Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective

Karatsoreos, Ilia N.

doi:10.1007/7854_2019_115

Cited by 8 publications

(5 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A more nuanced picture has emerged of a heterogeneous population of neurons in the SCN clock, sensitive to light but also to signals such as hormonal cues ( Karatsoreos, 2019 ; Karatsoreos and Silver, 2007 ; Mong et al, 2011 ) and thermal signals ( Abraham et al, 2010 ; Bordyugov et al, 2015 ; Herzog and Huckfeldt, 2003 ; Ruby et al, 1999 ). In mammals, light provides the primary input to the SCN, and here it is integrated with non-photic zeitgebers ( Ashton et al, 2022 ).…”

Section: From Silver To Gold: Scn In the Second 25 Years 1998 To 2022mentioning

confidence: 99%

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward

Ono,

Weaver,

Hastings

et al. 2024

J Biol Rhythms

View full text Add to dashboard Cite

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the central circadian clock and 25 years since the last overview of developments in the field was published in the Journal of Biological Rhythms. Here, we explore new mechanisms and concepts that have emerged in the subsequent 25 years. Since 1997, methodological developments, such as luminescent and fluorescent reporter techniques, have revealed intricate relationships between cellular and network-level mechanisms. In particular, specific neuropeptides such as arginine vasopressin, vasoactive intestinal peptide, and gastrin-releasing peptide have been identified as key players in the synchronization of cellular circadian rhythms within the SCN. The discovery of multiple oscillators governing behavioral and physiological rhythms has significantly advanced our understanding of the circadian clock. The interaction between neurons and glial cells has been found to play a crucial role in regulating these circadian rhythms within the SCN. Furthermore, the properties of the SCN network vary across ontogenetic stages. The application of cell type–specific genetic manipulations has revealed components of the functional input-output system of the SCN and their correlation with physiological functions. This review concludes with the high-risk effort of identifying open questions and challenges that lie ahead.

show abstract

Section: From Silver To Gold: Scn In the Second 25 Years 1998 To 2022mentioning

confidence: 99%

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward

Ono,

Weaver,

Hastings

et al. 2024

J Biol Rhythms

View full text Add to dashboard Cite

show abstract

“…Both neurons have also been linked with control of ovulation [ 173 , 202 , 203 , 204 ]. For instance, AVP, that mediates SCN output, triggers the LH surge through activating kisspeptin neurons in AVPV, which project to the mPOA [ 205 , 206 ]. VIP neurons, in turn, project to the mPOA and control the timing of the LH surge via the triggering of GnRH neurons [ 206 ].…”

Section: Menopausementioning

confidence: 99%

“…For instance, AVP, that mediates SCN output, triggers the LH surge through activating kisspeptin neurons in AVPV, which project to the mPOA [ 205 , 206 ]. VIP neurons, in turn, project to the mPOA and control the timing of the LH surge via the triggering of GnRH neurons [ 206 ]. According to Krajnak et al [ 186 ] and Davidson et al [ 207 ], the molecular clock rhythm itself does not change significantly in aged animals.…”

Section: Menopausementioning

confidence: 99%

Circle(s) of Life: The Circadian Clock from Birth to Death

Olejniczak

Pilorz

Oster

2023

Biology

View full text Add to dashboard Cite

Most lifeforms on earth use endogenous, so-called circadian clocks to adapt to 24-h cycles in environmental demands driven by the planet’s rotation around its axis. Interactions with the environment change over the course of a lifetime, and so does regulation of the circadian clock system. In this review, we summarize how circadian clocks develop in humans and experimental rodents during embryonic development, how they mature after birth and what changes occur during puberty, adolescence and with increasing age. Special emphasis is laid on the circadian regulation of reproductive systems as major organizers of life segments and life span. We discuss differences in sexes and outline potential areas for future research. Finally, potential options for medical applications of lifespan chronobiology are discussed.

show abstract

“…Circadian rhythms are psychological, physiological, and physical oscillations that follow a 24 h pattern [ 1 , 2 , 3 ]. Although circadian rhythms are endogenously self-sustained, they may be influenced by various external factors including light–dark cycle, environment, ambient temperature, and feeding state/dietary intake [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters

Dumar

Huntington

Rogers

et al. 2021

IJERPH

View full text Add to dashboard Cite

Diurnal fluctuations in power output have been well established with power loss typically occurring in morning (AM) times. Beetroot juice (BRJ) is a source of dietary nitrate that possess ergogenic properties, but it is unknown if ingestion can mitigate performance decrements in the morning. The purpose of this study was to examine the effects of acute BRJ supplementation on diurnal fluctuations in anaerobic performance in trained sprinters. Male Division 1 National Collegiate Athletic Association (NCAA) sprinters (n = 10) participated. In a double-blinded crossover study design, participants completed three counterbalanced exercise trials under different conditions: Morning–placebo (8:00 HR, AM-PL), Morning–BRJ (8:00 HR, AM-BRJ), and Afternoon–no supplement (15:00 HR, PM). For each trial, participants completed 3 × 15 s Wingate anaerobic tests separated by 2 min of rest. Each trial was separated by a 72 h washout period. Mean power output (p = 0.043), anaerobic capacity (p = 0.023), and total work (p = 0.026) were significantly lower with the AM-PL condition compared to PM. However, BRJ supplementation prevented AM losses of mean power output (p = 0.994), anaerobic capacity (p = 0.941), and total work (p = 0.933) in the AM-BRJ compared to the PM condition. Rate of perceived exertion was not significantly different between any conditions (p = 0.516). Heart rate was significantly lower during the AM-BRJ condition compared to AM-PL (p = 0.030) and PM (p < 0.001). Findings suggest anaerobic capacity suffers during AM versus PM times in trained sprinters, but BRJ ingestion abolishes AM-associated decrements in performance.

show abstract

Circadian Regulation of the Brain and Behavior: A Neuroendocrine Perspective

Cited by 8 publications

References 187 publications

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward

The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward

Circle(s) of Life: The Circadian Clock from Birth to Death

Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters

Contact Info

Product

Resources

About