Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancies

Miyamoto, Saku; Shimokawa, H; Sumioki, Hisao

doi:10.1016/0020-7292(88)90160-9

Cited by 30 publications

(38 citation statements)

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“…The loss of circadian BP rhythmicity and a paradoxical increase in BP during sleep has been reported in PIH patients until a complete reversal of the circadian pattern [15,19,[36][37][38][39]. In this study, most of the women had an acceptable BP profile.…”

Section: Discussionmentioning

confidence: 57%

“…An increase in the circadian BP amplitude had been observed to occur before an increase in the MESOR of BP in the stroke-prone spontaneouslyhypertensive Okamoto rat (handled for measurements) [40], perhaps reflecting an increased vascular reactivity. An increase in vascular responsiveness has been described in hypertensive pregnant patients [19], and it is possible that the circadian amplitude of systolic BP could become a useful marker in pregnancy, but the small sample size of this study does not allow us to draw definitive conclusions.…”

Section: Discussionmentioning

confidence: 83%

“…This rhythmicity is also present throughout pregnancy [15][16][17]. An altered circadian pattern has been reported in pregnancy-induced hypertension [18] and in severe preeclamsia, where a complete reversal of the BP variation has been reported [19,20]. Single BP measurements are then only a poor indicator of the complex adaptation of the maternal circulation, while BP variability needs to be considered [7][8][9][10][11]13,[21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Circadian rhythm of maternal blood pressure and fetal growth

Maggioni¹,

Cornelissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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This study aimed at examining any relation between the circadian variation in blood pressure (BP) in human pregnancy and fetal growth. A prospective study included 52 pregnant women monitored during the third trimester of pregnancy. There were 33 uncomplicated pregnancies with normal fetal growth (Group 1) and 19 pregnancies complicated by intrauterine growth retardation (IUGR), confirmed at birth (Group 2). Ten women (five in each group) had pregnancy-induced hypertension. All women were hospitalized and followed a similar daily routine. BP was recorded with an automatic wearable device. Measurements were obtained every 20 min for 24 ± 1 h. BP profiles were analyzed by conventional statistical methods and by cosinor, involving the least squares fit of cosine curves with an anticipated period (24 h) to the data. BP parameters, fetal outcome, demographic and obstetric characteristics were compared between the two groups. Logistic regression and multivariate analyses were used to assess factors putatively associated with fetal outcome. The circadian amplitude of diastolic BP was found to be larger in normotensive women with IUGR. As gauged by odds ratios (OR), the circadian amplitude of diastolic BP (OR = 1.7, 95% CI: 1.1-2.8; P = 0.03) and hematocrit (OR = 1.4, 95% CI: 1.0-1.9; P = 0.04) were the only variables positively and independently associated with IUGR. In the presence of maternal hypertension, the circadian amplitude of systolic BP was negatively associated with IUGR (OR = 0.7, 95% CI: 0.5-1.0; P = 0.03). A larger circadian variation in diastolic BP, rather than a difference in the mean value of systolic or diastolic BP, was found to be statistically significantly associated with IUGR. This study adds another condition in which the circadian BP amplitude constitutes a harbinger of elevated risk, apart from an association with a shortened lifespan in the absence or presence of malignant hypertension and with an increased risk of stroke and nephropathy reported earlier.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Circadian rhythm of maternal blood pressure and fetal growth

Maggioni¹,

Cornelissen²,

Otsuka³

et al. 2005

Biomedicine & Pharmacotherapy

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“…Some authors demonstrated an elevation of plasma ANF levels during normal pregnancy and much higher levels in patients suffering from EPH-gestosis [2,7,8,10]. Higher ANF levels in normal pregnancy were thought to be a consequence of the increased blood volume.…”

Section: Discussionmentioning

confidence: 99%

Renal and Hormonal Reactions During Water Immersion in Healthy Pregnant Women and Patients with EPH-Gestosis

Schnizer¹,

Mesrogli

Gerbes³

et al. 1989

Endocrinology of the Heart

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“…For these reasons its possible pathophysiologic role has been studied in preeclapmsia (Thomsen et al 1987;Fivet et al 1988;Frohlicha 1988;Hirai et al 1988;Miyamoto et al 1988;Bond et al 1989;Hatji et al 1989;Dessi-Fulgheri et al 1990;McCane et al 1990). The renin-angiotensin system and the balance of prostacyclin (PGI2) and thromboxane A2 (TXA2) is known to play an important role in preeclampsia (Bond et al 1989;Furuhashi et al 1990).…”

mentioning

confidence: 99%

Maternal and Fetal Atrial Natriuretic Peptide Levels, Maternal Plasma Renin Activity, Angiotensin II, Prostacyclin and Thromboxane A2 Levels in Normal and Preeclamptic Pregnancies.

Furuhashi

Tsujiei²,

Kimura³

et al. 1991

Tohoku J. Exp. Med.

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To clarify the possible role of elevated atrial natriuretic peptide (ANP) in the pathophysiology of preeclapmsia, we measured ANP, renin activity (PRA), angiotensin II (Ang II), TXB2 (a stable metabolite of TXA2) and 6-keto-PGFIa (a stable end product of PGI2) concentrations in the plasma of 19 normal pregnant women and 35 severe preeclamptic patients at term. Plasma ANP levels in the preeclamptic patients (n = 35, 71.5 + 3.8 pg/ml, mean+ s.E.) and also umbilical plasma ANP (n = 35, 83.0± 4.2 pg/ml) were significantly (p <0.01) higher than those of normal pregnant women plasma (n=19, 58.7± 3.7 pg/ml) and umbilical plasma (n =19, 47.6±4.7 pg/ml ). There was a significant (p <0.01) positive correlation between maternal ANP levels and fetal ANP levels (n = 54, r = 0.44). Plasma PRA and 6-keto-PGFIa levels in preeclampsia were significantly (p <0.05) lower than those of normal pregnancy. The ratio of 6-keto-PGFIa/TXB2 in preeclampsia was significantly (p <0.01) lower than that of normal pregnancy as we reported previously. There was no significant correlation between plasma ANP level and plasma PRA, Ang II, plasma TXB2 and 6-keto-PGFI a concentrations. Moreover there was no significant correlation between plasma ANP level and the severity of preeclampsia. These data suggest the possibility of a transplacental crossing of ANP secreted by feto-placental unit, which might be, at least in part, responsible for the high ANP levels observed in preeclampsia. The ANP in preeclampsia is not related directly to hypertension, but it may play a substantial role in the regulation or normalization of blood volume and vascular reactivity.atrial natriuretic peptide ; plasma renin activity ; preeclampsia ; Prostacyclin ; thromboxane A2 Atrial natriuretic peptide (ANP) is a peptide, synthesized and released from

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Circadian rhythm of plasma atrial natriuretic peptide, aldosterone, and blood pressure during the third trimester in normal and preeclamptic pregnancies

Cited by 30 publications

References 0 publications

Circadian rhythm of maternal blood pressure and fetal growth

Circadian rhythm of maternal blood pressure and fetal growth

Renal and Hormonal Reactions During Water Immersion in Healthy Pregnant Women and Patients with EPH-Gestosis

Maternal and Fetal Atrial Natriuretic Peptide Levels, Maternal Plasma Renin Activity, Angiotensin II, Prostacyclin and Thromboxane A2 Levels in Normal and Preeclamptic Pregnancies.

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