Circadian periodicity of plasma lipid peroxides and anti-oxidant enzymes in pulmonary tuberculosis

Abstract

The circadian periodicity of plasma lipid peroxide levels and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were studied in 50 clinically, bactedologically and radiologically proven fresh cases of pulmonary tuberculosis (age: 21-45 years) and 60 agematched healthy volunteers with diurnal activity from 06:00 to about 22:00 and nocturnal rest. A marked circadian variation in plasma lipid peroxide level was recorded in healthy subjects and pulmonary tuberculosis patients with significant amplitude and acrophase around 16:21 and 17:12 respectively. The acrophase tended to be delayed in tuberculosis patients. Furthermore, a statistically significant circadian rhythm was found in SOD, CAT and GPx activities in normal volunteers and pulmonary tuberculopsis patients. SOD and CAT enzyme activity was noted to be maximum at 06:00 and minimum at 00:00 in tuberculosis patients. The circadian acrophase for GPx activity was recorded at 16:15 in normals and around 22:45 in patients. Moreover, the activity was found to be decreased at all sampling hours during 24-hours sleep-awake period in patients in comparison to healthy counterparts. The MESOR and circadian amplitude also decreased markedly. The decreased activity of measured antioxidant enzymes in pulmonary tuberculosis patients could probably be associated with oxidative stress and/or decreased anti-oxidant defensive mechanism in such patients.

Reconvene and Reconnect the Antioxidant Hypothesis in Human Health and Disease

“…Since FR were accused as causal factors in a large number of diseases, these were sometimes referred as ''Free Radical Diseases''. Some of the important diseases and health issues in this category are cancer [61][62][63][64][65][66][67], cardiovascular diseases [68][69][70][71][72][73], atherosclerosis [74][75][76][77][78][79][80][81], neurological disorders [82][83][84][85][86], renal disorders [87][88][89][90], liver disorders [91][92][93], hypertension [50,94,95], rheumatoid arthritis [96,97], adult respiratory distress syndrome, auto-immune deficiency diseases [98,99], inflammation, degenerative disorders associated with aging [100][101][102][103], diabetes mellitus [104][105]…”

Influence of Simvastatin Chronotherapy on Erythrocytes Nitric oxide Synthase Activity

“…Several studies reported that there is a day and night fluctuation of oxidative stress parameters in animals and in humans (Singh et al, 2004;Subash and Subramanian, 2007;Chakravarty and Rizvi, 2011;Xu et al, 2012). Herein, simvastatin treatment preserves T-SH level compared to basal levels.…”

“…The suprachiasmatic nucleus drives the daily regulation of biological signals. Consequently, a marked oscillations of organ functions, biochemical pathways and other biological processes were observed during 24 h (Singh et al, 2004;Subash and Subramanian, 2007). So that understanding functions of biological clock and identification of modalities to manipulate this system enable us to establish chronotherapy (Biswas et al, 2014).…”

“…It has been reported that cholesterol biosynthesis, glucose homeostasis, oxidant/antioxidant balance and many other biochemical process have a marked diurnal variations (Singh et al, 2004;Subash and Subramanian, 2007;Favero et al, 2014).…”

Effects of cutting parameters during turning 100C6 steel

“…1. The process parameters affecting the characteristics of turned parts are: cutting tool parameters, workpiece properties, cutting phenomena and cutting parameters [6]. Cutting tests were carried out on a CNC SOMAB model 500 lathe machine (24kW power) under dry cutting conditions.…”