Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease

Satlin, Andrew; Volicer, Ladislav; Stopa, Edward G.; Harper, David G.

doi:10.1016/0197-4580(95)00059-n

Cited by 257 publications

(241 citation statements)

References 26 publications

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“…Overall, these findings in the SAMP8 are similar to the agerelated rhythm disruptions reported for healthy elderly adults, individuals with senile dementia, and for other species (McAuley et al 2002;Satlin et al 1991;van Gool 1986;van Someren et al 1993a). Patients with senile dementia, in particular, show excessive levels of nighttime activity, in relation to healthy elderly of the same age (Satlin et al 1991;van Gool 1986;van Someren et al 1993a). Because the night is the normally inactive period for humans, this finding in dementia patients may be analogous to the increased daytime activity observed in aged SAMP8.…”

Section: Senescence-accelerated Mouse As a Model Of Agingsupporting

confidence: 72%

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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Common complaints of the elderly involve impaired cognitive abilities, such as loss of memory and inability to attend. Although much research has been devoted to these cognitive impairments, other factors such as disrupted sleep patterns and increased daytime drowsiness may contribute indirectly to impaired cognitive abilities. Disrupted sleep-wake cycles may be the result of age-related changes to the internal (circadian) clock. In this article, we review recent research on aging and circadian rhythms with a focus on the senescence-accelerated mouse (SAM) as a model of aging. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for age-related changes in cognition.Key words aging . C-Fos . circadian rhythms . mouse . running wheel . SAMP8 . suprachiasmatic nucleus Cognitive impairments are well-known complaints of the elderly. Despite their obvious clinical importance, many questions remain unanswered. One important issue concerns whether cognitive impairments are due to direct alterations in the cognitive function, or to other difficulties that may in turn result in cognitive deficits. For example, the elderly often report poor night-time sleep quality, daytime sleepiness, lack of energy, and difficulty adjusting to a time shift (increased "jet lag"). Could these effects contribute to cognitive impairments?Although a confluence of factors may lead to poor sleep quality, etc., it is likely that one general culprit is aging of the internal (circadian) clock that regulates these behaviors (Munch et al. 2005;Turek et al. 1995;Weitzman et al. 1982). Moreover, evidence suggests that our internal clock may also mediate cognitive functioning (Antoniadis et al. 2000;Brock 1991, Stone 1989van Gool 1986;van Someren et al. 1993a). In this article, we review recent research on aging and circadian rhythms, with a focus on the senescence-accelerated mouse line. We explore some of the neurobiological mechanisms that appear to be responsible for our aging clock, and consider implications of this work for the study of age-related changes in cognition.Circadian rhythms are predictable and regularly occurring daily changes in behavior and physiological states. The term circadian, literally meaning "around a day," has its origins in two Latin words: Circa (around) and dies (day). Two defining characteristics AGE (2006) of circadian rhythms are their continued persistence in the absence of external cues in the environment and their ability to be entrained (synchronized) by environmental cues. With respect to the former property, it is the endogenous (self-sustaining) nature of circadian rhythms that engenders an internal clock. With respect to the latter property, the major external cue that serves to synchronize the circadian rhythms of humans and other mammals is light, but almost any periodic event can act as a Zeitgeber ("time-giver").Research on the biological basis of circadian rhythms in humans and other mammals implicates the s...

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Section: Senescence-accelerated Mouse As a Model Of Agingsupporting

confidence: 72%

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Pang

Miller

Fortress

et al. 2006

AGE

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“…123 The possibility that this phenomenon is due to changes in the circadian rhythm has been proposed, 124 as these patients show a phase delay in the circadian rhythm of body temperature and in motor activity. 125 A delayed sleep-wake disorder has also been found in patients with fronto-temporal dementia. 126 …”

Section: Dementiamentioning

confidence: 98%

Circadian rhythms in cognitive performance: implications for neuropsychological assessment

Valdéz¹,

Ramírez²,

García³

2012

CPT

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Circadian variations have been found in human performance, including the efficiency to execute many tasks, such as sensory, motor, reaction time, time estimation, memory, verbal, arithmetic calculations, and simulated driving tasks. Performance increases during the day and decreases during the night. Circadian rhythms have been found in three basic neuropsychological processes (attention, working memory, and executive functions), which may explain oscillations in the performance of many tasks. The time course of circadian rhythms in cognitive performance may be modified significantly in patients with brain disorders, due to chronotype, age, alterations of the circadian rhythm, sleep deprivation, type of disorder, and medication. This review analyzes the recent results on circadian rhythms in cognitive performance, as well as the implications of these rhythms for the neuropsychological assessment of patients with brain disorders such as traumatic head injury, stroke, dementia, developmental disorders, and psychiatric disorders.

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“…In addition to these parameters, peak activity (mesor þ amplitude) to measure activity levels, the circadian quotient (amplitude/mesor) to characterise the strength of the circadian rhythm, and the rhythm quotient (A 24 h /(A 4 þ A 8 þ A 12 )) were computed. Higher amplitudes indicate more robust rhythms but people who move vigorously would have higher amplitude, thus, the circadian quotient provides normalised values that would allow comparison between individuals (Satlin et al, 1991;AncoliIsrael et al, 1997). We also looked at the dichotomy index (IoO), comparing amounts of activity when in bed and out of bed, which is significantly associated with colorectal cancer patients' quality of life and survival (Mormont et al, 2000).…”

Section: Appendix Imentioning

confidence: 99%

Circadian function in patients with advanced non-small-cell lung cancer

et al. 2005

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This study aimed to evaluate whether patients with advanced non-small-cell lung cancer experience disrupted rest -activity daily rhythms, poor sleep quality, weakness, and maintain attributes that are linked to circadian function such as fatigue. This report describes the rest -activity patterns of 33 non-small-cell lung cancer patients who participated in a randomised clinical trial evaluating the benefits of melatonin. Data are reported on circadian function, health-related quality of life (QoL), subjective sleep quality, and anxiety/depression levels prior to randomisation and treatment. Actigraphy data, an objective measure of circadian function, demonstrated that patients' rest -activity circadian function differs significantly from control subjects. Our patients reported poor sleep quality and high levels of fatigue. Ferrans and Powers QoL Index instrument found a high level of dissatisfaction with healthrelated QoL. Data from the European Organization for Research and Treatment for Cancer reported poor capacity to fulfil the activities of daily living. Patients studied in the hospital during or near chemotherapy had significantly more abnormal circadian function than those studied in the ambulatory setting. Our data indicate that measurement of circadian sleep/activity dynamics should be accomplished in the outpatient/home setting for a minimum of 4 -7 circadian cycles to assure that they are most representative of the patients' true condition. We conclude that the daily sleep/activity patterns of patients with advanced lung cancer are disturbed. These are accompanied by marked disruption of QoL and function. These data argue for investigating how much of this poor functioning and QoL are actually caused by this circadian disruption, and, whether behavioural, light-based, and or pharmacologic strategies to correct the circadian/sleep activity patterns can improve function and QoL.

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Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease

Cited by 257 publications

References 26 publications

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8)

Circadian rhythms in cognitive performance: implications for neuropsychological assessment

Circadian function in patients with advanced non-small-cell lung cancer

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