Circadian Relationships between Circulating Atrial Natriuretic Peptides and Serum Sodium and Chloride in Healthy Humans

Sothern, Robert B.; Vesely, David L.; Kanabrocki, Eugene L.; Bremner, Fraser W.; Third, Jane L.H.C.; McCormick, James B.; Dawson, Susan; Ryan, M.; Greco, J; Bean, Jeff T.; Nemchausky, Bernard M.; Shirazi, Parvez; Scheving, Lawrence E.

doi:10.1159/000169045

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…There was a consensus (15/17) that SSCs can be performed at any time of day and are not affected by whether or not the stomach is empty (although note that polydipsia is a contraindication of the drug). There is sufficient literature to support that a sodium check can be done at any time of the day …”

Section: Resultsmentioning

confidence: 99%

International Continence Society consensus on the diagnosis and treatment of nocturia

Everaert

Hervé

Bosch

et al. 2019

Neurourology and Urodynamics

109

104

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Introduction Patients with nocturia have to face many hurdles before being diagnosed and treated properly. The aim of this paper is to: summarize the nocturia patient pathway, explore how nocturia is diagnosed and treated in the real world and use the Delphi method to develop a practical algorithm with a focus on what steps need to be taken before prescribing desmopressin. Methods Evidence comes from existing guidelines (Google, PubMed), International Consultation on Incontinence‐Research Society (ICI‐RS) 2017, prescribing information and a Delphi panel (3 rounds). The International Continence Society initiated this study, the authors represent the ICI‐RS, European Association of Urology, and Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction (SUFU). Results Diagnostic packages: consensus on, history taking for all causalities, intake diary (fluid, food) and bladder diary, not for its duration. Pelvic (women) or rectal (men) examination, prostate‐specific antigen, serum sodium check (SSC), renal function, endocrine screening: when judged necessary. Timing or empty stomach when SSC is not important. Therapeutic packages: the safe candidates for desmopressin can be phenotyped as no polydipsia, heart/kidney failure, severe leg edema or obstructive sleep apnea syndrome. Lifestyle interventions may be useful. Initiating desmopressin: risk management consensus on three clinical pictures. Follow‐up of desmopressin therapy: there was consensus on SSC day 3 to 7, and at 1 month. Stop therapy if SSC is <130 mmol/L regardless of symptoms. Stop if SSC is 130 to 135 mmol/L with symptoms of hyponatremia. Conclusion A summary of the nocturia patient pathway across different medical specialists is useful in the visualization and phenotyping of patients for diagnosis and therapy. By summarizing basic knowledge of desmopressin, we aim to ease its initiation and shorten the patient journey for nocturia.

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Section: Resultsmentioning

confidence: 99%

International Continence Society consensus on the diagnosis and treatment of nocturia

Everaert

Hervé

Bosch

et al. 2019

Neurourology and Urodynamics

109

104

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“…Little information is available on circadian changes in these plasma variables. However, Sothern et al . (1996) did report a significant circadian variation in serum Na in humans, with peak values in the afternoon, which is in agreement with our results.…”

Section: Discussionmentioning

confidence: 99%

Circadian variation of plasma atrial natriuretic peptide, cortisol and fluid balance in the goat

Kokkonen

Riskilä

Roihankorpi

et al. 2001

Acta Physiologica Scandinavica

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Circadian variation of plasma atrial natriuretic peptide (ANP), cortisol and fluid balance was studied in ten adult female goats. The concentrations of plasma antidiuretic hormone (ADH), electrolytes, creatinine and total protein, as well as plasma and urine osmolalities and renal electrolyte excretion and clearances (Cosm, CH2O, Ccrea), were used to evaluate fluid balance. At 3-h intervals, urine was collected from five goats and venous blood samples from all ten goats. Urethral catheterization had no effect on the results. Besides the lower plasma creatinine level in the dark than in daylight, no other changes were observed in relation to luminousness. Plasma concentrations of ANP, ADH, total protein and K, urine flow rate and osmolality, urine concentrations of Na, K and creatinine, renal Na and K excretion, Cosm, CH2O and Ccrea, and haematocrit showed no circadian variation. Circadian variation was observed in plasma osmolality (P < 0.05) and the concentrations of Na (P < 0.05) and creatinine (P < 0.05), with achrophases around 16:00 hours and nadirs between 01:00 and 07:00 hours. Changes in osmolality and Na followed the feeding schedule. There was a small elevation in plasma cortisol levels in six goats after midnight, which may be the consequence of circadian rhythm. In conclusion, the results suggest that in plasma ANP no circadian rhythm exists.

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“…There is a noticeable evidence of the existence of a circadian rhythm in potassium and sodium ion concentrations [38–40]. Kanabrocki et al [41] additionally studied a circadian rhythm in calcium ion concentration; however, the results were not statistically significant, probably due to the rather small number of subjects included in the study.…”

Section: Materials Methods and Resultsmentioning

confidence: 99%

Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level

Fijorek

Püsküllüoğlu

Polak

2013

Computational and Mathematical Methods in Medicine

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In the article a brief description of the biological basis of the regulation of human biological clocks was presented in order to introduce the role of circadian rhythms in physiology and specifically in the pharmacological translational tools based on the computational physiology models to motivate the need to provide models of circadian fluctuation in plasma cations. The main aim of the study was to develop statistical models of the circadian rhythm of potassium, sodium, and calcium concentrations in plasma. The developed ion models were further tested by assessing their influence on QT duration (cardiac endpoint) as simulated by the biophysically detailed models of human left ventricular cardiomyocyte. The main results are model equations along with an electronic supplement to the article that contains a fully functional implementation of all models.

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Circadian Relationships between Circulating Atrial Natriuretic Peptides and Serum Sodium and Chloride in Healthy Humans

Cited by 16 publications

References 25 publications

International Continence Society consensus on the diagnosis and treatment of nocturia

International Continence Society consensus on the diagnosis and treatment of nocturia

Circadian variation of plasma atrial natriuretic peptide, cortisol and fluid balance in the goat

Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level

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