Circadian control of pain and neuroinflammation

Segal, Julia P.; Tresidder, Kaitlyn A.; Bhatt, Charvi; Gilron, Ian; Ghasemlou, Nader

doi:10.1002/jnr.24150

Cited by 69 publications

(53 citation statements)

References 240 publications

(327 reference statements)

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“…Sleep changes and loss of circadian rhythm is common in those with chronic pain (Alföldi, Wiklund and Gerdle, 2014), and myriad chronic diseases, including chronic pain, have shown diurnal patterns in symptom severity, intensity and mortality (Smolensky et al, 2015;Segal et al, 2018). Chronic pain is also a common component of many neurological diseases, particularly Parkinson's disease (Borsook, 2012), and disorders such as Multiple Sclerosis and migraines are considered neurological in nature.…”

Section: Genetic Correlationsmentioning

confidence: 99%

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Johnston

Adams

Nicholl

et al. 2018

Preprint

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Chronic pain is highly prevalent worldwide, contributing a significant socioeconomic and public health burden. Several aspects of chronic pain, for example back pain and a severity-related phenotype, chronic pain grade, have been shown to be complex, heritable traits with a polygenic component. Additional pain-related phenotypes capturing aspects of an individual's overall sensitivity to experiencing and reporting chronic pain have also been suggested. We have here made use of a measure of the number of sites of chronic pain in individuals within the general UK population. This measure, termed Multisite Chronic Pain (MCP), is also a complex trait, but its genetic architecture has not previously been investigated. To address this, a large-scale genome-wide association study (GWAS) of MCP was carried out in ~380,000 UK Biobank participants to identify associated genetic variants. Findings were consistent with MCP having a significant polygenic component with a SNP heritability of 10.2%, and 76 independent lead single nucleotide polymorphisms (SNPs) at 39 risk loci were identified. Additional gene-level association analyses identified neurogenesis, synaptic plasticity, nervous system development, cell-cycle progression and apoptosis genes as being enriched for genetic association with MCP. Genetic correlations were observed between MCP and a range of psychiatric, autoimmune and anthropometric traits including major depressive disorder (MDD), asthma and BMI. Furthermore, in Mendelian randomisation (MR) analyses a bi-directional causal relationship was observed between MCP and MDD. A polygenic risk score (PRS) for MCP was found to significantly predict chronic widespread pain (pain all over the body), indicating the existence of genetic variants contributing to both of these pain phenotypes. These findings support the proposition that chronic pain involves a strong nervous system component and have implications for our understanding of the physiology of chronic pain and for the development of novel treatment strategies.

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Section: Genetic Correlationsmentioning

confidence: 99%

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Johnston

Adams

Nicholl

et al. 2018

Preprint

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“…It is important to highlight the dynamic influence that sensory perception may present in the contexts of the internal or external environments. High levels of glycated haemoglobin have been associated with facial hypoalgesia in patients with diabetes mellitus [28], and there is an influence of the circadian cycle on sensory perception, depending on hormones and mediators [29,30].…”

Section: The Dynamic Process Of Sensory Perception In the Craniofaciamentioning

confidence: 99%

Sensory interaction theory: revision of the craniofacial region

Siqueira¹,

Teixeira²

2019

ppn

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Purpose: The objective of this study was to review the literature to find scientific evidence about the mechanisms involved in orofacial sensory interaction, including trigeminal and special sensory modalities. Views: Conscious sensory perception depends on peripheral external and internal stimuli, which are integrated and processed in central neural centres in order to promote the sensory experience through learning and memory. In the orofacial region, besides somatosensory inputs, there are special sensory modalities (gustation, olfaction, vision and audition) that interact with trigeminal ascendant inputs in a way that makes this area of the body unique. Moreover, the trigeminal nerve may have an important role due to the complex functions of this region, including breathing, feeding and detecting threats. In recent decades the development of equipment accurate enough to detect sensory thresholds has produced a wide range of evidence about orofacial interaction, which allows for the possible development of a unified underlying theory on this issue. Conclusions: The trigeminal system seems to mediate olfactory and gustative sensations in cortical associative centres, and sensory peripheral neural inputs are modulated by physiological and pathological conditions. Future experimental studies should seek to clarify the mechanisms involved in this interaction, and the role of pathological states in abnormalities of sensory thresholds and perception.

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“…They are thought to have similar functions to astrocytes in the central nervous system (CNS). The involvement of glia in chronic pain has been studied extensively over the past three decades (Costa & Moreira Neto, ; Gosselin, Suter, Ji, & Decosterd, ; Segal, Tresidder, Bhatt, Gilron, & Ghasemlou, ). The increasing amount of evidence suggests that SGCs are activated in the sensory ganglia and implicated in pain processing.…”

Section: Introductionmentioning

confidence: 99%

The role of satellite glial cells in orofacial pain

Fan

Zhu

et al. 2018

J of Neuroscience Research

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Some chronic pain conditions in the orofacial region are common, the mechanisms underlying which are unresolved. Satellite glial cells (SGCs) are the glial cells of the peripheral nervous system. In the sensory ganglia, each neuronal body is surrounded by SGCs forming distinct functional units. The unique structural organization enables SGCs to communicate with each other and with their enwrapped neurons via a variety of ways. There is a growing body of evidence that SGCs can influence the level of neuronal excitability and are involved in the development and/or maintenance of pain. The aim of this review was to summarize the latest advances made about the implication of SGCs in orofacial pain. It may offer new targets for the development of orofacial pain treatment.

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Circadian control of pain and neuroinflammation

Cited by 69 publications

References 240 publications

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Genome-wide Association Study of Multisite Chronic Pain in UK Biobank

Sensory interaction theory: revision of the craniofacial region

The role of satellite glial cells in orofacial pain

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