Circ_C4orf36 Promotes the Proliferation and Osteogenic Differentiation of BMSCs by Regulating VEGFA

Zhang, Zhimin; Huang, Chun-Xia; Huo, Jianzhong

doi:10.1007/s10528-022-10290-9

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…In addition, upregulated circDLGAP4 stabilized HMGA2 mRNA and increased HMGA2 expression, while the opposite results growth factor A (VEGFA) by recruiting EIF4A3. [34] CircRNA 0000775 stabilizes cell division cycle 27 (CDC27) by recruiting insulin-like growth factor 2 RBP 2 (IGF2BP2). [35] In other words, circDLGAP4 reinforced HMGA2 mRNA stability and increased HMGA2 expression by recruiting EIF4A3.…”

Section: Discussionmentioning

confidence: 99%

CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression

Bao,

Zhang,

et al. 2023

J Biochem & Molecular Tox

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Parkinson's disease (PD) is a prevalent neurodegenerative disease, and its prevalence increases steadily with age. Circular RNAs (circRNAs) are involved in various neurodegenerative diseases. Here, we aimed to explore the role of circRNA DLG‐associated protein 4 (circDLGAP4) in 1‐methyl‐4‐phenylpyridinium ion (MPP+)‐induced neuronal injury in PD. SH‐SY5Y cells were treated with MPP+ to establish PD cell models. The levels of circDLGAP4 and high mobility group AT‐hook 2 (HMGA2) in SH‐SY5Y cells were detected. SH‐SY5Y cell viability and apoptosis were detected. The levels of inflammatory damage (IL‐1β, IL‐6, TNF‐α) and oxidative stress (reactive oxygen species, lactate dehydrogenase, superoxide dismutase, and malondialdehyde)‐related factors were measured. The binding of eukaryotic initiation factor 4A3 (EIF4A3) to circDLGAP4 and HMGA2 was analyzed using RNA pull‐down or RNA immunoprecipitation. The stability of HMGA2 was detected after actinomycin D treatment, and its effects on neuronal injury were tested. CircDLGAP4 expression was decreased in MPP+‐induced SH‐SY5Y cells. CircDLGAP4 upregulation restored cell activity, decreased apoptosis, and reduced inflammatory damage and oxidative stress in PD cell models. CircDLGAP4 bound to EIF4A3 to increase HMGA2 expression and stability. Silencing HMGA2 attenuated the protective effect of circDLGAP4 overexpression. Overall, circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus increasing the mRNA stability of HMGA2 and alleviating neuronal injury in PD.

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Section: Discussionmentioning

confidence: 99%

CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression

Bao,

Zhang,

et al. 2023

J Biochem & Molecular Tox

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“…Regulates the switch between osteogenesis and adipogenesis by sponging miR-338-3p [57] circ-3626 Promotes osteogenesis by via miR-338-3p/Runx2 axis [7] Circ-FK501 Promotes osteogenic differentiation via microRNA-205-5p/RUNX2 axis [58] hsa-circ-0107593 Inhibits osteogenic differentiation via miR-20a-5p/SMAD6 signaling [59] Circ_0006873 Inhibits osteogenic differentiation via miR-20a-/SMURF2 signaling [60] Circ_0114581 Promotes osteogenic differentiation via the MiR-155-5p/HNRNPA3 axis [61] Circ_0001825 Promotes osteogenesis via miR-1270/SMAD5 axis [62] Circ_0036872 Promotes osteogenesis via miR-143-3p/IGF2 axis [63] CircZNF367 Inhibits osteogenic differentiation via reducing HuR-mediated mRNA stability of LRP5 [64] Circ_C4orf36 Promotes osteogenesis by regulating VEGFA [65] Circ-Sirt1 Promotes osteogenesis by activating Sirt1 and Wnt/β-catenin pathway [66] CircRNAs also play roles in maintaining bone homeostasis by regulating bone metabolism and the remodeling processes. For example, circRNA_ circ_0006859 was found to inhibit osteogenesis and promote adipogenesis in human in human bone marrow mesenchymal stem cells by targeting the signaling miR-431-5p/Rho-associated protein kinase 1 (ROCK1) [67] and circRNA-CDR1 promotes adipogenesis and inhibits osteogenic differentiation in osteonecrosis of the femoral head [68].…”

Section: Circ-dab1mentioning

confidence: 99%

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Valenti,

Zerlotin,

Cominacini

et al. 2024

Cells

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Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression with diverse roles in various biological processes. In recent years, research into circRNAs’ involvement in bone biology has gained significant attention, unveiling their potential as novel regulators and biomarkers in bone-related disorders and diseases. CircRNAs, characterized by their closed-loop structure, exhibit stability and resistance to degradation, underscoring their functional significance. In bone tissue, circRNAs are involved in critical processes such as osteogenic differentiation, osteoclastogenesis, and bone remodeling through intricate molecular mechanisms including microRNA regulation. Dysregulated circRNAs are associated with various bone disorders, suggesting their potential as diagnostic and prognostic biomarkers. The therapeutic targeting of these circRNAs holds promise for addressing bone-related conditions, offering new perspectives for precision medicine. Thus, circRNAs constitute integral components of bone regulatory networks, impacting both physiological bone homeostasis and pathological conditions. This review provides a comprehensive overview of circRNAs in bone biology, emphasizing their regulatory mechanisms, functional implications, and therapeutic potential.

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Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells

Gao,

Cheng,

et al. 2024

Open Life Sciences

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Delayed or failed bone healing is a significant clinical challenge worldwide. Bone marrow mesenchymal stem cells (BMSCs) offer a promising approach for improving fracture healing. Isomangiferin, a xanthone C-glucoside, is known for its pharmacological activities, but its role in fracture healing remains unclear. In this study, we investigated the effects of isomangiferin on BMSCs under oxidative stress conditions induced by hydrogen peroxide (H2O2). Our results showed that isomangiferin promotes osteogenic differentiation and migration of H2O2-treated BMSCs, reduces apoptosis and reactive oxygen species production, and activates the AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC) pathway. These findings suggest that isomangiferin may be a potential therapeutic agent for enhancing bone healing by modulating BMSC function.

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Circ_C4orf36 Promotes the Proliferation and Osteogenic Differentiation of BMSCs by Regulating VEGFA

Cited by 3 publications

References 40 publications

CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression

CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells

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