Circ_100549 promotes tumor progression in lung adenocarcinoma through upregulation of BIRC6

Chen, Feifei; Chen, Juan; Yuan, Yuan; Fang, Surong; Xie, Jing; Xu, Xiaojuan; Yang, Zhenhua; Jiang, Jianzhong

doi:10.1007/s00418-024-02275-z

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Roles and Mechanisms Of Circrna In Respiratory Cancers1

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2024

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“…A study by Chen et al. ( 96 ) demonstrated that circ-100549 serves as a ceRNA by sponging miR-95–5p to upregulate BPTF expression, thus upregulating BIRC6 expression at a transcriptional level in LUAD. In addition, other studies have shown that the GSE101684 dataset from the Gene Expression Omnibus (GEO) database and discovered that circ-PLXND1, derived from the PLXND1 gene, was upregulated in NSCLC tissues.…”

Section: Roles and Mechanisms Of Circrna In Respiratory Cancersmentioning

confidence: 99%

Roles and mechanisms of circular RNA in respiratory system cancers

Yang,

Jiao,

Zhang

et al. 2024

Front. Oncol.

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Circular RNAs (circRNAs) constitute a class of endogenous non-coding RNAs (ncRNAs) that lack a 5’-ended cap and 3’-ended poly (A) tail and form a closed ring structure with covalent bonds. Due to its special structure, circRNA is resistant to Exonuclease R (RNaseR), making its distribution in the cytoplasm quite rich. Advanced high-throughput sequencing and bioinformatics methods have revealed that circRNA is highly conserved, stable, and disease- and tissue-specific. Furthermore, increasing research has confirmed that circRNA, as a driver or suppressor, regulates cancer onset and progression by modulating a series of pathophysiological mechanisms. As a result, circRNA has emerged as a clinical biomarker and therapeutic intervention target. This article reviews the biological functions and regulatory mechanisms of circRNA in the context of respiratory cancer onset and progression.

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Section: Roles and Mechanisms Of Circrna In Respiratory Cancersmentioning

confidence: 99%