampening signal transduction of the JAK/STAT/AMPK pathway (Cui and Xue, 2020). Dong et al revealed that circ_0067934 acts as a molecular sponge for miR-1301-3p to induce malignant effects in PTC cells, resulting in the activation of PI3K/Akt and MAPK pathways (Dong et al, 2022). However, the specific mechanisms underlying these circRNA functions remain unknown and require further study.…”

Section: Function Of Circrnas In Ferroptosis and Other Mechanismsmentioning

confidence: 99%

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

Yao

Zhang²

2022

Front. Mol. Biosci.

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Thyroid cancer (TC) is the leading cause and mortality of endocrine malignancies worldwide. Tumourigenesis involves multiple molecules including circular RNAs (circRNAs). circRNAs with covalently closed single-stranded structures have been identified as a type of regulatory RNA because of their high stability, abundance, and tissue/developmental stage-specific expression. Accumulating evidence has demonstrated that various circRNAs are aberrantly expressed in thyroid tissues, cells, exosomes, and body fluids in patients with TC. CircRNAs have been identified as either oncogenic or tumour suppressor roles in regulating tumourigenesis, tumour metabolism, metastasis, ferroptosis, and chemoradiation resistance in TC. Importantly, circRNAs exert pivotal effects on TC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA-binding proteins, and translating functional peptides. Recent studies have suggested that many different circRNAs are associated with certain clinicopathological features, implying that the altered expression of circRNAs may be characteristic of TC. The purpose of this review is to provide an overview of recent advances on the dysregulation, functions, molecular mechanisms and potential clinical applications of circRNAs in TC. This review also aimes to improve our understanding of the functions of circRNAs in the initiation and progression of cancer, and to discuss the future perspectives on strategies targeting circRNAs in TC.

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CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis

Chen

Jiang

Luo

et al. 2022

Clinical Laboratory Analysis

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Background Circular RNAs (circRNAs) are implicated in carcinogenesis, including papillary thyroid cancer (PTC). Despite of previous reports regarding the high expression of circPTPRM in PTC, the role and regulatory mechanism remain to be investigated. Methods CircPTPRM and miR‐885‐5p expression were examined, and the effects on cell proliferation, migration, and invasion were also measured. Immunoblotting was performed to evaluate DNA methyltransferase 3A (DNMT3A) and the epithelial‐mesenchymal transition (EMT)‐associated proteins. Results CircPTPRM was overexpressed in PTC tissues and cell lines, which predicted poor prognosis. CircPTPRM inhibition significantly alleviated the proliferation, migration, and invasion abilities. It was subsequently confirmed that circPTPRM competed with miR‐885‐5p for DNMT3A binding. CircPTPRM promoted PTC progression via miR‐885‐5p/DNMT3A signal axis. Conclusion Our data elucidated that circPTPRM may play an oncogenic role in PTC through circPTPRM/miR‐885‐5p/DNMT3A axis

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circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis

Cited by 17 publications

References 0 publications

Aberrant Expression of miR-1301 in Human Cancer

Aberrant Expression of miR-1301 in Human Cancer

Function and Clinical Significance of Circular RNAs in Thyroid Cancer

CircPTPRM accelerates malignancy of papillary thyroid cancer via miR‐885‐5p/DNMT3A axis

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