Circadian Rhythm of Cardiovascular Disease: The Potential of Chronotherapy With Aspirin

Buurma, Marleen; Diemen, Jeske Joanna Katarina van; Thijs, Abel; Numans, Mattijs E.; Bonten, Tobias N

doi:10.3389/fcvm.2019.00084

Cited by 37 publications

(26 citation statements)

References 71 publications

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“…Indeed, manifestations of immune systemrelated diseases, such as rheumatoid arthritis, allergic rhinitis, or bronchial asthma, are most pronounced at night and around awakening, which correlates with a high level of proinflammatory cytokines in the circulation (22,23). Cardiovascular events such as stroke, myocardial infarction, arrhythmias, and sudden cardiac death are more likely to occur in the morning, which is linked to an increase in sympathetic tone, blood pressure, heart rate, and platelet aggregation (24,25). Symptoms from a part of the nervous system also follow circadian modulation.…”

Section: Circadian Rhythms In Diseasementioning

confidence: 99%

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

Smyk

Luijtelaar

2020

Front. Neurol.

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Many physiological processes such as sleep, hormonal secretion, or thermoregulation, are expressed as daily rhythms orchestrated by the circadian timing system. A powerful internal clock mechanism ensures proper synchronization of vital functions within an organism on the one hand, and between the organism and the external environment on the other. Some of the pathological processes developing in the brain and body are subjected to circadian modulation as well. Epilepsy is one of the conditions which symptoms often worsen at a very specific time of a day. Variation in peak occurrence depends on the syndrome and localization of the epileptic focus. Moreover, the timing of some types of seizures is closely related to the sleep-wake cycle, one of the most prominent circadian rhythms. This review focuses on childhood absence epilepsy (CAE), a genetic generalized epilepsy syndrome, in which both, the circadian and sleep influences play a significant role in manifestation of symptoms. Human and animal studies report rhythmical occurrence of spike-wave discharges (SWDs), an EEG hallmark of CAE. The endogenous nature of the SWDs rhythm has been confirmed experimentally in a genetic animal model of the disease, rats of the WAG/Rij strain. Well-known detrimental effects of circadian misalignment were demonstrated to impact the severity of ongoing epileptic activity. SWDs are vigilance-dependent in both humans and animal models, occurring most frequently during passive behavioral states and light slow-wave sleep. The relationship with the sleep-wake cycle seems to be bidirectional, while sleep shapes the rhythm of seizures, epileptic phenotype changes sleep architecture. Circadian factors and the sleep-wake states dependency have a potential as add-ons in seizures' forecasting. Stability of the rhythm of recurrent seizures in individual patients has been already used as a variable which refines existing algorithms for seizures' prediction. On the other hand, apart from successful pharmacological approach, circadian hygiene including sufficient sleep and avoidance of internal desynchronization or sleep loss, may be beneficial for patients with epilepsy in everyday management of seizures.

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Section: Circadian Rhythms In Diseasementioning

confidence: 99%

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

Smyk

Luijtelaar

2020

Front. Neurol.

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“…Recent evidence indicates that the circadian rhythm in the vasculature is important for vascular function and health [ 72 , 73 , 74 ]. The misalignment between the clock and metabolism can cause cardiovascular complications, including pathological vascular remodeling, vascular senescence, hypertension, stenotic atherosclerotic lesions, vascular graft failure, and diabetic vasculopathies [ 44 , 75 , 76 , 77 , 78 ]. Compromised circadian clock machineries in the vasculature, including mutations or polymorphisms in clock genes and the reduction in the oscillation amplitude of the clock genes, are observed in models of obesity and cellular senescence [ 70 , 79 ].…”

Section: Circadian Disruption and Vascular Complicationsmentioning

confidence: 99%

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Man

Xia

2021

IJMS

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Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock.

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“…Chronotherapy with low-dose aspirin shows a greater decrease in early morning platelet activity after evening intake compared with morning intake. 75 A high-amplitude circadian rhythm of the renin-angiotensin-aldosterone system is activated during sleep, which suggests that the administration of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers at bedtime has a greater effect than when they are administered in the morning. Bedtime chronotherapy with conventional hypertension medication results in a 61% reduction in cardiovascular events compared with morning administration.…”

Section: Main Textmentioning

confidence: 99%

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

Ilan

2020

Molecular Therapy - Methods & Clinical Development

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Chronic administration of drugs leads to the activation of compensatory mechanisms that may inhibit some of their activity and induce unwanted toxicity. These mechanisms are an obstacle for maintaining a sustainable effect for many chronic medications. Pathways that adapt to the burden induced by chronic drugs, whether or not related to the underlying disease, can lead to a partial or complete loss of effect. Variability characterizes many biological systems and manifests itself as large intra- and inter-individual differences in the response to drugs. Circadian rhythm-based chronotherapy is further associated with variability in responses noted among patients. This paper reviews current knowledge regarding the loss of effect of chronic medications and the range of variabilities that have been described in responses and loss of responses. Establishment of a personalized platform for overcoming these prohibitive mechanisms is presented as a model for ensuring long-term sustained medication effects. This novel platform implements personalized variability signatures and individualized circadian rhythms for preventing and opposing the prohibitive effect of the compensatory mechanisms induced by chronic drug administration.

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Circadian Rhythm of Cardiovascular Disease: The Potential of Chronotherapy With Aspirin

Cited by 37 publications

References 71 publications

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects

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