Circadian disruption of memory consolidation in Drosophila

Yin, Jingyi; Cui, Ethan; Hardin, Paul E.; Zhou, Hong

doi:10.3389/fnsys.2023.1129152

Cited by 3 publications

(3 citation statements)

References 94 publications

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“…per expression is essential for establishing 1 d memory induced by aversive olfactory learning [26]. Furthermore, as was observed in courtship LTM, Yin et al reported that light is required for the maintenance of LTM induced by aversive olfactory learning and that a clock gene other than per, vrill is also required for the consolidation of LTM induced by aversive olfactory learning [39]. These findings imply that clock genes and clock neurons play an important role in the regulation of Drosophila LTM, regardless of the learning method.…”

Section: Possible Model Of the Regulation Of Ltm Maintenance Via Lndsmentioning

confidence: 88%

Regulation of long-term memory by a few clock neurons in <i>Drosophila</i>

Shirakawa,

Kurata,

Sakai

2024

BIOPHYSICS

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Identification of the neural circuits in the brain regulating animal behavior and physiology is critical for understanding brain functions and is one of the most challenging goals in neuroscience research. The fruitfly Drosophila melanogaster has often been used to identify the neural circuits involved in the regulation of specific behaviors because of the many neurogenetic tools available to express target genes in particular neurons. Neurons controlling sexual behavior, feeding behavior, and circadian rhythms have been identified, and the number of neurons responsible for controlling these phenomena is small. The search for a few neurons controlling a specific behavior is an important first step to clarify the overall picture of the neural circuits regulating that behavior. We previously found that the clock gene period (per), which is essential for circadian rhythms in Drosophila, is also essential for long-term memory (LTM). We have also found that a very limited number of per-expressing clock neurons in the adult brain are required for the consolidation and maintenance of LTM. In this review, we focus on LTM in Drosophila, introduce the concept of LTM regulation by a few clock neurons that we have recently discovered, and discuss how a few clock neurons regulate Drosophila LTM.

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Section: Possible Model Of the Regulation Of Ltm Maintenance Via Lndsmentioning

confidence: 88%

Regulation of long-term memory by a few clock neurons in <i>Drosophila</i>

Shirakawa,

Kurata,

Sakai

2024

BIOPHYSICS

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“…performance by recruiting neuromodulatory pathways to optimize information processing in the brain. In flies, clock circuits play an active role in memory formation, regulate sleep and waking, and impose daily activity rhythms onto dopaminergic neurons ( 32–37 ). Thus, here we examine the intricate interplay between sleep, clock circuits, and dopaminergic modulatory pathways in shaping memory formation in flies suffering catastrophic brain damage.…”

Section: Introductionmentioning

confidence: 99%

Breaking free from the clock’s tyranny restores memory to brain damaged flies

Dissel,

Morgan,

Cao

et al. 2024

Preprint

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The relationship between sleep and memory is an active topic of investigation. In this context, we demonstrate that enhancing sleep restores memory to flies with ablated Mushroom Bodies (MB), a key memory center; this is consistent across several memory assays. Mapping the underlying circuitry reveals circadian modulation of a subset of Dopaminergic neurons (DANs) that modulate aversive learning. Using imaging, we show that MB-ablation disrupts, and sleep restores the time of day these neurons are most responsive. Knocking down the receptor for the clock output signal, Pigment-dispersing factor (Pdfr), in this subset of DANs restores memory to MB-ablated flies. Crucially, MB-ablation does not result in memory impairments in the absence of a functioning clock. Our results reveal neuromodulation's key role in cognitive restoration, where sleep aids memory in damaged brains, but a functioning clock unexpectedly hinders this process.

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“…These findings are consistent with the behavioral criteria for sleep in mammals. As a result, research in D. melanogaster has shown not only that sleep facilitates learning in wild-type and memory-impaired flies, but also that sleep deprivation impairs the acquisition and consolidation of new memories [14,15].…”

Section: Introductionmentioning

confidence: 99%

Sleep-like State in Pond Snails Leads to Enhanced Memory Formation

Namiki,

Nakai,

Lukowiak

et al. 2024

Biology

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To test the hypothesis that a sleep-like quiescent state enhances memory consolidation in the pond snail Lymnaea stagnalis, we interposed a period in which snails experienced either a quiescent, sleeping state or an active, non-sleeping state following escape behavior suppression learning (EBSL). During EBSL training, the number of escapes made by a snail from a container was significantly suppressed using an external aversive stimulus (punishment). After training, the snails were divided into two groups. One group of snails was allowed to move freely and to experience a sleep-like quiescent state for 3 h in distilled water. The other group was stimulated with a sucrose solution every 10 min to keep them active (i.e., non-sleeping). In the memory test, escape behavior was suppressed in the group that experienced the quiescent state, whereas the suppression was not observed in snails that were kept active. Additionally, the latency of the first escape in the memory test was shorter in the snails kept active than in those that experienced the quiescent state. Together, these data are consistent with the hypothesis that a sleep-like quiescent state enhances EBSL memory consolidation in L. stagnalis.

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Circadian disruption of memory consolidation in Drosophila

Cited by 3 publications

References 94 publications

Regulation of long-term memory by a few clock neurons in <i>Drosophila</i>

Regulation of long-term memory by a few clock neurons in <i>Drosophila</i>

Breaking free from the clock’s tyranny restores memory to brain damaged flies

Sleep-like State in Pond Snails Leads to Enhanced Memory Formation

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