Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

Cretenet, Gaspard; Clech, Mikaël Le; Gachon, Frédéric

doi:10.1016/j.cmet.2009.11.002

Cited by 165 publications

(196 citation statements)

References 76 publications

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“…These are supported by the studies showing that Clock mutant and Bmal1 -null mice develop hyperlipidemia and hepatic steatosis ( 19,28 ) and that ablation of Rev-erbs and histone deacetylase 3 ( Hdac3 ), both of which control the circadian expression of lipogenic genes, increases TG content in the liver ( 29,30 ). In addition, Per1/Per2 -null mice showed reduced liver TG levels ( 31 ), and hepatic TG concentrations were elevated in Cry1/Cry2 -null mice ( 32 ).…”

Section: Mrna Analysissupporting

confidence: 56%

KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression

Chou

Zhu

Lin

et al. 2015

Journal of Lipid Research

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Section: Mrna Analysissupporting

confidence: 56%

KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression

Chou

Zhu

Lin

et al. 2015

Journal of Lipid Research

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“…Finally, the increase in expression of Elovl6 is well beyond the increase in expression that is normally seen during this time frame in the light phase (a twofold increase that is normally seen compared with a 47 . 2-fold increase observed in this study) (Cretenet et al 2010). It seems, therefore, unlikely that the differences observed in the expression of metabolic genes, which is the focus of this study, are primarily due to the differences in feeding and sectioning time.…”

Section: Induction Of Mitophagymentioning

confidence: 67%

Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health

Duivenvoorde¹,

Schothorst²,

Bunschoten³

et al. 2011

Journal of Molecular Endocrinology

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High energy intake and, specifically, high dietary fat intake challenge the mammalian metabolism and correlate with many metabolic disorders such as obesity and diabetes. However, dietary restriction (DR) is known to prevent the development of metabolic disorders. The current western diets are highly enriched in fat, and it is as yet unclear whether DR on a certain high-fat (HF) diet elicits similar beneficial effects on health. In this research, we report that HF-DR improves metabolic health of mice compared with mice receiving the same diet on an ad libitum basis (HF-AL). Already after five weeks of restriction, the serum levels of cholesterol and leptin were significantly decreased in HF-DR mice, whereas their glucose sensitivity and serum adiponectin levels were increased. The body weight and measured serum parameters remained stable in the following 7 weeks of restriction, implying metabolic adaptation. To understand the molecular events associated with this adaptation, we analyzed gene expression in white adipose tissue (WAT) with whole genome microarrays. HF-DR strongly influenced gene expression in WAT; in total, 8643 genes were differentially expressed between both groups of mice, with a major role for genes involved in lipid metabolism and mitochondrial functioning. This was confirmed by quantitative real-time reverse transcription-PCR and substantiated by increase in mitochondrial density in WAT of HF-DR mice. These results provide new insights in the metabolic flexibility of dietary restricted animals and suggest the development of substrate efficiency.

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“…3G) that morphed onto 24 h rhythms in the KO. It was previously described that 12-h-period genes changed to 24-h period in circadian clock-deficient mice (26,27). It is likely that the two peaks of the 12-h rhythm are regulated by the circadian clock and feeding rhythms, respectively, and that the circadian component disappeared in the KO (27).…”

Section: Resultsmentioning

confidence: 99%

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

Atger

Gobet

Marquis

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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215

287

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Diurnal oscillations of gene expression are a hallmark of rhythmic physiology across most living organisms. Such oscillations are controlled by the interplay between the circadian clock and feeding rhythms. Although rhythmic mRNA accumulation has been extensively studied, comparatively less is known about their transcription and translation. Here, we quantified simultaneously temporal transcription, accumulation, and translation of mouse liver mRNAs under physiological light-dark conditions and ad libitum or night-restricted feeding in WT and brain and muscle Arnt-like 1 (Bmal1)-deficient animals. We found that rhythmic transcription predominantly drives rhythmic mRNA accumulation and translation for a majority of genes. Comparison of wild-type and Bmal1 KO mice shows that circadian clock and feeding rhythms have broad impact on rhythmic gene expression, Bmal1 deletion affecting surprisingly both transcriptional and posttranscriptional levels. Translation efficiency is differentially regulated during the diurnal cycle for genes with 5′-Terminal Oligo Pyrimidine tract (5′-TOP) sequences and for genes involved in mitochondrial activity, many harboring a Translation Initiator of Short 5′-UTR (TISU) motif. The increased translation efficiency of 5′-TOP and TISU genes is mainly driven by feeding rhythms but Bmal1 deletion also affects amplitude and phase of translation, including TISU genes. Together this study emphasizes the complex interconnections between circadian and feeding rhythms at several steps ultimately determining rhythmic gene expression and translation.circadian rhythms | ribosome profiling | mRNA translation | 5′-TOP sequences | TISU motifs L iving organisms on Earth are subjected to light-dark cycles caused by rotation of the Earth around the sun. To anticipate these changes, virtually all organisms have acquired a circadian timing system during evolution that allows a better adaptation to their environment. As a consequence, most aspects of their physiology are orchestrated in a rhythmic way by the circadian clock (from the Latin circa diem, meaning "about a day"), an endogenous and autonomous oscillator with a period of around 24 h (1, 2). Not surprisingly, perturbations of this clock in mammals lead to pathologies including psychiatric, metabolic, and vascular disorders (1,3,4). At the organismal scale, the oscillatory clockwork is organized in a hierarchal manner. Within the suprachiasmatic nuclei (SCN) of the hypothalamus, the "master clock" receives light input via the retina and communicates timing signals to "enslave" oscillators in peripheral organs (1, 2). The molecular oscillator consists of interconnected transcriptional and translational feedback loops, in which multiple layers of control, including temporal posttranscriptional and posttranslational regulation, play important roles (5). These additional layers of regulation are largely coordinated by systemic cues originating from circadian clock and/or feeding-coordinated rhythmic metabolism, allowing the adjustment of the molecular clo...

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Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

Cited by 165 publications

References 76 publications

KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression

KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression

Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health

Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver

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