2024
DOI: 10.1002/bies.202300158
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Circadian Control of Protein Synthesis

Nathan R. James,
John S. O'Neill

Abstract: Daily rhythms in the rate and specificity of protein synthesis occur in most mammalian cells through an interaction between cell‐autonomous circadian regulation and daily cycles of systemic cues. However, the overall protein content of a typical cell changes little over 24 h. For most proteins, translation appears to be coordinated with protein degradation, producing phases of proteomic renewal that maximize energy efficiency while broadly maintaining proteostasis across the solar cycle. We propose that a majo… Show more

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