Circadian expression patterns of nuclear receptors

Yang, X; Downes, M; Yu, RT; Bookout, AL; He, W; Straume, M; Mangelsdorf, DJ; Evans, Ronald M.

doi:10.1621/datasets.02002

Cited by 2 publications

(2 citation statements)

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“…More than 50% of the nuclear receptors that regulate metabolism (28 of 49) exhibit circadian oscillations in their mRNA expression [163]. The ROS load in a cell profoundly influences metabolism by restricting the redox reactions in a particular direction [164].…”

Section: Circadian Rhythm In Agingmentioning

confidence: 99%

Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle

Sharma

Sethi

Tambuwala

et al. 2020

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: All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics. Autonomous cellular clocks are modulated by various pathways that are essential for robust time keeping. In addition to the canonical transcriptional translational feedback loop, several new pathways of circadian timekeeping - non-transcriptional oscillations, post-translational modifications, epigenetics and cellular signaling in the circadian clock - have been identified. The physiology of circadian rhythm is expansive, and its link to the neurodegeneration is multifactorial. Circadian rhythm disruption is prevelant in contamporary society where light-noise, shift-work, and transmeridian travel are commonplace, and is also reported from the early stages of Alzheimer's disease (AD). Circadian alignment by bright light therapy in conjunction with chronobiotics is beneficial for treating sundowning syndrome and other cognitive symptoms in advanced AD patients. We performed a comprehensive analysis of the clinical and translational reports to review the physiology of the circadian clock, delineate its dysfunction in AD, and unravel the dynamics of the vicious cycle between two pathologies. The review delineates the role of putative targets like clock proteins PER, CLOCK, BMAL1, ROR, and clock-controlled proteins like AVP, SIRT1, FOXO, and PK2 towards future approaches for management of AD. Furthermore, the role of circadian rhythm disruption in aging is delineated.

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Section: Circadian Rhythm In Agingmentioning

confidence: 99%

Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle

Sharma

Sethi

Tambuwala

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Given that some clock-controlled genes also serve as transcription factors, the expression of numerous genes may be tied to the functions of the circadian clock [1; 2]. For example, nearly half of the known nuclear receptors, including peroxisome proliferator-activated receptors (α, γ, δ) and thyroid hormone receptors (α, β), exhibit circadian expression in liver and adipose tissues, providing a possible explanation for the cyclical behavior of carbohydrate and lipid metabolism [4].…”

Section: Introductionmentioning

confidence: 99%

The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis

Ando

Takamura

Nagata

et al. 2009

Biochemical and Biophysical Research Communications

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Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for five weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH.

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Circadian expression patterns of nuclear receptors

Cited by 2 publications

References 0 publications

Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle

Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle

The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis

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