Circadian rhythm abnormalities of deep body temperature in depressive disorders

Daimon, Kazushi; Yamada, Naoto; Tsujimoto, Tetsushi; Takahashi, Saburo

doi:10.1016/0165-0327(92)90015-x

Cited by 47 publications

(20 citation statements)

References 30 publications

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“…Comparison of the temperature data with clinical studies indicate a similarity with drugfree patients with endogenous depression who had significantly higher temperature minima than did normol controls, also resulting in a reduction of the amplitude of daily temperature rhythm (Beersma et al, 1983;Daimon et al, 1992). The time course of the temperature response during chronic CRF infusion, as observed in the present study, furthermore at first sight shows a striking similarity to that of the temperature response following social defeat (Meerlo et al, 1996a).…”

Section: Discussionmentioning

confidence: 99%

Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat

Buwalda

Boer

Kalkeren

et al. 1997

Psychoneuroendocrinology

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Section: Discussionmentioning

confidence: 99%

Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat

Buwalda

Boer

Kalkeren

et al. 1997

Psychoneuroendocrinology

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“…This apparently paradoxical pattern, that is, longer duration of activity accompanied by lower intensity of activity, corresponds to the activity pattern in human patients with depressive episode. 45 Mood disturbance is thought to be caused by alteration of monoaminergic neurotransmission in brain. 3,46 The 'monoamine hypothesis' was mainly based on the action mechanisms of antidepressants and antimanic agents, and this has gradually been confirmed by clinical and postmortem brain studies.…”

Section: Face Validitymentioning

confidence: 99%

Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes

et al. 2006

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There is no established genetic model of bipolar disorder or major depression, which hampers research of these mood disorders. Although mood disorders are multifactorial diseases, they are sometimes manifested by one of pleiotropic effects of a single major gene defect. We focused on chronic progressive external ophthalmoplegia (CPEO), patients with which sometimes have comorbid mood disorders. Chronic progressive external ophthalmoplegia is a mitochondrial disease, which is accompanied by accumulation of mitochondrial DNA (mtDNA) deletions caused by mutations in nuclear-encoded genes such as POLG (mtDNA polymerase). We generated transgenic mice, in which mutant POLG was expressed in a neuron-specific manner. The mice showed forebrain-specific defects of mtDNA and had altered monoaminergic functions in the brain. The mutant mice exhibited characteristic behavioral phenotypes, a distorted day-night rhythm and a robust periodic activity pattern associated with estrous cycle. These abnormal behaviors resembling mood disorder were worsened by tricyclic antidepressant treatment and improved by lithium, a mood stabilizer. We also observed antidepressant-induced mania-like behavior and long-lasting irregularity of activity in some mutant animals. Our data suggest that accumulation of mtDNA defects in brain caused mood disorder-like mental symptoms with similar treatment responses to bipolar disorder. These findings are compatible with mitochondrial dysfunction hypothesis of bipolar disorder.

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“…It has been reported that idiopathic depression exhibits abnormalities in circadian rhythms of various physiological parameters in CBT including decreased amplitude or phase advance [13,14] ; however, little is known about the biological rhythm in comorbidity of depression and PD.…”

Section: Introductionmentioning

confidence: 99%

Circadian Variation of Core Body Temperature in Parkinson Disease Patients with Depression: A Potential Biological Marker for Depression in Parkinson Disease

Suzuki

Miyamoto²,

Miyamoto³

et al. 2007

Neuropsychobiology

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Background: The biological rhythm in comorbidity of depression and Parkinson disease (PD) is still unclear. For early diagnosis or clarification of the pathologic condition of comorbidity of depression and PD, the present study investigated the presence of circadian rhythm abnormalities in patients with depression. Methods: We measured the rectal temperature (RT) in 30 PD patients with or without depression during 48 consecutive hours using the maximum entropy method (MEM) and least-squares method (COSINOR). The presence of major or minor depression was evaluated by the Mini International Neuropsychiatric Interview based on the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders, and the Hamilton Depression Scale. Results: The RT rhythms of patients without depression predominately showed a circadian rhythm. However, 2 of 6 patients with depression showed an infradian rhythm using MEM. COSINOR revealed that PD patients with depression showed lower amplitudes of core body temperature (p = 0.012) and higher minimum RT (p = 0.031) relative to those of patients without depression. Conclusion: PD patients with depression show an altered RT circadian rhythm. The results suggest that the characteristics of core body temperature could be potentially used as a biological marker for depression in PD.

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Circadian rhythm abnormalities of deep body temperature in depressive disorders

Cited by 47 publications

References 30 publications

Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat

Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat

Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes

Circadian Variation of Core Body Temperature in Parkinson Disease Patients with Depression: A Potential Biological Marker for Depression in Parkinson Disease

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