Circadian Influence on Metabolism and Inflammation in Atherosclerosis

McAlpine, Cameron S.; Świrski, Filip K.

doi:10.1161/circresaha.116.308034

Cited by 105 publications

(142 citation statements)

References 179 publications

(207 reference statements)

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“…Circadian rhythm is a fundamental biological system in humans, animals and plants that regulates various physiological functions such as sleep–wake cycle, energy metabolism, cell division, post-transcriptional regulation (Koike et al, 2012; Cardinal-Aucoin and Steel, 2016; Lopez-Minguez et al, 2016; McAlpine and Swirski, 2016; Nitschke et al, 2016), and endocrine system (Gachon et al, 2004; Lowrey and Takahashi, 2004). The master circadian clock, located in the suprachiasmatic nucleus (SCN), is an essential activator of downstream molecular events critical to the generation of circadian rhythms (Dunlap, 1999).…”

Section: Introductionmentioning

confidence: 99%

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

et al. 2016

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Biological rhythms controlled by the circadian clock are absent in embryonic stem cells (ESCs). However, they start to develop during the differentiation of pluripotent ESCs to downstream cells. Conversely, biological rhythms in adult somatic cells disappear when they are reprogrammed into induced pluripotent stem cells (iPSCs). These studies indicated that the development of biological rhythms in ESCs might be closely associated with the maintenance and differentiation of ESCs. The core circadian gene Clock is essential for regulation of biological rhythms. Its role in the development of biological rhythms of ESCs is totally unknown. Here, we used CRISPR/CAS9-mediated genetic editing techniques, to completely knock out the Clock expression in mouse ESCs. By AP, teratoma formation, quantitative real-time PCR and Immunofluorescent staining, we did not find any difference between Clock knockout mESCs and wild type mESCs in morphology and pluripotent capability under the pluripotent state. In brief, these data indicated Clock did not influence the maintaining of pluripotent state. However, they exhibited decreased proliferation and increased apoptosis. Furthermore, the biological rhythms failed to develop in Clock knockout mESCs after spontaneous differentiation, which indicated that there was no compensational factor in most peripheral tissues as described in mice models before (DeBruyne et al., 2007b). After spontaneous differentiation, loss of CLOCK protein due to Clock gene silencing induced spontaneous differentiation of mESCs, indicating an exit from the pluripotent state, or its differentiating ability. Our findings indicate that the core circadian gene Clock may be essential during normal mESCs differentiation by regulating mESCs proliferation, apoptosis and activity.Electronic supplementary materialThe online version of this article (doi:10.1007/s13238-016-0319-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

et al. 2016

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“…In line with previous studies, we found a significant increase of plasma lipid levels in JL mice supporting the link between CRD and cardiovascular diseases. [44][45][46] Besides lipid metabolism, feeding-signalling and insulin-glucose axis are also under circadian regulation. Several studies reported elevated leptin and insulin resistance in CRD associated with weight gain, obesity and type-2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice

Hadadi

Taylor

et al. 2019

Preprint

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Breast cancer is the most common type and one of the major causes of cancer death in woman worldwide. Epidemiological studies have established a link between night shift work and increased cancer risk, suggesting that circadian disruption may interfere with carcinogenesis. We aim to shed light on the effect of chronic jetlag on mammary tumour development. Therefore, we used a mouse model of spontaneous mammary tumorigenesis that we exposed to chronic circadian disruption. We observed that circadian disruption significantly increases cancer cell dissemination and metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. We finally showed that all these defects can be corrected by the use of a CXCR2 inhibitor. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression.

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“…It was well known that vascular endothelial injury in the susceptible location for atherosclerosis in vessels was the prerequisite for AS formation, while the atherosclerotic plaque was the consequence of subsequent vascular repair reaction induced by shear stress [37][38][39]. Thus, dysfunctional endothelium in the atherosclerosis-susceptible location is an early manifestation of atherosclerosis [40].…”

Section: Dual Effects Of Shear Stress On Atherosclerosismentioning

confidence: 99%

Endothelial Glycocalyx: Novel Insight into Atherosclerosis

Zeng¹

2017

J. Biomed

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The evidence shows that endothelial glycocalyx exerts an important role in inflammation and atherosclerosis. We previously demonstrated that hydrodynamic force such as shear stress induces the remodeling of the major component of glycocalyx including glypican-1 with attached heparan sulfate, and that sphingosine-1-phosphate (S1P) protects the glycocalyx against syndecan-1 ectodomain shedding and induces the synthesis of HS. Actually, both shear stress and S1P imposed significant influence on inflammatory disease such as atherosclerosis. Therefore, it can be concluded that glycocalyx is a critical signaling platform for determining the fate of endothelial cells and atherosclerosis. This review integrated our current understanding of shear stress, S1P and glycocalyx, and also provided new insight/issues into the role of the glycocalyx in the process of forming and developing atherosclerosis.

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Circadian Influence on Metabolism and Inflammation in Atherosclerosis

Cited by 105 publications

References 179 publications

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

Role of circadian gene Clock during differentiation of mouse pluripotent stem cells

Chronic circadian disruption modulates breast cancer cell stemness and their immune microenvironment to drive metastasis in mice

Endothelial Glycocalyx: Novel Insight into Atherosclerosis

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