Circadian Rhythm of Gastric Acid Secretion in Man

Moore, John G.; Englert, Edwin

doi:10.1038/2261261a0

Cited by 217 publications

(68 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a recent review article, Hoogerwerf (40) concluded that "it remains to be determined whether sleep-related motility changes are a direct consequence of sleep-induced changes in autonomic neural input or if changes in colonic motility are under circadian clock control." The work of Moore et al (41)(42)(43) demonstrated that gastric acid secretion profile was high in the evening and low in the morning. Duane et al (44) showed that bile acid synthesis has a circadian rhythm with increased synthesis during daytime.…”

Section: Cancermentioning

confidence: 99%

Gastrointestinal disorders among shift workers

Knutsson¹,

Bøggild²

2010

Scand J Work Environ Health

239

178

View full text Add to dashboard Cite

Section: Cancermentioning

confidence: 99%

Gastrointestinal disorders among shift workers

Knutsson¹,

Bøggild²

2010

Scand J Work Environ Health

239

178

View full text Add to dashboard Cite

“…Gastric acid secretion and pH, motility, gastric emptying time, and gastrointestinal blood flow vary according to the time of day. 19,20) Such changes may contribute to the dosing time-dependent difference of drug absorption. For example, circadian changes in pH may induce circadian modifications of drug ionization according to its physicochemical properties.…”

Section: Influence Of Biological Rhythms On Phar-macodynamics and Phamentioning

confidence: 99%

Chronopharmaceutics: Pharmaceutics Focused on Biological Rhythm

Ohdo

2010

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

INTRODUCTIONThe mammalian circadian pacemaker resides in the suprachiasmatic nuclei (SCN) and influences a multitude of biological processes, including the sleep-wake rhythm.1) The circadian clock acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 h cycles. Clock genes are identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior.2)The individualization of pharmacotherapy has been performed mainly by monitoring drug concentrations. However, a pharmacogenetic approach such as genetic diagnosis has become a very attractive field due to the rapid progress of molecular biology.3) Consequently, dosage adjustment has been based on the interindividual differences in drug pharmacokinetics. However, intraindividual variability as well as interindividual variability should be considered in order to achieve further improvement of rational pharmacotherapy. This is because many drugs vary in potency and/or toxicity associated with the rhythmicity of biochemical, physiological and behavioral processes. [4][5][6][7][8] Theoretically, it has been argued that drug administration at certain times of the day should improve the outcome of pharmacotherapy.Biological rhythms not only impact the function of physiology, but also the pathophysiology of diseases. [4][5][6][7][8] Chronopharmacology is the investigative science that elucidates the biological rhythm dependencies of medications. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 h rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also pharmacokinetics of medications. The knowledge of 24 h rhythm in the risk of disease plus evidence of 24 h rhythm dependencies of drug pharmacokinetics, effects, and safety constitutes the rationale for pharmacotherapy (chronotherapy). Chronotherapy is especially relevant in the following cases. [4][5][6][7][8] The risk and/or intensity of the symptoms of disease vary predictably over time as exemplified by allergic rhinitis, arthritis, asthma, myocardial infarction, congestive heart failure, stroke, and peptic ulcer disease. From the viewpoint of pharmaceutics, the application of biological rhythm to pharmacotherapy may be accomplished by the appropriate timing of conventionally formulated tablets and capsules, and special drug delivery systems to synchronize drug concentrations to rhythms in disease activity. 7) Pharmaceutical companies have focused on the investigation of underlying mechanisms as well as the conduct of multicenter clinical studies involving numerous patients with the purpose of devising chronotherapeutic interventions with a variety of medications. New technology for delivering medications precisely in a time-modulated fashion by bedside or ambulatory pumps is being developed to manage human dis...

show abstract

“…Many of the functions of the gastrointestinal tract are subject to circadian rhythms: gastric acid secretion is highest at night [21,22], while gastric and small bowel motility and gastric emptying are all slower at night. During night time, when gastric motility and emptying are slower, drug disintegration, dissolution, and absorption may be slower [23].…”

Section: Duodenal Ulcermentioning

confidence: 99%

Recent trends in pulsatile drug delivery systems - A review.

Sharma¹,

Srikanth²,

Uhumwangho³

et al. 2010

Int j Drug delivery

View full text Add to dashboard Cite

The purpose of writing this review on pulsatile drug delivery systems (PDDS) is to compile the recent literatures with special focus on the different types and approaches involved in the development of the formulation. PDDS are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system, stimuli induced PDDS in which release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. This review also summarizes some current PDDS already available in the market. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

show abstract

Circadian Rhythm of Gastric Acid Secretion in Man

Cited by 217 publications

References 7 publications

Gastrointestinal disorders among shift workers

Gastrointestinal disorders among shift workers

Chronopharmaceutics: Pharmaceutics Focused on Biological Rhythm

Recent trends in pulsatile drug delivery systems - A review.

Contact Info

Product

Resources

About