Circadian disruption and sleep disorders in neurodegeneration

Shen, Yun; Lv, Qian-kun; Xie, Wei-ye; Gong, Siyi; Zhuang, Sheng; Liu, Junyi; Mao, Cheng‐Jie; Liu, Chun‐Feng

doi:10.1186/s40035-023-00340-6

Cited by 47 publications

(21 citation statements)

References 312 publications

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“…186,187 Furthermore, this appears bidirectional, while circadian and sleep disorders worsen neurodegeneration, neurodegenerative diseases can disrupt circadian rhythms and sleep. 188 This interplay between circadian rhythms and neurodegeneration raises the question of whether neurodegeneration causes circadian rhythm disruption, or whether circadian rhythm disruption causes or accelerates neurodegeneration.…”

Section: Open Questions and Future Directions What Are The Molecular ...mentioning

confidence: 99%

Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Kim,

Keep,

Zhang

2024

Circulation Research

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The blood-brain barrier (BBB) is a critical interface separating the central nervous system from the peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled a profound connection between the BBB and circadian rhythms, the endogenous oscillations synchronizing biological processes with the 24-hour light-dark cycle. This review explores the significance of circadian rhythms in the context of BBB functions, with an emphasis on substrate passage through the BBB. Our discussion includes efflux transporters and the molecular timing mechanisms that regulate their activities. A significant focus of this review is the potential implications of chronotherapy, leveraging our knowledge of circadian rhythms for improving drug delivery to the brain. Understanding the temporal changes in BBB can lead to optimized timing of drug administration, to enhance therapeutic efficacy for neurological disorders while reducing side effects. By elucidating the interplay between circadian rhythms and drug transport across the BBB, this review offers insights into innovative therapeutic interventions.

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Section: Open Questions and Future Directions What Are The Molecular ...mentioning

confidence: 99%

Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Kim,

Keep,

Zhang

2024

Circulation Research

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“…These disruptions are not only considered manifestations of the diseases but may also directly contribute to their pathogenesis [ 122 ]. The role of circadian rhythm abnormalities in these disorders has become increasingly recognized, with evidence suggesting that circadian rhythm disruption and sleep disorders aggravate neurodegeneration; correspondingly, neurodegenerative diseases can disrupt circadian rhythms and sleep [ 123 ].…”

Section: Circadian Disruption In Pdmentioning

confidence: 99%

Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease

Chen,

Wang,

Lewis

et al. 2024

JMD

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Circadian disruption is being increasingly recognized as a critical factor in the development and progression of Parkinson’s disease (PD). This review aims to provide an in-depth overview of the relationship between circadian disruption and PD by exploring the molecular, cellular, and behavioral aspects of this interaction. This review will include a comprehensive understanding of how the clock gene system and transcription–translation feedback loops function and how they are diminished in PD. The article also discusses the role of clock genes in the regulation of circadian rhythms, as well as the impact of clock gene dysregulation on mitochondrial function, oxidative stress, and neuroinflammation, including the microbiota-gut-brain axis, which have all been proposed as being crucial mechanisms in the pathophysiology of PD. Finally, this review highlights potential therapeutic strategies targeting the clock gene system and circadian rhythm for the treatment of PD.

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“…Sleep disorders are very common in the setting of PD, with a prevalence of close to 90% [ 124 ]. PD patients exhibit various forms of sleep disorders, such as insomnia, daytime sleepiness, circadian rhythm disorder, and rapid eye movement (REM) sleep behavior disorder (RBD) [ 125 ]. Idiopathic RBD (iRBD) is the most dependable hallmark of prodromal PD and the likelihood ratio of iRBD developing into PD is greater than that for the general population [ 126 , 127 ].…”

Section: Scfas and Non-motor Symptoms Of Pdmentioning

confidence: 99%

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic

Duan,

Wang,

Liu

et al. 2023

Neurosci. Bull.

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Parkinson’s disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, and massive loss of midbrain dopamine neurons. Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the development of PD. Among these, short-chain fatty acids (SCFAs), the most abundant microbial metabolites, have been proven to play a key role in brain-gut communication. In this review, we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor symptoms. Future research should focus on further elucidating the role of SCFAs in neuroinflammation, as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

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Circadian disruption and sleep disorders in neurodegeneration

Cited by 47 publications

References 312 publications

Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Fighting Against the Clock: Circadian Disruption and Parkinson’s Disease

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic

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