Circadian monitoring as an aging predictor

Martínez-Nicolás, Antonio; Madrid, Juan Antonio; Garcı́a, Francisco; Campos, Manuel; Moreno-Casbas, Teresa; Almaida-Pagán, P.F.; Lucas-Sánchez, Alejandro; Rol, María Ángeles

doi:10.1038/s41598-018-33195-3

Cited by 46 publications

(36 citation statements)

References 61 publications

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“…In keeping with it, our study indicates that the marker rhythms (wrist temperature, motor activity and body position), controlled in part by the central pacemaker, lose robustness with age, in spite of the small size of our sample. Also, as expected, we find here that the integrated circadian variable TAP is a useful indicator to study the human circadian behavior in aged individuals, confirming the recent demonstration of its high efficiency to discriminate aged individuals [16].…”

Section: Discussionsupporting

confidence: 91%

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Camello-Almaraz

Martín-Cano

Santos³

et al. 2020

IJMS

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Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in the circadian expression of clock genes in the human colon. Ambulatory recordings of the circadian rhythms of skin wrist temperature, motor activity and the integrated variable TAP (temperature, activity and position) were dampened by aging, especially beyond 74 years of age. On the contrary, quantitative analysis of genes expression in the muscle layer of colonic explants during 24 h revealed that the circadian expression of Bmal1, Per1 and Clock genes, was larger beyond that age. In vitro experiments showed that aging induced a parallel increase in the myogenic contractility of the circular colonic muscle. This effect was not accompanied by enhancement of Ca2+ signals. In conclusion, we describe here for the first time the presence of a molecular oscillator in the human colon. Aging has a differential effect on the systemic circadian rhythms, that are impaired by aging, and the colonic oscillator, that is strengthened in parallel with the myogenic contractility.

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Section: Discussionsupporting

confidence: 91%

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Camello-Almaraz

Martín-Cano

Santos³

et al. 2020

IJMS

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“…Other wearable biosensors have also been correlated with the circadian rhythms of patients (Innominato et al, ). For example, a recent study studied the circadian rhythms in individuals of different ages and measured several parameters such as distal skin temperature, activity, body position, light exposure, and environmental temperature, using various wearable biosensors (Martinez‐Nicolas et al, ). Recordings allowed the calculation of a coefficient (temperature activity body position) that is highly predictive of the age of the individual (Martinez‐Nicolas et al, ).…”

Section: Evaluation Of Circadian Rhythms: From Cells To Humansmentioning

confidence: 99%

“…In addition, there are other markers that can be easily measured and that can reflect circadian phases as well, such as the core body temperature, melatonin, and cortisol secretion (reviewed in Evans & Davidson, 2013). Several recent studies have selected body temperature as a determinant parameter for circadian rhythm evaluation (Garrido et al, 2017;Martinez-Nicolas et al, 2018). Body temperature can be easily measured through wristbands, usually in the non-dominant arm.…”

Section: Monitoring Of Circadian Rhythms In Humansmentioning

confidence: 99%

The importance of determining circadian parameters in pharmacological studies

Gaspar

Álvaro

Carmo‐Silva

et al. 2019

British J Pharmacology

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In mammals, most molecular and cellular processes show circadian changes, leading to daily variations in physiology and ultimately in behaviour. Such daily variations induce a temporal coordination of processes that is essential to ensure homeostasis and health. Thus, it is of no surprise that pharmacokinetics (PK) and pharmacodynamics (PD) of many drugs are also subject to circadian variations, profoundly affecting their efficacy and tolerability. Understanding how circadian rhythms influence drug PK, PD, and toxicity might significantly improve treatment efficacy and decrease related side effects. Therefore, it is essential to take circadian variations into account and to determine circadian parameters in pharmacological studies, especially when drugs have a short half‐life or target rhythmic processes. This review provides an overview of the current knowledge on circadian rhythms and their relevance to the field of pharmacology. Methodologies to evaluate circadian rhythms in vitro, in rodent models and in humans, from experimental to computational approaches, are described and discussed. Lastly, we aim at alerting the scientific, medical, and regulatory communities to the relevance of the physiological time, as a key parameter to be considered when designing pharmacological studies. This will eventually lead to more successful preclinical and clinical trials and pave the way to a more personalized treatment to the benefit of the patients.

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“…Aged humans become more sensitive to sleep and circadian rhythm creating a condition call SCR frailty. This appears due to a lack of day/night contrast, reduced sensitivity to light, napping and a sedentary lifestyle [72]. As resistance exercise can enhance muscle chronicity in mice, it would be important to determine if this would also work in humans ( Figure 2).…”

Section: Circadian Rhythm In Aging Muscle/bone Communicationmentioning

confidence: 99%

Use it or lose it to age: A review of bone and muscle communication

Bonewald

2019

Bone

159

122

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Until recently, it was assumed that the only interaction between muscle and bone is mechanical, that the muscle acts as a pulley and the bone as a lever to move the organism. A relatively new concept is that muscle, especially contracted muscle, acts as a secretory organ, regulating metabolism. An even newer concept is that bone, especially the osteocytes in bone, act as endocrine cells targeting other organs such as kidney and more recently, muscle. These two new concepts logically led to the third concept: that muscle and bone communicate via soluble factors. Crosstalk occurs through muscle factors such as myostatin, irisin, and a muscle metabolite, βaminoisobutyric acid, BAIBA, and through bone factors such as osteocalcin, transforming growth factor beta, TGFβ, Prostaglandin E2, PGE 2 and Wnts. Some of these factors have positive and some negative effects on the opposing tissue. One feature both bone and muscle have in common is that their tissues are mechanically loaded and many of their secreted factors are regulated by load. This mechanical loading, also known as exercise, has beneficial effects on many systems leading to the hypothesis that muscle and bone factors can be responsible for the beneficial effects of exercise. Many of the characteristics of aging and diseases associated with aging such as sarcopenia and osteoporosis and neurological conditions such as Alzheimer's disease and dementia, are delayed by exercise. This beneficial effect has been ascribed to increased blood flow increasing oxygen and nutrients, but could also be due to the secretome of the musculoskeletal system as outlined in this review. Effects of aging on the Musculoskeletal system Aging has overwhelming effects on bone and skeletal muscle mass. Reduced movement due to increased periods of rest and reduced physical activity most likely explains much of the reduced bone and muscle phenotype in older individuals. About the same time of age-related bone loss, osteoporosis occurs, so does age-related muscle loss, referred to as 'sarcopenia'. Muscle loss, like bone loss, actually starts soon after age 30, but becomes a rapid, progressive, debilitating condition after age 60. It is projected that in 2050, 20% of the world's population over 60 will suffer from sarcopenia and by 2150, this percentage will increase to 33% of the population[1]. Sarcopenia is associated with metabolic abnormalities, including changes in insulin sensitivity, increased fat and connective tissue infiltration in the Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Circadian monitoring as an aging predictor

Cited by 46 publications

References 61 publications

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

The importance of determining circadian parameters in pharmacological studies

Use it or lose it to age: A review of bone and muscle communication

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