circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response

Zhou, Jie; Xu, Min; Chen, ZhaoZhao; Huang, LinLin; Wu, ZhuoLin; Huang, ZhongPei; Liu, Lin

doi:10.1007/s13770-023-00585-2

Search citation statements

Order By: Relevance

Paper Sections

Select...

Molecular Mechanisms That Regulate Bach21

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR regulation of BACH2 has been implicated in regulating the proportion of Tregs in diffuse large B-cell lymphoma [ 63 ].…”

Section: Molecular Mechanisms That Regulate Bach2mentioning

confidence: 99%

BACH2: The Future of Induced T-Regulatory Cell Therapies

Zwick,

Vo,

Shim

et al. 2024

Cells

View full text Add to dashboard Cite

BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of cell fate that is exquisitely sensitive to cell activation status. In particular, BACH2 plays a key role in stabilizing the phenotype and suppressive function of transforming growth factor-beta (TGF-β)-derived human forkhead box protein P3 (FOXP3)+ inducible regulatory T cells (iTregs), a cell type that holds great clinical potential as a cell therapeutic for diverse inflammatory conditions. As such, BACH2 potentially could be targeted to overcome the instability of the iTreg phenotype and suppressive function that has hampered their clinical application. In this review, we focus on the role of BACH2 in T cell fate and iTreg function and stability. We suggest approaches to modulate BACH2 function that may lead to more stable and efficacious Treg cell therapies.

show abstract

“…miR regulation of BACH2 has been implicated in regulating the proportion of Tregs in diffuse large B-cell lymphoma [ 63 ].…”

Section: Molecular Mechanisms That Regulate Bach2mentioning

confidence: 99%