Circadian and circannual rhythms of allergic rhinitis: An epidemiologic study involving chronobiologic methods

Reinberg, A; Gervais, Pierre; Lévi, Françis; Smolensky, Michael H.; Cerro, Luis Del; Ugolini, Catherine

doi:10.1016/0091-6749(88)90220-5

Cited by 108 publications

(61 citation statements)

References 9 publications

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“…Diurnal variation in cutaneous early phase responses after mast cell activation was reported for compound 48/80 in 1965 (20) and for allergen in 1977 (21). Both studies found increased wheal reactions in the late evening when serum cortisol levels are low.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that this phenomenon is related at least in part to the fall in cortisol levels seen at night (17,18), although efforts to demonstrate this conclusively have not been successful (19). Circadian variation in rhinitis and immediate cutaneous responses to antigen, 48/80, and histamine have also been described, but none have been linked directly to changes in endogenous cortisol (20)(21)(22). In man, IgE-dependent mast cell stimulation typically results in a biphasic clinical response.…”

Section: Introductionmentioning

confidence: 99%

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Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Herrscher

Kasper²,

Sullivan³

1992

J. Clin. Invest.

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To investigate the impact that physiological variation in serum cortisol has on IgE-mediated events, 10 atopic subjects underwent cutaneous antigen challenge with measurement of the early phase wheal (EPW) at 20 min and the late phase reaction (LPR) at 6 h. All subjects were challenged during control conditions between 8:00 and 9:00 a.m. Repeat challenges were performed in five subjects at 6:00 p.m. and in eight subjects after ingestion of metyrapone, a specific inhibitor of cortisol synthesis. Compared with control values, mean serum cortisol was suppressed in the evening and after metyrapone (P < 0.05 all time points). No effect was seen on the EPW, but mean LPR diameters at three antigen dilutions were significantly increased by cortisol suppression (P < 0.05). Replacement doses of hydrocortisone given in the evening and with metyrapone abrogated these increases. Blinded analysis of LPR biopsies from cortisol-suppressed subjects revealed increases in leukocytoclasis (P < 0.0001), interstitial leukocytes (P . 0.01), and eosinophils (P s 0.04). These results indicate that physiological levels of serum cortisol can regulate IgE-dependent cutaneous inflammation by affecting the expression of cellular events at late phase sites. (J. Clin. Invest. 1992. 90:596-603.)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Herrscher

Kasper²,

Sullivan³

1992

J. Clin. Invest.

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“…35 In addition, nasal congestion, rhinorrhea, and sneezing exhibit circadian rhythms, with the greatest intensity in early morning, thus exacerbating their negative effects on sleep. 36,37 Allergic rhinitis-related inflammatory mediators also exhibit a circadian pattern, with levels peaking in early morning. 38 In addition, sympathetic tone decreases at night, resulting in a relative parasympathetic excess, which is associated with nasal congestion and reduced bronchial dilation.…”

Section: Mechanisms Of Nasal Congestion: Impact On Sleep Quality and mentioning

confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion, rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing). The negative impact on sleep quality and quantity, and consequently on various aspects of the patient's life, is an under-recognised and under-treated component of AR morbidity. Nasal congestion, which is one of the most bothersome and prevalent symptoms of AR, is thought to be the leading symptom responsible for rhinitis-related sleep problems.In addition to reducing clinical symptoms, pharmacologic therapies for AR that specifically reduce inflammatory cells and mediators -and therefore nasal congestion and other symptoms -should also improve sleep quality and overall quality of life (QOL). Intranasal corticosteroids (INS) are the current mainstay of therapy for AR. Results of a number of clinical trials demonstrate that INS effectively reduce nasal congestion and ocular symptoms, improve sleep quality, and decrease daytime somnolence. Intranasal corticosteroids have also proved to be effective in reducing symptoms of acute rhinosinusitis and nasal polyposis, both of which also negatively impact on sleep quality. Intranasal corticosteroids are considered safe due to their low systemic bioavailability.

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“…Asthma shares a lot of characteristics with allergic diseases, including genetic risk factors (Bousquet et al 2000). Asthma episodes, as well as asthma exacerbations, are more prone to happen during the night and early morning compared to other times of the day both in adults and in children (Smolensky et al 2007;Reinberg et al 1988;Turner-Warwick 1988;Smolensky and D'Alonzo 1997;Hoskyns et al 1995;Jarjour 1999;Bohadana et al 2002;Litinski et al 2009). One of the first studies involving 3000 asthma patients found that asthma episodes during washout from regular maintenance asthma treatment occurred 70-fold more frequently between 4 am and 5 am compared to 2 pm-3 pm (Dethlefsen and Repges 1985).…”

Section: Asthmamentioning

confidence: 99%

“…Symptoms often intensify overnight and are worst upon wakening, displaying a "morning attack" (Smolensky et al 2007;Smolensky et al 2015;Long 2007;Gelfand 2004;Smolensky et al 1995;Reinberg et al 1988). Due to the time at which symptoms intensify, AR symptoms often disrupt sleep (Craig et al 2008;González-Núñez et al 2013;Santos et al 2006).…”

Section: Allergic Rhinitismentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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Circadian and circannual rhythms of allergic rhinitis: An epidemiologic study involving chronobiologic methods

Cited by 108 publications

References 9 publications

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

A circadian based inflammatory response – implications for respiratory disease and treatment

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