Circadian regulation by REV-ERBα mediates hippocampal E-LTP in a time-dependent manner

Choi, Ja Eun; Kim, Somi; Lee, Jisu; Kim, Kyungjin; Kim, Minjeong; Hong, Ilgang; Kaang, Bong‐Kiun

doi:10.1016/j.ibror.2019.07.1270

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“…Likewise, a brief 5~6 h period of SD has been shown to impair the consolidation of object-place memory for which the hippocampus is required [6]. Long-term potentiation (LTP), a long-lasting change in the strength of synaptic connections, is a widely studied cellular model of synaptic plasticity and is believed to be responsible for the hippocampus-dependent L&M [7,8]. Rapid-eye movement (REM) sleep restriction for 21 days decreased LTP and long-term memory, and even 3~4 hours of total SD already reduced LTP in the granule cells of the dentate gyrus (DG) [9,10].…”

Section: Introductionmentioning

confidence: 99%

β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats

2021

Exp Neurobiol

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Sleep deprivation (SD) leads to cognitive impairment, especially hippocampus-dependent learning and memory (L&M). The hippocampal dentate gyrus (DG) is the key structure involved in spatial L&M while long-term potentiation (LTP) is an important cellular mechanism responsible for L&M. Physiological and behavioral evidences support the hypothesis that norepinephrine (NE) and β-adrenoceptors (β-AR) may play an important role in regulating L&M, including LTP. However, it is enigmatic how β-AR influences the LTP disruption or memory impairment under SD circumstances. In the present study, the rats were subjected to SD for 18 h per day for 21 consecutive days and cognitive capacity was assessed by the Morris water maze (MWM) test. We examined the extracellular concentration of NE in the DG using in vivo brain microdialysis and HPLC analysis. The amplitudes of field excitatory postsynaptic potential (fEPSP) were subsequently measured in the DG during MWM test in freely moving conscious rats. The extracellular concentrations of NE and fEPSP amplitudes in the DG were significantly increased during MWM test, while these responses were suppressed in SD rats. When fEPSP amplitudes in the DG were measured after local injection of isoproterenol (an agonist of β-AR), SD rats significantly alleviated the fEPSP impairment and rescued deficits of spatial L&M. In addition, the reduced expression of N-methyl-Daspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in SD rats significantly increased by activation of β-AR by isoproterenol in the DG. In conclusion, we propose that β-adrenergic signaling can improve memory impairment in sleep-deficient rats by regulating synaptic efficiency and glutamatergic receptor expression.

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Section: Introductionmentioning

confidence: 99%

β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats

2021

Exp Neurobiol

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Circadian regulation by REV-ERBα mediates hippocampal E-LTP in a time-dependent manner

Cited by 1 publication

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β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats

β-adrenergic Receptor Activity in the Hippocampal Dentate Gyrus Participates in Spatial Learning and Memory Impairment in Sleep-deprived Rats

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