Circadian regulation of pineal gland rhythmicity

Borjigin, Jimo; Zhang, L. Samantha; Calinescu, Anda-Alexandra

doi:10.1016/j.mce.2011.07.009

Cited by 131 publications

(99 citation statements)

References 101 publications

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“…As previously noted, melatonin secretion during the night (in both nocturnal and diurnal mammals) is regulated by SCN pacemaker neurons [47]. Melatonin has established and Fig.…”

Section: Sleep Disturbance Circadian Disruption and Altered Glucosementioning

confidence: 70%

“…Melatonin is considered the primary 'chronobiotic' hormone, regulating coordination within the timing system [46]. It is secreted from pinealocytes during the night in both nocturnal and diurnal mammals [47]. It has been proposed that this hormone may have a potential role as a therapeutic agent for metabolic disease, given its established influence on glucose homeostasis (see Fig.…”

Section: The Internal Timing System and Metabolic Dysfunctionmentioning

confidence: 99%

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Chronomedicine and type 2 diabetes: shining some light on melatonin

et al. 2016

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In mammals, the circadian timing system drives rhythms of physiology and behaviour, including the daily rhythms of feeding and activity. The timing system coordinates temporal variation in the biochemical landscape with changes in nutrient intake in order to optimise energy balance and maintain metabolic homeostasis. Circadian disruption (e.g. as a result of shift work or jet lag) can disturb this continuity and increase the risk of cardiometabolic disease. Obesity and metabolic disease can also disturb the timing and amplitude of the clock in multiple organ systems, further exacerbating disease progression. As our understanding of the synergy between the timing system and metabolism has grown, an interest has emerged in the development of novel clock-targeting pharmaceuticals or nutraceuticals for the treatment of metabolic dysfunction. Recently, the pineal hormone melatonin has received some attention as a potential chronotherapeutic drug for metabolic disease. Melatonin is well known for its sleep-promoting effects and putative activity as a chronobiotic drug, stimulating coordination of biochemical oscillations through targeting the internal timing system. Melatonin affects the insulin secretory activity of the pancreatic beta cell, hepatic glucose metabolism and insulin sensitivity. Individuals with type 2 diabetes mellitus have lower night-time serum melatonin levels and increased risk of comorbid sleep disturbances compared with healthy individuals. Further, reduced melatonin levels, and mutations and/or genetic polymorphisms of the melatonin receptors are associated with an increased risk of developing type 2 diabetes. Herein we review our understanding of molecular clock control of glucose homeostasis, detail the influence of circadian disruption on glucose metabolism in critical peripheral tissues, explore the contribution of melatonin signalling to the aetiology of type 2 diabetes, and discuss the pros and cons of melatonin chronopharmacotherapy in disease management.

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“…As previously noted, melatonin secretion during the night (in both nocturnal and diurnal mammals) is regulated by SCN pacemaker neurons [47]. Melatonin has established and Fig.…”

Section: Sleep Disturbance Circadian Disruption and Altered Glucosementioning

confidence: 70%

Section: The Internal Timing System and Metabolic Dysfunctionmentioning

confidence: 99%

Chronomedicine and type 2 diabetes: shining some light on melatonin

et al. 2016

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“…The release of melatonin from the pineal gland is synchronized with the daylight cycle by a multisynaptic pathway. Melatonin secretion from pineal gland is inhibited by light [4,5]. Melatonin affects various physiologic functions such as heart rate, arterial blood pressure, arterial dispensability, immune system and oxidation [4][5][6].…”

Section: Original Papersmentioning

confidence: 99%

Association of Endogenous Melatonin with Uric Acid and Traditional Cardiovascular Risk Factors in Healthy Young Male

Yıldız¹,

Şahin²,

Aladağ³

et al. 2015

Adv Clin Exp Med

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Background. Uric acid may act as an antioxidant; high serum uric acid levels are often associated with cardiovascular disease, such as coronary artery disease. Melatonin plays a role as a direct free radical scavenger and indirect antioxidant. No study has examined the relationships between endogenous melatonin and uric acid in order to predict the risk of future cardiovascular disease in male so far. To better characterize a possible relationship, we studied the association of endogenous melatonin with uric acid and traditional cardiovascular risk factors such as plasma lipids, and glucose in healthy young male. Material and Methods. Twenty-one male participants [mean age: 22.6 2.5 (18-26) year], non-smoking; their medication or alcohol consumption history were studied. Blood samples for measuring melatonin concentrations were collected in the supine position between 13:30-14:30 hours. After centrifugation, plasma samples were immediately frozen at -20°C until analysis. Results. Although we found a significant negative correlation between the levels of endogeneous melatonin and uric acid (p = 0.01, r = -0.51), we did not find any correlation among the melatonin and other antropometric, hemodynamic and biochemical parameters in male subjects (p > 0.41).Conclusions. The present study demonstrated that a significant negative correlation between the levels of endogeneous melatonin and uric acid in healthy young male (Adv Clin Exp Med 2015, 24, 2, 233-237).

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“…Em pinealócitos e outras células que produzem melatonina, a serotonina é acetilada a N-acetilserotonina (NAS) por ação da enzima arilalquilamina-N-acetiltransferase (AA-NAT) que sob efeito da enzima hidroxindol-O-metiltransferase (HIOMT), também conhecida como acetilserotonina metiltransferase (ASMT) é convertida em melatonina (Nacetil-5-metoxitriptamina) (Klein et al, 1981). ASMT é o passo limitante desta reação, visto que é a enzima que impõe a menor velocidade de reação, mas a AA-NAT é uma enzima chave, visto que a transcrição do gene e a ativação da enzima são estritamente reguladas por luz e por mediadores da inflamação (Borjigin et al, 2012).…”

Section: Melatonina: Aspectos Geraisunclassified

Melatonina sintetizada por microglias de cerebelo em cultura regula o processo de fagocitose

Santos¹

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Circadian regulation of pineal gland rhythmicity

Cited by 131 publications

References 101 publications

Chronomedicine and type 2 diabetes: shining some light on melatonin

Chronomedicine and type 2 diabetes: shining some light on melatonin

Association of Endogenous Melatonin with Uric Acid and Traditional Cardiovascular Risk Factors in Healthy Young Male

Melatonina sintetizada por microglias de cerebelo em cultura regula o processo de fagocitose

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