Circadian Clock Proteins in Prokaryotes: Hidden Rhythms?

Loza-Correa, Maria; Gómez-Valero, Laura; Buchrieser, Carmen

doi:10.3389/fmicb.2010.00130

Cited by 37 publications

(35 citation statements)

References 63 publications

(116 reference statements)

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“…We previously proposed that the timekeeping system in R. palustris is a ‘proto-circadian’ oscillator that does not persist under constant conditions 14 . This hypothesis is consistent with the observation that P. marinus — which ‘lost’ kaiA 77–79 — also does not sustain robust rhythms of gene expression or KaiC phosphorylation under constant conditions 79–82 (FIG. 4).…”

Section: The Sun Also Rises For Other Bacteriasupporting

confidence: 90%

“…Homologues of kaiB and kaiC are distributed widely among both photosynthetic and non-photosynthetic members of the Eubacteria and the Archaea, but kaiA is found only in cyanobacteria 77,78 . Even among cyanobacteria, the kaiA gene was lost during evolution in the important cyanobacterial genus Prochlorococcus , which retained kaiB and kaiC and has daily rhythms, but not a sustained circadian rhythm, under constant conditions 79,80 .…”

Section: The Sun Also Rises For Other Bacteriamentioning

confidence: 99%

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Timing the day: what makes bacterial clocks tick?

et al. 2017

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Chronobiological studies of prokaryotic organisms have generally lagged far behind the study of endogenous circadian clocks in eukaryotes, in which such systems are essentially ubiquitous. However, despite only being studied during the past 25 years, cyanobacteria have become important model organisms for the study of circadian rhythms and, presently, their timekeeping mechanism is the best understood of any system in terms of biochemistry structural biology, biophysics and adaptive importance. Nevertheless, intrinsic daily rhythmicity among bacteria other than cyanobacteria is essentially unknown; some tantalizing information suggests widespread daily timekeeping among Eubacteria and Archaea through mechanisms that share common elements with the cyanobacterial clock but are distinct. Moreover, the recent surge of information about microbiome–host interactions has largely neglected the temporal dimension and yet daily cycles control important aspects of their relationship.

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Section: The Sun Also Rises For Other Bacteriasupporting

confidence: 90%

Section: The Sun Also Rises For Other Bacteriamentioning

confidence: 99%

Timing the day: what makes bacterial clocks tick?

et al. 2017

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“…While kaiA appears to be specific to cyanobacterial genomes, potential homologs of kaiB and kaiC are widespread in species of Archaea and, to a lesser extent, in genomes of Proteobacteria, Chloroflexi, and Bacteroides (90,95). Both kaiB and kaiC genes are found in some genomes, while only orthologs of kaiC can be identified in others.…”

Section: Kai Proteins Outside Cyanobacteriamentioning

confidence: 98%

Circadian Rhythms in Cyanobacteria

Cohen

Golden

2015

Microbiol Mol Biol Rev

242

224

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SUMMARYLife on earth is subject to daily and predictable fluctuations in light intensity, temperature, and humidity created by rotation of the earth. Circadian rhythms, generated by a circadian clock, control temporal programs of cellular physiology to facilitate adaptation to daily environmental changes. Circadian rhythms are nearly ubiquitous and are found in both prokaryotic and eukaryotic organisms. Here we introduce the molecular mechanism of the circadian clock in the model cyanobacteriumSynechococcus elongatusPCC 7942. We review the current understanding of the cyanobacterial clock, emphasizing recent work that has generated a more comprehensive understanding of how the circadian oscillator becomes synchronized with the external environment and how information from the oscillator is transmitted to generate rhythms of biological activity. These results have changed how we think about the clock, shifting away from a linear model to one in which the clock is viewed as an interactive network of multifunctional components that are integrated into the context of the cell in order to pace and reset the oscillator. We conclude with a discussion of how this basic timekeeping mechanism differs in other cyanobacterial species and how information gleaned from work in cyanobacteria can be translated to understanding rhythmic phenomena in other prokaryotic systems.

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“…They are also well-conserved through divergent phylogenetic lineages (Supporting Information Fig. S1A) (Loza-Correa et al, 2010). Among 17 genome-sequenced Methylobacterium strains, all strains except Methylobacterium nodulans ORS2060 were found to possess multiple KaiCs with different phylogenies (Supporting Information Table S1).…”

Section: Resultsmentioning

confidence: 99%

KaiC family proteins integratively control temperature‐dependent UV resistance in Methylobacterium extorquens AM1

Iguchi

Yoshida

Fujisawa

et al. 2018

Environ Microbiol Rep

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KaiC protein is the pivotal component of the circadian clock in cyanobacteria. While KaiC family proteins are well-conserved throughout divergent phylogenetic lineages, studies of the physiological roles of KaiC proteins from other microorganisms have been limited. We examined the role of the KaiC proteins, KaiC1 and KaiC2, in the methanol-utilizing bacterium Methylobacterium extorquens AM1. Wild-type M. extorquens AM1 cells exhibited temperature-dependent UV resistance (TDR) under permissive growth temperatures (24 °C -32 °C). Both the phosphorylation of KaiC2 and the intracellular levels of KaiC1 were temperature-dependent, and the TDR phenotype was positively regulated by KaiC1 and negatively regulated by KaiC2. Taken together with biochemical and functional analogies to the KaiC protein of cyanobacteria, our present results suggest that KaiC family proteins function to integrate environmental cues, that is, temperature and UV light, and output appropriate cellular responses to allow cells to adapt to changing environmental conditions.© 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

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Circadian Clock Proteins in Prokaryotes: Hidden Rhythms?

Cited by 37 publications

References 63 publications

Timing the day: what makes bacterial clocks tick?

Timing the day: what makes bacterial clocks tick?

Circadian Rhythms in Cyanobacteria

KaiC family proteins integratively control temperature‐dependent UV resistance in Methylobacterium extorquens AM1

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