1998
DOI: 10.1210/jcem.83.6.4864
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Circadian and Ultradian Variations of Leptin in Normal Man under Continuous Enteral Nutrition: Relationship to Sleep and Body Temperature

Abstract: To determine the influence of circadian rhythmicity and sleep on the 24-h leptin diurnal variations, plasma leptin levels were measured at 10-min intervals over 24 h in seven normal subjects, once during nocturnal sleep, and once after an 8-h shift of sleep. The subjects were submitted to constant conditions (continuous enteral nutrition and bed rest in controlled chambers). Body temperature and plasma glucose and insulin levels were measured simultaneously. During nighttime sleep, leptin levels increased to a… Show more

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Cited by 176 publications
(97 citation statements)
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“…Under un-stressed and constant feeding conditions, leptin shows a marked nocturnal rise in humans [128]. When sleeping time is shifted by 8 h, leptin levels are differentially regulated by both the circadian system and sleep, resulting in a short period rhythm with peaks in the night and around mid-sleep phase [136]. In contrast, the diurnal expression of ghrelin seems not to be directly clock-regulated.…”
Section: Energy Metabolismmentioning
confidence: 99%
“…Under un-stressed and constant feeding conditions, leptin shows a marked nocturnal rise in humans [128]. When sleeping time is shifted by 8 h, leptin levels are differentially regulated by both the circadian system and sleep, resulting in a short period rhythm with peaks in the night and around mid-sleep phase [136]. In contrast, the diurnal expression of ghrelin seems not to be directly clock-regulated.…”
Section: Energy Metabolismmentioning
confidence: 99%
“…Indeed, it has been known for some time that the dorsomedial hypothalamus is involved in chemical signals related to food consumption and ingestive behaviour both of which represent hypothalamic functions linked with thermoregulation (Hamilton and Ciaccia 1971). For instance, leptin, a peptide involved in feeding behaviour, raises body temperature in mice and rats (Stehling et al 1997) and is implicated in the human behavioural, autonomic, and endocrine control of nycthemeral body temperature rhythm (Simon et al 1998). Administration of two other peptides, vasopressin and oxytocin, through intracerebroventricular injection induces grooming behaviour, characteristic of heat loss (Drago et al 1997).…”
Section: Thermosensors Involved In Behavioural Thermoregulatory Respomentioning
confidence: 99%
“…60 Aunado a esto aumenta la liberación de leptina por los adipocitos para evitar la sensación de hambre durante el sueño. 61 El eje HPA incrementa su actividad durante la última parte del sueño nocturno y prepara al orga-nismo para la actividad diaria. Así, el cortisol y las catecolaminas, que generalmente suprimen la función inmune, aumentan por la mañana, con lo cual se apaga la respuesta proinfl amatoria evocada durante la noche 62 (Figura 1).…”
Section: Sueño E Infl Amaciónunclassified