Circadian disruption in the pathogenesis of metabolic syndrome

Maury, Eléonore; Hong, Hee-Kyung; Bass, Joseph

doi:10.1016/j.diabet.2013.12.005

Cited by 109 publications

(80 citation statements)

References 120 publications

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“…The same can be observed in the other adipocytokines like adiponectine and resistin too, which are linked to accentuated obesity, T2DM and metabolic syndrome [35]. The neuroendocrine system in the hypothalamus senses nutrients (glucose and lipids) and through a complex, in part feedback-type, pathway detects and then regulates circulating metabolic hormones such as leptin, insulin, thyroid hormones, adiponectin and ghrelin, which exhibit circadian oscillation [30,33,36,37]. As a result, diurnal variation in glucose, glucose tolerance [38] insulin, triglycerides and adipose-derived hormones becomes apparent [39].…”

Section: Background Studiesmentioning

confidence: 73%

“…Circadian rhythms do regulate metabolism and energy homeostasis to a certain extent. Circadian disruption and shortness of sleep have an important impact to the development of the metabolic syndrome [30]. A cluster of related risk factors (e.g., dyslipidemia, hypertension, hyperglycemia) make this syndrome risky for cardiovascular disorders and resistance to insulin eventually leading to type 2 diabetes mellitus (T2DM) [31].…”

Section: Background Studiesmentioning

confidence: 99%

“…Lipid metabolism shows a strong dependence of the circadian rhythm, which controls lipolysis rate, release of free fatty acids, triglyceride and hormone-sensitive lipase activity [26][27][28][29][30][31] and intestinal lipid absorption [32,33]. 3.…”

Section: Background Studiesmentioning

confidence: 99%

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Chronobiology and circadian rhythms establish a connection to diagnosis

Nydegger

Escobar

Risch³

et al. 2014

Diagnosis

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Circadian rhythms are synchronized by the light/dark (L/D) cycle over the 24-h day. A suprachiasmatic nucleus in the hypothalamus governs time keeping based on melanopsin messages from the retina in the eyes and transduces regulatory signals to tissues through an array of hormonal, metabolic and neural outputs. Currently, vague impressions on circadian regulation in health and disease are replaced by scientific facts: in addition to L/D cyling, oscillation is maintained by genetic (Clock, Bmal1, Csnk1, CHRONO, Cry, Per) programs, autonomous feedback loops, including melatonin activities, aerobic glycolysis intensity and lipid signalling, among others. Such a multifaceted influential system on circadian rhythm is bound to be fragile and genomic clock acitvities can become disrupted by epigenetic modifications or such environmental factors as mistimed sleep and feeding schedules albeit leaving the centrally driven melatonindependent pacemakter more or less unaffected.

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Section: Background Studiesmentioning

confidence: 73%

Section: Background Studiesmentioning

confidence: 99%

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Chronobiology and circadian rhythms establish a connection to diagnosis

Nydegger

Escobar

Risch³

et al. 2014

Diagnosis

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“…Thus, the reduction in total sleep duration is associated with decreased serum leptin levels and increased circulating ghrelin increases hunger and food intake. (7,13,14) The studied industry had a cafeteria, however, workers complained about the quality of the served food and many chose to bring their own lunch box, frozen foods, savory or sweet. Workers from the first and third shifts reported that they often drank coffee to stay "awake", and it was always accompanied by treats.…”

Section: Discussionmentioning

confidence: 99%

Prevalência de síndrome metabólica em metalúrgicos de diferentes turnos de trabalho

2015

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“…This arises as consequence of a mutation occurring in C57BL/6J mice and abolishing the expression of Arylalkylamine N-acetyltransferase a key enzyme in the Melatonin synthesis [25]. Since Melatonin has been already involved in energy expenditure and body weight regulation, we thought it could have been interesting to verify if Melatonin was contributing to the different response of the two strains [26][27][28].…”

Section: The Absence Of Melatonin Contributes To Explain the Differenmentioning

confidence: 99%

A Crosstalk between Melatonin and Taste-Receptors’ Signaling Tunes Quinine-Induced Gut Hormone Secretion in Mice

Tenore¹,

Bottone²,

Riccio³

et al. 2018

J Nutr Food Sci

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Quinine consumption has been shown to reduce appetite and food intake in human and mice. Here, tested on two common mouse strains, C 3 H/lbg and C57BL/6J, it exerted a different effect. While quinine reduced weight gain in C 3 H/lbg mice, C57BL/6J were unaffected by the bitter molecule. Among the differences between the two strains, C57BL/6J present a blunted Melatonin production. In this study, we investigate if endogenous Melatonin is playing any role in the different response of C57BL/6J mice to quinine. The effect of dietary supplementation with Melatonin as well as of endogenous gastrointestinal and pineal produced Melatonin was investigated by supplementing quinine diet with pure Melatonin, L-Tryptophan or by reversion of light/dark cycle, respectively. The consumption of Melatonin reverts the phenotype and makes C57BL/6J mice sensitive to quinine. Similarly, quinine potency in C 3 H/ Ibg mice augments upon supplementation with exogenous Melatonin or upon increase of Melatonin endogenous levels. In vivo, as well as in in vitro cell cultures, Melatonin Receptor modulation inhibits quinine dependent secretion of Ghrelin, while potentiates quinine dependent secretion of Cholecystokinin. Acting via Melatonin Receptors, Melatonin tunes the effect of quinine, reducing and potentiating its effect in enteroendocrine cells of the upper and the lower digestive tract, respectively. Our results indicate that signaling pathways activated by Melatonin tunes the activity of Bitter Receptors located in the gastrointestinal tract.

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Circadian disruption in the pathogenesis of metabolic syndrome

Cited by 109 publications

References 120 publications

Chronobiology and circadian rhythms establish a connection to diagnosis

Chronobiology and circadian rhythms establish a connection to diagnosis

Prevalência de síndrome metabólica em metalúrgicos de diferentes turnos de trabalho

A Crosstalk between Melatonin and Taste-Receptors’ Signaling Tunes Quinine-Induced Gut Hormone Secretion in Mice

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