Circadian and Estrous Rhythms in Pineal Melatonin and 5-Hydroxy Indole-3-Acetic Acid.

Quay, W. B.

doi:10.3181/00379727-115-29014

Cited by 177 publications

(61 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The first and most well known is the pineal hormone melatonin. Its circadian oscillation was first discovered in 1964 (134), and it has been studied extensively as a marker of circadian rhythms ever since. Its antioxidant properties, however, were not discovered for almost another 30 years, when Ianas et al first published an article discussing the involvement of melatonin in the oxidative process (78).…”

Section: Oxidative Stress and Circadian Rhythms: Possible Links And Amentioning

confidence: 99%

“…Since it is difficult to directly measure the very short-lived ROS, much research has focused on studying the presence of the antioxidants and other enzymes produced by the body that work against the oxidant radicals (70). Interestingly, the cellular concentrations or activity levels of many of these antioxidants and protective small molecules (such as SOD, GPx, melatonin, and several others discussed in the next section) have been found to have circadian rhythmicity (37,107,134). This suggests an importance of both oxidative stress and the circadian rhythm in human diseases.…”

mentioning

confidence: 96%

See 1 more Smart Citation

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Wilking

Ndiaye²,

Mukhtar³

et al. 2013

Antioxidants & Redox Signaling

247

192

View full text Add to dashboard Cite

Significance: Oxygen and circadian rhythmicity are essential in a myriad of physiological processes to maintain homeostasis, from blood pressure and sleep/wake cycles, down to cellular signaling pathways that play critical roles in health and disease. If the human body or cells experience significant stress, their ability to regulate internal systems, including redox levels and circadian rhythms, may become impaired. At cellular as well as organismal levels, impairment in redox regulation and circadian rhythms may lead to a number of adverse effects, including the manifestation of a variety of diseases such as heart diseases, neurodegenerative conditions, and cancer. Recent Advances: Researchers have come to an understanding as to the basics of the circadian rhythm mechanism, as well as the importance of the numerous species of oxidative stress components. The effects of oxidative stress and dysregulated circadian rhythms have been a subject of intense investigations since they were first discovered, and recent investigations into the molecular mechanisms linking the two have started to elucidate the bases of their connection. Critical Issues: While much is known about the mechanics and importance of oxidative stress systems and circadian rhythms, the front where they interact has had very little research focused on it. This review discusses the idea that these two systems are together intricately involved in the healthy body, as well as in disease. Future Directions: We believe that for a more efficacious management of diseases that have both circadian rhythm and oxidative stress components in their pathogenesis, targeting both systems in tandem would be far more successful.

show abstract

Section: Oxidative Stress and Circadian Rhythms: Possible Links And Amentioning

confidence: 99%

mentioning

confidence: 96%

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Wilking

Ndiaye²,

Mukhtar³

et al. 2013

Antioxidants & Redox Signaling

247

192

View full text Add to dashboard Cite

show abstract

“…Serotonin levels in the rat pineal gland (Axelrod, 1974;Quay, 1963;Snyder , Zweig, Axelrod, & Fischer, 1965) and in the hypothalamus, frontal cortex, and brainstem (Quay, 1968) have cycles that are opposite in phase to the cycle of immobility duration in the present study. Pineal melatonin (Quay, 1964;Ralph, Mull, Lynch, & Hedlund, 1971), on the other hand, showed a circadian cycle that corresponds rather closely to the TI cycle in rats. As further support for this apparent relationship in a different species, Pang, Ralph, and Reilly (1974) show pineal melatonin cycles in chickens that are in the close agreement with cycles of TI durations reported by Piroch (1974) in that species.…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythms of tonic immobility in the rat: Evidence of an endogenous mechanism

Hennig

Dunlap

1977

Animal Learning & Behavior

View full text Add to dashboard Cite

“…It is eliminated from the body in the urine after its conversion from serotonin by monoamine oxidase (Cooper, Bloom, & Roth, 1978). Quay (1964) has measured circadian rhythms of 5-HIAA in rats, and a number of bioassay studies (e.g., Marsden & Curzon, 1976;Morgan & Rudeen, 1976;Morgan, Rudeen, & Pfeil, 1975) have used 5-HIAA as a measure of serotonin turnover, but little else is really known about its function. However, Morgan and Rudeen (1976) found an increase in brain 5-HlAA in rats after prolonged immobilization.…”

Section: Methodsmentioning

confidence: 99%

The effects of serotonin metabolites on tonic immobility in chickens (Gallus gallus): Dose and time response curves

et al. 1980

View full text Add to dashboard Cite

The effects of melatonin and 5-hydroxyindole acetic acid (5-HIAA) on tonic immobility in chickens were examined at various dosages and after several different postinjection time periods. Both of these metabolic byproducts of serotonin produced increases in duration of immobility at 10 min postinjection, but melatonin was much more potent than 5-HIAA. In addition, melatonin· produced a decrease in the duration of tonic immobility at 120 min postinjection, while 5-HIAA projuced a decrease at 60 min postinjection, which was followed by another increase in duration of immobility at 120 min. These results are discussed in terms of possible neurotransmitters and a central feedback system between brain levels of serotonin, its metabolites, and duration of tonic immobility.

show abstract

Circadian and Estrous Rhythms in Pineal Melatonin and 5-Hydroxy Indole-3-Acetic Acid.

Cited by 177 publications

References 0 publications

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Circadian rhythms of tonic immobility in the rat: Evidence of an endogenous mechanism

The effects of serotonin metabolites on tonic immobility in chickens (Gallus gallus): Dose and time response curves

Contact Info

Product

Resources

About