Circadian behavior of adult mice exposed to stress and fluoxetine during development

Kiryanova, Veronika; Smith, Victoria M.; Dyck, Richard H.; Antle, Michael C.

doi:10.1007/s00213-016-4515-3

Cited by 23 publications

(27 citation statements)

References 82 publications

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“…This specific pattern of increased time of resynchronization in the PRS animals is consistent with the increased stress corticosterone response and rhythm of secretion that has been reported in PRS animals and to a greater extent, in females (Koehl et al, 1997, 1999). Of note, significant increase in the number of days animals required in order to re-entrain to the new LD cycle following a phase shift, have been also observed in other prenatal stress paradigms in both mice and rats, following an 8-h advance/phase shift (chronic mild gestational stress, Kiryanova et al, 2017) or an abrupt 6-h delay/phase shift (prenatal hypoxia Joseph et al, 2002).…”

Section: Discussionmentioning

confidence: 68%

“…Indeed, androgen receptors are densely located in the core SCN and therefore act on the SCN via a direct pathway, unlike the estrogen receptors that are located mostly extra-SCN and act on SCN afferents (Mong et al, 2011). Nevertheless, the number of studies that associate reactive and predictive adaptations is limited, with the females being underrepresented (Zucker and Beery, 2010; Beery and Zucker, 2011; Kiryanova et al, 2017; McCarthy et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Perinatal Stress Programs Sex Differences in the Behavioral and Molecular Chronobiological Profile of Rats Maintained Under a 12-h Light-Dark Cycle

Morley‐Fletcher

Mairesse

Camp

et al. 2019

Front. Mol. Neurosci.

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Stress and the circadian systems play a major role in an organism’s adaptation to environmental changes. The adaptive value of the stress system is reactive while that of the circadian system is predictive. Dysfunctions in these two systems may account for many clinically relevant disorders. Despite the evidence that interindividual differences in stress sensitivity and in the functioning of the circadian system are related, there is limited integrated research on these topics. Moreover, sex differences in these systems are poorly investigated. We used the perinatal stress (PRS) rat model, a well-characterized model of maladaptive programming of reactive and predictive adaptation, to monitor the running wheel behavior in male and female adult PRS rats, under a normal light/dark cycle as well as in response to a chronobiological stressor (6-h phase advance/shift). We then analyzed across different time points the expression of genes involved in circadian clocks, stress response, signaling, and glucose metabolism regulation in the suprachiasmatic nucleus (SCN). In the unstressed control group, we found a sex-specific profile that was either enhanced or inverted by PRS. Also, PRS disrupted circadian wheel-running behavior by inducing a phase advance in the activity of males and hypoactivity in females and increased vulnerability to chronobiological stress in both sexes. We also observed oscillations of several genes in the SCN of the unstressed group in both sexes. PRS affected males to greater extent than females, with PRS males displaying a pattern similar to unstressed females. Altogether, our findings provide evidence for a specific profile of dysmasculinization induced by PRS at the behavioral and molecular level, thus advocating the necessity to include sex as a biological variable to study the set-up of circadian system in animal models.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Perinatal Stress Programs Sex Differences in the Behavioral and Molecular Chronobiological Profile of Rats Maintained Under a 12-h Light-Dark Cycle

Morley‐Fletcher

Mairesse

Camp

et al. 2019

Front. Mol. Neurosci.

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“…At 32 weeks, all animals received a subcutaneous injection of 5-HT 1A/7 receptor agonist 8-OH-DPAT (5 mg/kg, Sigma Aldrich Chemie BV, Zwijndrecht, the Netherlands) at a time point where low activity was measured in the DD (ZT 15) to trigger a phase-shifting response. Using the 6 days of the DD period prior to and the day including the 8-OH-DPAT injection, the free-running tau for activity and CBT before 8-OH-DPAT injection (pre-injection) was determined as has been done in a previous study (Kiryanova et al 2017 ). In addition, free-running tau for activity and CBT were calculated after 8-OH-DPAT injection (post-injection) using a period of 7 days excluding three transient—that is unstable—cycles after injection (Kiryanova et al 2017 ).…”

Section: Methodsmentioning

confidence: 99%

“…Using the 6 days of the DD period prior to and the day including the 8-OH-DPAT injection, the free-running tau for activity and CBT before 8-OH-DPAT injection (pre-injection) was determined as has been done in a previous study (Kiryanova et al 2017 ). In addition, free-running tau for activity and CBT were calculated after 8-OH-DPAT injection (post-injection) using a period of 7 days excluding three transient—that is unstable—cycles after injection (Kiryanova et al 2017 ). Subsequently, pre- and post-injection free-running tau were compared and the phase shift was calculated.…”

Section: Methodsmentioning

confidence: 99%

“…It is therefore assumed that SSRI exposure, e.g., during development, also affects circadian rhythms. Indeed, when male mice are exposed to FLX during the perinatal period, they show a shorter free-running period in total darkness, an increased phase shift to photic cues, and a decreased phase shift to nonphotic cues, suggesting persistent changes in the circadian system (Kiryanova et al 2013 , 2017 ). Despite behavioral alterations being observed, the mechanisms involved were not explored in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats

et al. 2020

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Rationale Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms. However, effects of perinatal SSRI treatment on circadian system functioning in the offspring are largely unknown. Objective Our aim was to investigate the effects of perinatal exposure to the SSRI fluoxetine (FLX) on circadian behavior, affective behavior, and 5-HT 1A receptor sensitivity in female rats. In addition, we studied the expression of clock genes and the 5-HT 1A receptor in the SCN, as they are potentially involved in underlying mechanisms contributing to changes in circadian rhythms. Results Perinatal FLX exposure shortened the free-running tau in response to the 5-HT 1A/7 agonist 8-OH-DPAT. However, FLX exposure did not alter anxiety, stress coping, and 5-HT 1A receptor sensitivity. No differences were found in 5-HT 1A receptor and clock genes Per1, Per2, Cry1, and Cry2 SCN gene expression. Conclusions Perinatal FLX exposure altered the response to a phase-shifting challenge in female rats, whether this may pose health risks remains to be investigated.

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Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Linhares

Meurer

Aquino

et al. 2022

Intl J of Devlp Neuroscience

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Serotonin (5-HT) reuptake inhibitors, such as fluoxetine, are the most prescribed antidepressant for maternal depression. In this sense, it exposes mothers and the brains of infants to increased modulatory and trophic effects of serotonergic neurotransmission. 5-HT promotes essential brain changes throughout its development, which include neuron migration, differentiation and organisation of neural circuitries related to emotional, cognitive and circadian behavior. Early exposure to the SSRIs induces long-term effects on behavioral and neural serotonergic signalisation. We have aimed to evaluate the circadian rhythm of locomotor activity and the neurochemical content, neuropeptide Y (NPY) and 5-HT in three brain areas: intergeniculate leaflet (IGL), suprachiasmatic nuclei (SCN) and raphe nuclei (RN), at two zeitgebers (ZT6 and ZT18), in male and female rat's offspring early exposed (developmental period GD13-GD21) to fluoxetine (20 mg/kg). First, we have conducted daily records of the locomotor activity rhythm using activity sensors coupled to individual cages over 4 weeks. We have lastly evaluated the immunoreactivity of NPY in both SCN and IGL, as well the 5-HT expression in the dorsal and medial RN. In summary, our results showed that (1) prenatal fluoxetine affects phase entrainment of the rest/activity rhythm at ZT6 and ZT18, more in male than female specimens, and (2) modulates the NPY and 5-HT expression. Here, we show male rats are more susceptible to phase entrainment and the NPY and 5-HT misexpression compared to female ones. The sex differences induced by early exposure to fluoxetine in both the circadian rhythm of locomotor activity and the neurochemical expression into SCN, IGL and midbrain

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Circadian behavior of adult mice exposed to stress and fluoxetine during development

Abstract: Our results suggest that, in mice, perinatal exposure to either FLX, or PS, or their combination, leads to discernible, persistent changes in their circadian systems as adults.

Cited by 23 publications

References 82 publications

Perinatal Stress Programs Sex Differences in the Behavioral and Molecular Chronobiological Profile of Rats Maintained Under a 12-h Light-Dark Cycle

Perinatal Stress Programs Sex Differences in the Behavioral and Molecular Chronobiological Profile of Rats Maintained Under a 12-h Light-Dark Cycle

Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats

Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

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