Circ_0087862 promotes tumorigenesis and glycolysis in colorectal cancer by sponging miR-296-3p to regulate PGK1 expression

Exploring the impact of circRNAs on cancer glycolysis: Insights into tumor progression and therapeutic strategies

“…Xiao et al investigated the functional role and underlying mechanism of circ_0087862 in CRC progression [ 207 ]. Their findings demonstrated that circ_0087862 and phosphoglycerate kinase 1 (PGK1) are upregulated in CRC tissues and cells [ 207 ]. Also, miR-296-3p is downregulated in CRC, creating a potential regulatory axis.…”

“…Also, miR-296-3p is downregulated in CRC, creating a potential regulatory axis. Silencing circ_0087862 results in the suppression of cell proliferation, invasion, and glycolysis, along with promoting apoptosis in CRC cells [ 207 ]. These findings suggest that circ_0087862 is pivotal in facilitating tumorigenesis and glycolytic processes in CRC.…”

“…These findings suggest that circ_0087862 is pivotal in facilitating tumorigenesis and glycolytic processes in CRC. In the current study, circ_0087862 is identified as a sponge for miR-296-3p, indicating a direct interaction and regulation between circ_0087862 and miR-296-3p [ 207 ].…”

“…Moreover, inhibition of miR-296-3p reverses the inhibitory effects of circ_0087862 silencing on cell proliferation, invasion, and glycolysis [ 207 ]. This suggests that the functional impact of circ_0087862 in CRC is, at least in part, mediated by its interaction with miR-296-3p.…”

“…Overexpression of PGK1 counteracts the tumor-suppressive effects mediated by miR-296-3p, suggesting PGK1 as a downstream effector of this regulatory axis [ 207 ]. Knockdown of circ_0087862 inhibits tumorigenesis in vivo, emphasizing the clinical relevance and potential therapeutic impact of targeting circ_0087862 in CRC [ 207 ]. circ_0087862 is proposed to promote CRC progression through the miR-296-3p/PGK1 axis.…”