Circadian reactivity rhythms of human skin to histamine or allergen and the adrenal cycle

Reinberg, Alain; Sidi, E; Ghata, J

doi:10.1016/0021-8707(65)90086-9

Cited by 79 publications

(18 citation statements)

References 9 publications

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“…58,59], no temporal correlations were observed between the levels of these other substances in CSF or in plasma. Similarly, the diurnal rhythm of the histamine metabolites in CSF of a non-human primate are also different from the diurnal changes of histamine levels in human plasma [64] and of histamine-induced allergic responses [65]. In rats and mice, the diurnal rhythms of the levels of t-MH observed in brain were not seen in plasma [19].…”

Section: Discussionmentioning

confidence: 96%

Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey

Prell

Khandelwal²,

Burns³

et al. 1989

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In samples of ventricular cerebrospinal fluid (CSF) that were collected from a conscious, restrained rhesus monkey at intervals of 30 90 min, levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), were determined by gas chromatography-mass spectrometry. Levels of t-MH and t-MIAA each showed time-related fluctuations. Peak and trough concentrations of t-MIAA, the product of t-MH, paralleled, but lagged about 2 h behind, the levels of t-MH. Within the first 3 h of illumination, metabolite levels increased more than 3-fold; they fell sharply within the first 3 h of darkness. Mean levels of t-MH and t-MIAA were significantly higher during periods of illumination than of darkness. Fluctuations in the levels of pros-methylimidazoleacetic acid (p-MIAA), an endogenous isomer of t-MIAA that is not a histamine metabolite, were markedly different from those of t-MH or t-MIAA; p-MIAA levels peaked only at the middle of the dark period. The time-related fluctuations in levels of t-MH and t-MIAA, but not p-MIAA, are similar to the daily rhythmic changes observed in monkey CSF for the levels of other central neurotransmitters and peptide neurohormones.

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Section: Discussionmentioning

confidence: 96%

Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey

Prell

Khandelwal²,

Burns³

et al. 1989

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“…It has been suggested that this phenomenon is related at least in part to the fall in cortisol levels seen at night (17,18), although efforts to demonstrate this conclusively have not been successful (19). Circadian variation in rhinitis and immediate cutaneous responses to antigen, 48/80, and histamine have also been described, but none have been linked directly to changes in endogenous cortisol (20)(21)(22). In man, IgE-dependent mast cell stimulation typically results in a biphasic clinical response.…”

Section: Introductionmentioning

confidence: 99%

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Herrscher

Kasper²,

Sullivan³

1992

J. Clin. Invest.

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To investigate the impact that physiological variation in serum cortisol has on IgE-mediated events, 10 atopic subjects underwent cutaneous antigen challenge with measurement of the early phase wheal (EPW) at 20 min and the late phase reaction (LPR) at 6 h. All subjects were challenged during control conditions between 8:00 and 9:00 a.m. Repeat challenges were performed in five subjects at 6:00 p.m. and in eight subjects after ingestion of metyrapone, a specific inhibitor of cortisol synthesis. Compared with control values, mean serum cortisol was suppressed in the evening and after metyrapone (P < 0.05 all time points). No effect was seen on the EPW, but mean LPR diameters at three antigen dilutions were significantly increased by cortisol suppression (P < 0.05). Replacement doses of hydrocortisone given in the evening and with metyrapone abrogated these increases. Blinded analysis of LPR biopsies from cortisol-suppressed subjects revealed increases in leukocytoclasis (P < 0.0001), interstitial leukocytes (P . 0.01), and eosinophils (P s 0.04). These results indicate that physiological levels of serum cortisol can regulate IgE-dependent cutaneous inflammation by affecting the expression of cellular events at late phase sites. (J. Clin. Invest. 1992. 90:596-603.)

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“…In this study, the choice of 2 ,ug histamine and the time of wheal measurements were based on a preliminary dose-ranging study in these volunteers. A circadian rhythm in the histamine wheal response has been described (Reinberg et al, 1965;Peck et al, 1975). Our study was placebo controlled in an attempt to reduce such confounding factors.…”

Section: Discussionmentioning

confidence: 99%

The pharmacokinetics, antihistamine and concentration‐effect relationship of ebastine in healthy subjects.

Vincent

Liminana

Meredith

et al. 1988

Brit J Clinical Pharma

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1. The kinetics and effects of ebastine 10 and 50 mg were studied after oral dosing in healthy subjects. 2. The parent drug was extensively metabolised during the first pass to its carboxylic acid derivative, carebastine. 3. The pharmacokinetics of carebastine were linear over the dose range studied and the terminal elimination half‐life was 10.6 +/‐ 2.6 and 12.5 +/‐ 1.9 h respectively after 10 and 50 mg of ebastine. 4. Antihistamine (H1‐receptor) activity was examined with intradermal histamine (2 micrograms). Oral ebastine reduced the histamine wheal area for up to 24 h and also reduced subjective local pain. 5. Antihistamine activity correlated well with plasma levels of carebastine in individual subjects. 6. Ebastine appears to have potential as an antihistamine for once a day dosing.

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Circadian reactivity rhythms of human skin to histamine or allergen and the adrenal cycle

Cited by 79 publications

References 9 publications

Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey

Diurnal fluctuation in levels of histamine metabolites in cerebrospinal fluid of rhesus monkey

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

The pharmacokinetics, antihistamine and concentration‐effect relationship of ebastine in healthy subjects.

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